THE PATHOLOGY OF EXPERIMENTAL LIVER CELL CANCER

Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies

1954 • 2,755 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY

1969 • 940 citations

Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors

1971 • 892 citations

The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine

1956 • 877 citations

Handbuch der allgemeinen pathologie

1973 • 816 citations

Xeroderma Pigmentosum

1974 • 755 citations

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review.

1969 • 510 citations

Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

1971 • 412 citations

The toxic actions of pyrrolizidine (senecio) alkaloids.

1970 • 380 citations

Induction of Liver Growth by Xenobiotic Compounds and Other Stimuli

1974 • 352 citations

The Physiopathology of Cancer

1959 • 312 citations

Ethionine Carcinogenesis

1963 • 296 citations

Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1975 • 257 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Neoplasia: a disease of cell differentiation.

1968 • 241 citations

γ-Glutamyl Transpeptidase in Transplantable, Chemically Induced Rat Hepatomas and “Spontaneous” Mouse Hepatomas<xref ref-type="fn" rid="FN2">2</xref>

1972 • 238 citations

Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.

1972 • 227 citations

Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.

1971 • 221 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

CELL SIZE, NUCLEAR CONTENT, AND THE DEVELOPMENT OF POLYPLOIDY IN THE MAMMALIAN LIVER

1967 • 197 citations

Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1973 • 193 citations

Changes in the Fine Structure of Rat Liver Cells Brought about by Dimethylnitrosamine

1960 • 193 citations

The action of aflatoxin B1 on the rat liver

1967 • 187 citations

Cancer, Differentiation and Embryonic Antigens: Some Central Problems

1974 • 183 citations

METABOLIC REGULATORY CIRCUITS AND CARCINOGENESIS.

1963 • 172 citations

Progressive microscopic alterations in the livers of rats fed the hepatic carcinogens 3'-methyl-4-dimethylaminoazobenzene and 4'-fluoro-4-dimethylaminoazobenzene.

1952 • 168 citations

Experimentelle Erzeugung des Lebercarcinoms durch Fütterung mit o-Amidoazotoluol

1935 • 165 citations

THE PATHOGENESIS OF TUMORS OF THE LIVER PRODUCED BY BUTTER YELLOW

1944 • 158 citations

Hepatocyte proliferation and alpha 1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats.

1974 • 157 citations

Carcinogenesis--cellular evolution as a unifying thread: Presidential address.

1973 • 155 citations

CARCINOGENESIS: A BROAD CRITIQUE

1968 • 152 citations

A comparison of ultrastructural changes in rat liver due to chemical carcinogens.

1968 • 151 citations

Alcoholic Liver Pathology.

1975 • 144 citations

Activation by Chemical Carcinogens of γ-Glutamyl Transpeptidase in Rat and Mouse Liver 2

1973 • 142 citations

Development of Preneoplastic and Neoplastic Lesions of the Liver in Male Rats Given 0.025 Percent <italic>N</italic>-2-Fluorenyldiacetamide<xref ref-type="fn" rid="FN2">2</xref>

1965 • 128 citations

Hepatic pathology in rats on low dietary levels of dimethylnitrosamine.

1967 • 127 citations

Quantitative Study on Foci of Altered Liver Cells Induced in the Rat by a Single Dose of Diethylnitrosamine and Partial Hepatectomy<xref ref-type="fn" rid="FN1">2</xref>

1972 • 125 citations

Chromosomes of "minimal deviation" hepatomas and some other transplantable rat tumors.

1967 • 121 citations

Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell populations in vivo and in vitro.

1972 • 111 citations

The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.

1975 • 108 citations

Fine Structure of Transplantable Hepatomas of the Rat2

1965 • 102 citations

Sequential morphologic changes in aflatoxin B carcinogenesis in the rat.

1968 • 101 citations

Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: Their contribution to hepatocarcinogenesis in the rat

1975 • 99 citations

Early appearance of embryonic -globulin in rat serum during carcinogenesis with 4-dimethylaminoazobenzene.

1971 • 98 citations

Enzymhistochemische und autoradiographische Untersuchungen w�hrend der Cancerisierung der Rattenleber mit Di�thylnitrosamin

1968 • 98 citations

Isozyme studies on adult, regenerating, precancerous and developing liver in relation to findings in hepatomas

1972 • 96 citations

The predictive value of mouse liver tumour induction in carcinogenicity testing—a literature survey

1973 • 95 citations

The histology of the rat's liver during the course of carcinogenesis by butter‐yellow (p‐dimethylaminoazobenzene)

1940 • 93 citations

Notizen: Histochemische Untersuchungen über die Glucose-6-Phosphatase in der Rattenleber während der Kanzerisierung durch Nitrosamine

1964 • 92 citations

Absence of Stainable Iron From Preneoplastic and Neoplastic Lesions in Rat Liver With 8-Hydroxyquinoline-Induced Siderosis

1972 • 84 citations

Pathologic Changes, With Special Reference to Pigmentation and Classification of Hepatic Tumors in Rats Fed <italic>p</italic>-Dimethylaminoazobenzene (Butter Yellow)<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1941 • 83 citations

Probable clonal genesis of cellular islands induced in rat liver by diethylnitrosamine

1971 • 81 citations

Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach zeitlich begrenzter Verabfolgung von Di�thylnitrosamin

1969 • 80 citations

CELLULAR POPULATIONS AND MITOTIC ACTIVITY IN RAT LIVER PARENCHYMA DURING AZO DYE CARCINOGENESIS.

1964 • 80 citations

The carcinogenic effect of aramite in rats.A study of hepatic nodules

1960 • 77 citations

Histopathology of Carcinogenesis and Tumors of the Liver in Rats<xref ref-type="fn" rid="fn1">1</xref>

1955 • 76 citations

Tissue Regeneration and Tumour Development

1959 • 73 citations

Influence of Certain Polycyclic Hydrocarbons on the Growth of the Jensen Rat Sarcoma

1935 • 70 citations

A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylaminoazobenzene.

1973 • 68 citations

Some Growth, Morphological, and Biochemical Characteristics of Hepatoma 5123 and Other New Transplantable Hepatomas

2015 • 67 citations

THE EVOLUTION OF HUMAN CIRRHOSIS DEDUCED FROM OBSERVATIONS IN EXPERIMENTAL ANIMALS

1967 • 64 citations

[The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis].

1969 • 64 citations

α‐fetoprotein and hepatocarcinogenesis in rats fed 3′‐methyl‐4‐(dimethylamino)azobenzene or n‐2‐fluorenylacetamide

1972 • 63 citations

The Pathology of Transcription and Translation.

1974 • 61 citations

Effects of the pyrrolizidine alkaloid, lasiocarpine N‐oxide, on nuclear and cell division in the liver of rats

1965 • 61 citations

Die Beeinflussung der Nitrosamincarcinogenese durch Phenobarbital und Halogenkohlenwasserstoffe

1969 • 60 citations

Effects of cirrhosis and other liver insults on induction of liver tumors by aflatoxin in rats.

1966 • 58 citations

A Possible Mechanism for the Erythrocytosis Associated with Hepatocellular Carcinoma in Man

1970 • 56 citations

Aflatoxin B1 carcinogenesis in lipotrope-deficient rats.

1969 • 55 citations

Sensitivity of Normal and Neoplastic Cells to the Damaging Action of Carcinogenic Substances: A Review

1963 • 55 citations

Early elevation of alpha 1-fetoprotein in N-2-fluorenylacetamide hepatocarcinogenesis.

1974 • 54 citations

Liver Regeneration After Partial Hepatectomy in Carbon Tetrachloride-Induced Cirrhosis in the Rat

1961 • 54 citations

Localization of Rat Liver α-Foetoprotein by Cell Affinity Labelling with Tritiated Oestrogens

1973 • 52 citations

Tumor-Associated Transplantation Antigens of Myelomas Induced in BALB/c Mice2

1972 • 52 citations

Inhibition of Incorporation of Thymidine into Deoxyribonucleic Acid by Amino Acid Antagonists in Vivo

1960 • 51 citations

Toxic liver necrosis.

1966 • 51 citations

Characterization of primary hepatocellular carcinomas and initial transplant generations.

1973 • 51 citations

THE FINE STRUCTURE OF PROLIFERATING CELLS IN PRENEOPLASTIC RAT LIVERS DURING AZO-DYE CARCINOGENESIS

1969 • 49 citations

The value of the mouse in carcinogenicity testing.

1972 • 49 citations

Liver Necrosis and the Induction of Carbon Tetrachloride Hepatomas in Strain a Mice

1946 • 48 citations

Systematic oscillations in metabolic activity in rat liver and hepatomas. Survey of normal diploid and other hepatoma lines.

1969 • 48 citations

Chromosomes of Tumor Cells. II. Effect of Various Liver Carcinogens on Mitosis of Hepatic Cells

1961 • 47 citations

Regenerative hyperplasia of the cirrhotic liver following partial hepatectomy

1958 • 47 citations

Pyrrolizidine alkaloids

1979 • 46 citations

A New Common Marker for Premalignant and Malignant Hepatocytes Induced in the Rat by Chemical Carcinogens2

1975 • 46 citations

The reversibility of inhibition of RNA and DNA synthesis induced by aflatoxin in rat liver. A tentative explanation for carcinogenic mechanism

1970 • 46 citations

Action de l'aflatoxine sur le métabolisme du DNA au cours de l'hypertrophie compensatrice du foie après hepatectomie partielle

1966 • 44 citations

The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding.

1975 • 44 citations

Localization of alpha-fetoprotein by immunofluorescence in hyperplastic nodules during hepatocarcinogenesis induced by 2-acetylaminofluorene.

1974 • 44 citations

Chemical Carcinogenesis: Persistence of Bound Forms of 2-Fluorenylacetamide

1968 • 42 citations

Polyploid cell reproduction in normal adult rat liver

1967 • 42 citations

Chromosome Patterns in Rat Hepatocytes During <italic>N</italic>-2-Fluorenylacetamide Carcinogenesis<xref ref-type="fn" rid="FN2">2</xref>

1971 • 42 citations

The cellular analysis of liver carcinogenesis: ultrastructural alterations within hyperplastic liver nodules induced by 2-fluorenylacetamide.

1967 • 41 citations

Cellular Analysis of Liver Carcinogenesis. III. Comparison of the Ultrastructure of Hyperplastic Liver Nodules and Hepatocellular Carcinomas Induced in Rat Liver by 2-Fluorenylacetamide<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 41 citations

Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis.

1970 • 39 citations

The effects of aflatoxin B1 and dimethylsulfoxide on thymidine-3H uptake and mitosis in rat liver.

1967 • 37 citations

Changes in the fine structure of rat hepatocytes during the early phases of chronic 2-acetylaminofluorene intoxication

1970 • 36 citations

Morphologic and Biologic Correlation of Lesions Obtained in Hepatic Carcinogenesis in A × C Rats Given 0.025 Percent <italic>N</italic>-2-Fluorenyl-diacetamide<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1963 • 35 citations

A study of two types of ferritin from rat hepatomas.

1970 • 34 citations

Specific stages of cellular response to homeostatic control during diethylnitrosamine-induced liver carcinogenesis

1970 • 34 citations

Combined enzyme histochemical and radioautographic studies on areas of hyperplasia in the liver of rats fed N-2-fluorenylacetamide.

1973 • 34 citations

ERYTHROCYTOSIS ASSOCIATED WITH CARCINOMA OF THE LIVER (WITH ERYTHROPOIETIN ASSAY OF TUMOR EXTRACT)

1966 • 33 citations

QUANTITATIVE ASSESSMENT OF THE PERSISTENT ANTIMITOTIC EFFECT OF CERTAIN HEPATOTOXIC PYRROLIZIDINE ALKALOIDS ON RAT LIVER

1968 • 32 citations

Role of Injury and Hyperplasia in the Induction of Hepatocellular Carcinoma

1961 • 32 citations

Some factors regulating the structural integrity of the intrahepatic bile ducts with special reference to primary carcinoma of the liver and vitamin A

1954 • 31 citations

The effect of L-asparaginase on mitotic activity during N-2-fluorenylacetamide hepatocarcinogenesis: subpopulations of nodular cells.

1971 • 30 citations

Control processes in neoplasia

1974 • 30 citations

Variations in the Cell Cycle During Azo Dye Hepatocarcinogenesis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1968 • 30 citations

Characterization and subunit analysis of ferritin isolated from normal and malignant human liver.

1975 • 30 citations

DNA synthesis and neoplastic transformation in rat liver parenchyma.

1966 • 30 citations

Isozyme patterns of pyruvate kinase in various primary liver tumors induced during the process of hepatocarcinogenesis.

1974 • 29 citations

An enzymic study on the cellular origin of the DUNNING and the NOVIKOFF hepatomas in the rat

1960 • 29 citations

DNA binding and inhibition of DNA synthesis after 7,12-dimethylbenz(a)anthracene administered during the early prereplicative phase in regenerating rat liver.

1972 • 29 citations

Responsiveness of glutamine-metabolizing enzymes in Morris hepatomas to metabolic modulations.

1970 • 29 citations

REGULATION OF MITOTIC RATE IN MAMMALIAN ORGANISMS

1960 • 28 citations

Chromosomes of "minimal deviation" hepatomas: a further report on diploid tumors.

1969 • 27 citations

Subcellular localization of surface adenosine triphosphatase activity in preneoplastic liver parenchyma.

1972 • 27 citations

Permanent changes in the fine structure of rat hepatocytes following prolonged treatment with 2-acetylaminofluorene

1968 • 27 citations

The effects of 7,12-dimethylbenz(alpha)anthracene on the synthesis of nucleic acids in rapidly dividing hepatic cells in rats.

1970 • 27 citations

The interaction of [3H]ethyl carbamate with nucleic acids of regenerating mouse liver

1972 • 26 citations

Distinctive Cells Similar to Fetal Hepatocytes Associated With Liver Carcinogenesis by Diethylnitrosamine. Electron Microscopic Study 2 3

1973 • 26 citations

Azo-Dye Carcinogenesis: Ribonucleotides and Ribonucleases

1963 • 25 citations

Tumor hypoglycemia: A heterogeneous disorder

1970 • 23 citations

Electron microscopy of cirrhotic nodule Tubularization of the parenchyma by biliary hepatocytes.

1966 • 23 citations

Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide

1970 • 23 citations

A Study of α1-Fetoprotein Levels during Exposure to 3′-Methyl-4-dimethylaminoazobenzene and Its Analogs

1975 • 22 citations

Spectrophotometric analysis of cytochromes in rat liver during carcinogenesis.

1974 • 22 citations

Human Hepatocarcinoma and the Comparative Embryology of the Vertebrate Liver&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;

1955 • 22 citations

The effect of urethan on the incorporation of thymidine-3H into DNA and the activities of some enzymes required for DNA biosynthesis in rat regenerating liver.

1973 • 21 citations

Alteration of hepatocytes by subcarcinogenic exposure to n-2-fluorenylacetamide.

1975 • 20 citations

Lasiocarpine: Factors influencing its toxicity and effects on liver cell division

1971 • 20 citations

Histochemical studies on nuclease activity and neoplastic transformation in rat liver during diethylnitrosamine carcinogenesis.

1973 • 20 citations

Mitotic Blockage at G&lt;sub&gt;2&lt;/sub&gt; After Partial Hepatectomy During 4-Dimethylaminoazobenzene Hepatocarcinogenesis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1965 • 20 citations

Role of Cell Proliferation in Hepatic Carcinogenesis.

1964 • 20 citations

Immunological Defence against Preneoplastic Stages of Diethylnitrosamine Induced Carcinomas in Rat Liver

1969 • 19 citations

Histochemical and Morphologic Differentiation of Induced Tumors of the Liver in Rats

1952 • 19 citations

Megalocytosis and other abnormalities expressed during proliferation in regenerating liver of rats treated with methylazoxymethanol acetate prior to partial hepatectomy.

1975 • 19 citations

Fine structure of nuclei as revealed by electron microscopy

1970 • 18 citations

Absence of an effect of partial hepatectomy on aflatoxin B 1 carcinogenesis.

1971 • 18 citations

Chromosomes of Tumor Cells. III. Unresponsiveness of Precancerous Hepatic Tissues and Hepatomas to a Mitotic Stimulus&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;

1962 • 17 citations

Hepatic megalocytosis in chronic lasiocarpine poisoning. Some functional studies.

1971 • 16 citations

Ultrastructural alterations within hyperplastic liver nodules induced by ethionine.

1971 • 16 citations

Further ultrastructural observations on injury of rat hepatic parenchymal cells induced by aflatoxin B1

1971 • 15 citations

Nucleolar Behavior in Regenerating Liver of Rats Receiving Intra-Abdominal Injections of Azo Dyes and Thioacetamide&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1968 • 15 citations

Production of Cirrhosis and Liver Tumors in Male Rats Using High Dosages of 2-Acetylaminofluorene.

1951 • 15 citations

Altered Karyotypes of Transplantable “Diploid” Tumors2

1973 • 14 citations

The effect of 7,12-dimethylbenz(a)anthracene on the incorporation of thymidine-H3 into deoxyribonucleic acid in normal and regenerating liver

1965 • 14 citations

DNA Measurement on Cell Nucleus of Normal Liver, Adenoma, and Hepatoma in Mice: Histologic Features

1971 • 13 citations

Hepatomas in Mice: Incidence Increased after Gamma Irradiation at Low Dose Rates

1965 • 13 citations

Quantitative Untersuchungen �ber den irreversiblen Verlust zweier Enzymaktivit�ten in der Rattenleber nach Verf�tterung von Di�thylnitrosamin

1974 • 12 citations

[Inhibition of proliferative activity of partially resected liver after administration of diethylnitrosamine].

1970 • 12 citations

Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine

1971 • 12 citations

Effect of DL-Ethionine and S-Ethyl-L-Cysteine on Rat Liver Regeneration

1958 • 12 citations

The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver

1973 • 11 citations

Time course of the effects of AAF on mouse liver nucleic acid synthesis and its modification by inhibitors

1972 • 11 citations

Isolation of Two Lines of Transplantable, Ethionine-Induced Rat Hepatomas of High and Low Catalase Activity From a Primary Tumor

1962 • 11 citations

Studies on the incorporation of thymidine into DNA by rat-liver homogenates in vitro

1960 • 11 citations

FORMATION OF CELL COLONIES IN X-IRRADIATED REGENERATING LIVERS OF RATS

1965 • 11 citations

Glycogen Storage in a Hepatoma: Dephosphophosphorylase Kinase Defect

1968 • 11 citations

Enzymhistochemische Untersuchungen über den Nucleosidphosphat- und Kohlenhydratstoffwechsel während der Cancerisierung der Rattenleber mit Diäthylnitrosamin (DÄNA) durch dosierte orale Zufuhr des Cancerogens

1968 • 10 citations

Studies of Insulin and Growth Hormone Secretion in a Subject with Hepatoma and Hypoglycemia

1971 • 10 citations

Mitotic, Chromosomal, and Nucleolar Alterations Induced by Thioacetamide in Relation to the Mitotic Cycle After Partial Hepatectomv

1971 • 10 citations

Lysosomes of rat liver and dab carcinogenesis

1971 • 9 citations

Hemmung der Proliferationsaktivit�t partiell resezierter Leber durch Di�thylnitrosamin

1970 • 9 citations

The role of mutations in liver tumor induction in mice.

1972 • 8 citations

Cytology of Hepatic Tumors and Proliferating Bile Duct Epithelium in the Rat Induced With &lt;italic&gt;p&lt;/italic&gt;-Dimethylaminoazobenzene

1942 • 8 citations

Changes in microsomal enzyme activities during DAB carcinogenesis

1973 • 7 citations

The Role of Mutations in Liver Tumor Induction in Mice

1972 • 6 citations

Mitotic abnormalities in proliferating hepatocytes induced by thioacetamide at certain periods after partial hepatectomy

1969 • 5 citations

Mitotic responses to partial hepatectomy in preneoplastic rat liver

1970 • 5 citations

Alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis. Aminopyrine demethylase activity and ribosome-membrane interaction

1974 • 3 citations

Differential staining of preneoplastic foci in rat liver parenchyma during azo dye carcinogenesis

1971 • 1 citations