Cancer, Differentiation and Embryonic Antigens: Some Central Problems

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

Anti-Angiogenesis

1972 • 1,167 citations

Studies on Abnormal Hemoglobins

1951 • 987 citations

Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors

1971 • 892 citations

ONCOGENES OF RNA TUMOR VIRUSES AS DETERMINANTS OF CANCER

1969 • 868 citations

MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.

1964 • 773 citations

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

1968 • 742 citations

THE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEM

1969 • 710 citations

Suggestive Evidence That the “Blocking Antibodies” of Tumor-Bearing Individuals May Be Antigen-Antibody Complexes

1971 • 691 citations

Demonstration of cell‐mediated immunity to human neoplasms of various histological types

1971 • 673 citations

PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS

1963 • 601 citations

Immunology of Experimental Tumors

1964 • 487 citations

A MICROASSAY FOR CELL-MEDIATED IMMUNITY

1970 • 486 citations

Demonstration of an Antigen Common to Several Varieties of Neoplasia

1971 • 465 citations

Restoration of Normal Growth by Covering of Agglutinin Sites on Tumour Cell Surface

1970 • 347 citations

A serum alkaline phosphatase isoenzyme of human neoplastic cell origin.

1968 • 333 citations

Tumor Antigens

1966 • 323 citations

Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders

1971 • 302 citations

Immunology and Biochemistry of Regan Isoenzyme of Alkaline Phosphatase in Human Cancer

1968 • 298 citations

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

1972 • 289 citations

Tumor Angiogenesis: Transfilter Diffusion Studies in the Hamster by the Transparent Chamber Technique<xref ref-type="fn" rid="FN2">2</xref>

1968 • 288 citations

SERUM-MEDIATED PROTECTION OF NEOPLASTIC CELLS FROM INHIBITION BY LYMPHOCYTES IMMUNE TO THEIR TUMOR-SPECIFIC ANTIGENS

1969 • 264 citations

Neoplasia: a disease of cell differentiation.

1968 • 241 citations

IMMUNOLOGICAL ASPECTS OF PREMATURE OVARIAN FAILURE ASSOCIATED WITH IDIOPATHIC ADDISON'S DISEASE

1968 • 239 citations

Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.

1972 • 227 citations

Abrogation of Cellular Immunity to Antigenically Foreign Mouse Embryonic Cells by a Serum Factor

1969 • 224 citations

Embryonic and Neoplastic Cell Surfaces: Availability of Receptors for Concanavalin A and Wheat Germ Agglutinin

1971 • 216 citations

Group-Specific Antigen Expression During Embryogenesis of the Genome of the C-Type RNA Tumor Virus: Implications for Ontogenesis and Oncogenesis

1970 • 195 citations

Circulating antibodies against carcinoembryonic antigens of the human digestive system

1967 • 190 citations

The Dynamics of Synthesis and Degradation of Polyamines in Normal and Regenerating Rat Liver and Brain

1970 • 189 citations

Enzyme patterns in fetal, adult and neoplastic rat tissues

1976 • 180 citations

Immunological Factors in Human Sarcomas and Melanomas

1970 • 178 citations

Immunologic Diagnosis and Prognosis of Human Digestive-Tract Cancer: Carcinoembryonic Antigens

1972 • 176 citations

THE MASKING OF ANTIGENS ON TROPHOBLAST AND CANCER CELLS

1967 • 175 citations

Ribonucleic acid synthesis in regenerating and embryonic liver

1967 • 169 citations

Immunofluorescent studies on human spermatozoa. I. The detection of different spermatozoal antibodies and their occurrence in normal and infertile women.

1971 • 139 citations

Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells

1970 • 134 citations

Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.

1972 • 132 citations

Fetal Antigen Capable of Inducing Transplantation Immunity against SV40 Hamster Tumor Cells

1970 • 131 citations

IMMUNOHISTOLOGICAL AND ELUTION STUDIES OF THE HUMAN PLACENTA

1971 • 131 citations

Biochemistry of Differentiation

1968 • 130 citations

A review of isozymes in cancer.

1971 • 128 citations

Ectopic Production of Human Chorionic Somatomammotropin by Nontrophoblastic Cancers¹

1971 • 119 citations

Studies on Abnormal Hemoglobins

1951 • 118 citations

Oncogenicity And Cell Transformation By Papovavirus SV40: The Role Of The Viral Genome

1972 • 116 citations

Antigenic Specificity of Benzo[a]pyrene-Induced Sarcomas2

1964 • 107 citations

Association of embryonic antigens with experimentally induced hepatic lesions in the rat.

1967 • 104 citations

Gene expression in amphibian development

1966 • 102 citations

Tumor Immunity in Hamsters Immunized with Fetal Tissues

1971 • 102 citations

Human Embryonic Hæmoglobins

1964 • 100 citations

Alpha-Fetoprotein in a Patient with Gastric Carcinoma Metastatic to the Liver

1971 • 94 citations

Cross Reacting Antigens and Neoantigens.

1968 • 93 citations

Possible association of embryonal antigen(S) with several primary 3‐methylcholanthrene‐induced murine sarcomas

1970 • 93 citations

Protein Subunits: A Table (Second Edition)

1969 • 92 citations

Demonstration of Carcinoembryonic Antigen in Normal Human Plasma

1972 • 86 citations

Cellular membranes and tumor behavior: a new hypothesis.

1968 • 85 citations

Note on the control of gene expression during development

1971 • 83 citations

Expression of Fetal Antigens in Tumor Cells

1972 • 80 citations

Reaction of Serum from Pregnant Hamsters with Surface of Cells Transformed by SV40

1970 • 79 citations

Ectopic Gonadotropin Production before Clinical Recognition of Bronchogenic Carcinoma

1968 • 78 citations

Porosity of the Mouse Placenta to Maternal Cells

1969 • 77 citations

SYNTHESIS AND ACCUMULATION OF POLY AMINES IN REGENERATING RAT LIVER*

1970 • 77 citations

Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion

1971 • 76 citations

Loss of Gastro-intestinal-specific Antigen in Neoplasia

1962 • 73 citations

Specific Plasma Factors blocking Human Maternal Cell-mediated Immune Reaction to Placental Antigens

1973 • 72 citations

Antibodies to Trophoblasts during the Post-Partum Period

1961 • 70 citations

Sulphoglycoprotein antigens in the human alimentary canal and gastric cancer. An immunohistological study

1968 • 68 citations

Occurrence of Fetal Sulphoglycoprotein Antigen in the Gastric Juice of Patients with Gastric Diseases

1969 • 65 citations

The further characterization of autoantibodies reactive with extra-adrenal steroid-producing cells in patients with adrenal disorders.

1969 • 64 citations

Chorionepithelioma of the stomach

1960 • 64 citations

Membranes and Viruses in Immunopathology

1972 • 59 citations

Reaction of Metallic Copper with Biological Substrates

1971 • 59 citations

A Fetal Antigen Associated with Human Neoplasia

1972 • 58 citations

Genetic origin of tumor antigens.

1968 • 56 citations

Antigenic Study of Unfertilized Mouse Eggs: Cross Reactivity with SV40-Induced Antigens

1970 • 55 citations

Evidence suggesting a relationship between polyoma virus-induced transplantation antigen and normal embryonic antigen.

1968 • 52 citations

Présence D'une Ferroprotéine D'origine Tissulaire, L'α₂H, dans le Sérum des Enfants Porteurs de Tumeurs

1970 • 51 citations

Autogenous immunity to endogenous RNA tumor virus antigens in mice with a low natural incidence of lymphoma.

1972 • 50 citations

Uterus of Rodents as Site for Manifestation of Transplantation Immunity Against Transplantable Tumors<xref ref-type="fn" rid="fn1">2</xref>

1962 • 48 citations

Fertilization, Embryo and Fetal Survival Rates in Rabbits Isoimmunized with Semen, Testis, and Conceptus

1968 • 47 citations

Immunology and Reproduction

2019 • 47 citations

Studies on Specific Transplantation Resistance to Polyoma-Virus-Induced Tumors. III. Transplantation Resistance to Genetically Compatible Polyoma Tumors Induced by Polyoma Tumor Homografts<xref ref-type="fn" rid="FN2">2</xref>

1964 • 45 citations

The time of appearance and distribution of sulphoglycoprotein antigens in the human foetal alimentary canal

1968 • 43 citations

Ectopic Polypeptide Hormone Production by Tumors

1970 • 43 citations

Resistance against isotransplantation of mouse tumors induced by Rous sarcoma virus

1963 • 42 citations

Prevention of Simian Virus 40 Tumors by Hamster Fetal Tissue: Influence of Parity Status of Donor Females on Immunogenicity of Fetal Tissue and on Immune Cell Cytotoxicity

1973 • 42 citations

Foetal Antigens and Cancer

1973 • 41 citations

Localization of -fetoprotein in hepatoma tissues by immunofluorescence.

1972 • 41 citations

Primary chorioncarcinoma of the urinary bladder in a male

1960 • 40 citations

The nature of the cell membrane receptor for the agglutination factor present in the sera of tumor patients and pregnant women.

1965 • 39 citations

Effect of fast-growing transplantable hepatoma on cell proliferation in host tissue of the mouse.

1973 • 38 citations

Cytostatic Antibody and SV40 Tumour Immunity in Hamsters

1971 • 38 citations

COMPATIBILITY AND NONCOMPATIBILITY

1955 • 37 citations

Studies on the Function of the Kurloff Cell

1971 • 37 citations

Isoaccepting transfer RNA's in mammalian differentiated cells and tumor tissues.

1971 • 36 citations

Case 13-1972

1972 • 35 citations

Development in Hamsters of Antibodies against Surface Antigens Present in Cells Transformed by Papovavirus SV40

1968 • 34 citations

Purification of Hodgkin's Disease Tumor-Associated Antigens

1973 • 33 citations

Effect of Previous Injection of Homologous Embryonic Tissue on the Growth of Certain Transplantable Mouse Tumours

1967 • 33 citations

Evidence for Fetal Antigen in Human Sarcoma

1973 • 33 citations

Arrangement of Base Sequences in Deoxyribonucleic Acid 1

1967 • 32 citations

Protection of Adult Mice against Tumor Challenge by Immunization with Irradiated Adult Skin or Embryo Cells

1973 • 32 citations

Failure to induce Transplantation Resistance against Polyoma Tumour Cells with Syngeneic Embryonic Tissues

1968 • 32 citations

Effects of Antitumour Immunity on Pregnancy in the Mouse

1973 • 32 citations

Gastric Antigens in Health and Disease. Behaviour in Early Development, Senescence, Metaplasia, and Cancer

1969 • 29 citations

Systemic effects of tumors in force-fed rats. II. Effect on the weight of carcass, adrenals, thymus, liver, and spleen.

1953 • 28 citations

The Agglutination of Tumour Cells In Vitro by Sera from Tumour Patients and Pregnant Women

1964 • 28 citations

Antigenic differences among early developmental stages of Rana pipiens

1953 • 27 citations

THE IMMUNOBIOLOGY OF TRANSPLANTATION

1972 • 27 citations

A TUMOUR TISSUE ANALOGUE OF THE IMPLANTING MOUSE EMBRYO*

1963 • 26 citations

Radioimmunoassay of rat 1 -fetoprotein.

1973 • 26 citations

Extragenital choriocarcinoma

1965 • 25 citations

Genetic deletions at specific loci by polycyclic hydrocarbons in relation to carcinogenesis

1970 • 24 citations

A Rapid in Vivo Assay for SV40 Tumor Immunity in Hamsters

1969 • 23 citations

Cancer of the urogenital tract: testicular tumors.

1970 • 22 citations

Chromosome coiling: Abnormalities induced by polyamines

1960 • 22 citations

Sperm Antibodies as a Cause of Infertility

1971 • 22 citations

BIOLOGICAL ASPECTS OF CANCER

1958 • 21 citations

Raised Foetal Haemoglobin in Childhood Leukaemia

1969 • 21 citations

Cancer of the Urogenital Tract: Testicular Tumors

1970 • 20 citations

Immunological Cross-reactivity of Antigens common to Tumour and Foetal Cells

1972 • 20 citations

Reflexions on Mind

1973 • 19 citations

Analysis of Surface Antigens on Simian Virus 40-Transformed Cells. I. Unique Antigenicity of Simian Virus 40-Transformed Outbred Hamster Kidney Cell Lines2

1973 • 19 citations

Choriocarcinoma of the Thymus

1962 • 19 citations

Naturally occurring antibody to placental protein in human pregnancy

1970 • 18 citations

Placental hormones and graft rejection

1969 • 17 citations

Search for cross-reacting antigenicity between mammary tumor virus-induced mammary tumors and embryonic antigens: effect of immunization on development of spontaneous mammary tumors.

1970 • 17 citations

TUMOUR IMMUNOLOGY AND EVOLUTION OF THE PLACENTA

1970 • 16 citations

Immunchemische Untersuchungen zum Problem der ?pregnancy zone?

1969 • 16 citations

Characterization of Tumor-Specific Transplantation Immunity Reactions in Immunodiffusion Chambers in Vivo

1969 • 14 citations

Immunologic studies of the fetal allograft.

1971 • 14 citations

Localization of Gallium-67 During Embryogenesis

1973 • 11 citations

Diamine oxidase as an index of the fetoplacental unit. Clinical applications.

1968 • 11 citations

A study of the cell surface of tumour, foetal and lymph-node cells by cell electrophoresis after antibody and enzymic treatment

1972 • 10 citations

STUDIES ON ANTIGENIC DIFFERENTIATION IN THE EMBRYONIC DEVELOPMENT OF RANA TEMPORARIA L.I. AGAR PRECIPITATION TESTS.

1964 • 10 citations

Primary Mediastinal Choriocarcinoma

1964 • 9 citations

Phase Specific Surface Autoantigens on Membranes of Fetus and Tumors

1973 • 9 citations

Cross-reaction between benzpyrene-induced tumours in rats and mice.

1963 • 7 citations

Precipitin reactions and developmental arrest by antisera in amphibian embryos

1961 • 7 citations

Transfer from Mother to Offspring of Antifetal Antibody Induced in the Mouse by Multiparity

1968 • 7 citations

Cyclic AMP Levels in the Developing Hamster Foetus: a Correlation with the Phasing of Foetal Antigen in Membrane Maturation

1973 • 6 citations

Clinical Uses of Radionuclides: Critical Comparison With Other Techniques

1973 • 6 citations

A New Approach to Tumour Immunity

1960 • 6 citations

Growth of transplanted tissues derived from normal and overripe frog's eggs

1955 • 6 citations

Die Immunogenit�t der menschlichen Placenta

1971 • 4 citations

The function of the Kurloff cell and its possible relation to the immunological status of the guinea-pig placenta.

1970 • 4 citations

[Demonstration of antibodies against placental tissue in normal pregnancy and late toxicoses].

1970 • 3 citations

STUDIES ON ANTIGENIC DIFFERENTIATION IN THE EMBRYONIC DEVELOPMENT OF RANA TEMPORARIA L. II. RING TEST.

1964 • 3 citations

Protein Synthesis in Frog Embryos and Frog Liver Preparations, and Its Inhibition by Embryo Components

1968 • 2 citations

Agglutinierende Leukocyten- und cytotoxische Isoantik�rper in der Schwangerschaft

1971 • 1 citations