BIOCHEMICAL MARKERS OF BONE TURNOVER FOR THE CLINICAL ASSESSMENT OF BONE METABOLISM

The Biosynthesis of Collagen and Its Disorders

1979 • 1,067 citations

Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function

1982 • 992 citations

Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

1976 • 782 citations

A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross-linked N-telopeptides in urine

1992 • 667 citations

Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography

1984 • 666 citations

Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation

1993 • 644 citations

The Biosynthesis of Collagen and Its Disorders

1979 • 573 citations

Heritable Diseases of Collagen

1984 • 572 citations

Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen

1990 • 531 citations

Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.

1981 • 495 citations

Biosynthesis of Procollagen

1978 • 452 citations

Serum markers of type I collagen formation and degradation in metabolic bone disease: Correlation with bone histomorphometry

1993 • 450 citations

Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma.

1980 • 433 citations

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

1989 • 409 citations

Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues

1988 • 404 citations

Effect of Menopause and Hormone Replacement Therapy on the Urinary Excretion of Pyridinium Cross-Links

1991 • 366 citations

Alkaline phosphatase isoenzymes.

1982 • 342 citations

Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women

1987 • 266 citations

Osteocalcin in Human Serum: A Circadian Rhythm*

1985 • 263 citations

Concurrent Assays of Circulating Bone Gla-Protein and Bone Alkaline Phosphatase: Effects of Sex, Age, and Metabolic Bone Disease*

1988 • 253 citations

Immunoassay for urinary pyridinoline: The new marker of bone resorption

1993 • 245 citations

Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases

1991 • 202 citations

Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption.

1987 • 198 citations

Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women.

1992 • 197 citations

Plasma BGP: an indicator of spontaneous bone loss and of the effect of oestrogen treatment in postmenopausal women

1988 • 178 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women.

1993 • 171 citations

Estimation of bone turnover evaluated by 47Ca-kinetics. Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, and urinary hydroxyproline excretion.

1985 • 166 citations

An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.

1993 • 164 citations

Immunoassay of pyridinoline crosslink excretion in normal adults and in paget's disease

1993 • 158 citations

Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful prognostic indicator in multiple myeloma

1992 • 154 citations

Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis

1984 • 153 citations

Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women

1992 • 151 citations

Urinary hydroxypyridinium cross-links of collagen in primary hyperparathyroidism.

1992 • 143 citations

Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism

1970 • 136 citations

Urinary pyridinium cross-links as markers of bone resorption in tumor-associated hypercalcemia.

1992 • 134 citations

Procollagen: biological scission of amino and carboxyl extension peptides.

1975 • 132 citations

Changes in markers of bone formation and resorption in a bed rest model of weightlessness

1993 • 131 citations

New biomarkers of bone resorption.

1992 • 129 citations

Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro

1985 • 127 citations

Bone remodeling and calcium metabolism: A correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's disease

1977 • 121 citations

The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase

1990 • 120 citations

Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin.

1981 • 109 citations

The Isolation of Identical Hydroxylysyl Glycosides from Hydrolysates of Soluble Collagen and from Human Urine

1967 • 99 citations

Bone-Resorption Markers Galactosyl Hydroxylysine, Pyridinium Crosslinks, and Hydroxyproline Compared

1992 • 96 citations

Multiple Osteocalcin Fragments in Human Urine and Serum as Detected by a Midmolecule Osteocalcin Radioimmunoassay*

1990 • 88 citations

The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects.

1988 • 88 citations

Differences in basal and postexercise osteocalcin levels in athletic and nonathletic humans

1988 • 86 citations

Measurement of the fasting urinary hydroxyproline: creatinine ratio in normal adults and its variation with age and sex.

1982 • 84 citations

Collagen biosynthesis. Characterization of subcellular fractions from embryonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases

1974 • 73 citations

Automated differential isoenzyme analysis. II. The fractionation of serum alkaline phosphatases into "liver", "intestinal" and "other" components.

1971 • 68 citations

Development of a new radioimmunoassay for human osteocalcin: Evidence for a midmolecule epitope

1988 • 65 citations

The Aminopropeptide of Collagen

1981 • 61 citations

Serum Osteocalcin Levels and Bone Alkaline Phosphatase Isoenzyme after Oophorectomy and in Primary Hyperparathyroidism*

1987 • 60 citations

Urinary pyridinium cross-links as markers of bone resorption in tumor- associated hypercalcemia

1992 • 60 citations

Assessment of bone formation by biochemical markers in metabolic bone disease: Separation between osteoblastic activity at the cell and tissue level

1992 • 57 citations

1,25-Dihydroxyvitamin D3 stimulates both alkaline phosphatase gene transcription and mRNA stability in human bone cells

1991 • 56 citations

Age and sex dependency of the biochemical indices of bone remodelling

1985 • 56 citations

Turnover rate of skeletal alkaline phosphatase in humans.

1982 • 52 citations

Immunological and biochemical evidence for identity of tartrate-resistant isoenzymes of acid phosphatases from human serum and tissues.

1980 • 48 citations

Collagen and Disorders of Bone

1980 • 46 citations

Immunological and biochemical evidence for identity of tartrate-resistant isoenzymes of acid phosphatases from human serum and tissues.

1980 • 42 citations

Procollagen Type I C-Terminal Extension Peptide in Predialysis Chronic Renal Failure

1992 • 40 citations

Synthetic peptide-based immunoassay for amino-terminal propeptide of type I procollagen: application for evaluation of bone formation

1993 • 40 citations

Determination of galactosyl hydroxylysine in urine as a means for the identification of osteoporotic women.

1988 • 39 citations

Biochemical markers of bone turnover in paget's disease

1981 • 38 citations

Enzyme immunoassay for tartrate-resistant acid phosphatase.

1982 • 33 citations

Plasma bone Gla protein concentrations in healthy adults. Dependence on sex, age, and glomerular filtration

1987 • 33 citations

Serum bone Gla protein variations during estrogen and calcium prophylaxis of postmenopausal women

1984 • 31 citations

Relationship between the location of osteoblastic alkaline phosphatase activity and bone formation in human iliac crest bone

1992 • 31 citations

Plasma bone Gla protein concentrations in healthy adults. Dependence on sex, age, and glomerular filtration

1987 • 28 citations

Fine structural localization of alkaline phosphomonoesterase in the fracture callus of the rat.

1971 • 27 citations

Determination of galactosyl hydroxylysine in urine as a means for the identification of osteoporotic women

1988 • 16 citations

Quantitation of human intestinal and liver/bone alkaline phosphatase in serum by rocket electroimmunoassay

1984 • 15 citations

Increase in pyridinoline cross-linking of mouse bone collagen induced by estrogen

1982 • 9 citations

Improved radiochemical method for measuring ferrochelatase activity.

1980 • 8 citations

Further evidence of elevated bone resorption in Ullrich‐Turner syndrome by measuring urinary galactosyl‐hydroxylysine

1992 • 3 citations

The Laboratory Evaluation of Osteopenia

1984 • 3 citations

13. Validation of collagen crosslinks as markers of bone resorption: comparison with radioisotopic method

1991 • 1 citations