Chemoprevention of Head and Neck Cancers

The Hallmarks of Cancer

2000 • 27,569 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Nomenclature and classification of potentially malignant disorders of the oral mucosa

2007 • 1,605 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Genetic progression model for head and neck cancer: implications for field cancerization.

1996 • 1,340 citations

Oral leukoplakia and malignant transformation. A follow-up study of 257 patients

1984 • 1,040 citations

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

1976 • 993 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

P<scp>rognosis of</scp> O<scp>ral</scp> P<scp>re-malignant</scp> L<scp>esions:</scp> S<scp>ignificance of</scp> C<scp>linical,</scp> H<scp>istopathological, and</scp> M<scp>olecular</scp> B<scp>iological</scp> C<scp>haracteristics</scp>

2003 • 546 citations

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

2000 • 529 citations

Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

1996 • 521 citations

Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10‐year follow‐up study of Indian villagers

1980 • 456 citations

Long-term treatment outcome of oral premalignant lesions

2005 • 433 citations

Predicting cancer development in oral leukoplakia: ten years of translational research.

2000 • 426 citations

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.

2000 • 420 citations

Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis

1993 • 402 citations

EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer

2000 • 385 citations

Second malignancies in patients who have head and neck cancer: Incidence, effect on survival and implications based on the RTOG experience

1989 • 381 citations

Pooled estimate of world leukoplakia prevalence: a systematic review

2003 • 378 citations

Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development.

2002 • 375 citations

Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands

1998 • 362 citations

Proliferative verrucous leukoplakia

1985 • 361 citations

Cyclin D1 and human neoplasia

1998 • 336 citations

Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia

1995 • 307 citations

Multiple head and neck tumors: evidence for a common clonal origin.

1996 • 284 citations

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

2006 • 274 citations

Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta‐carotene and with beta‐carotene plus vitamin A

1988 • 273 citations

Proliferative verrucous leukoplakia

1997 • 272 citations

Multiple primary cancer in patients with cancer of the head and neck: Second cancer of the head and neck, esophagus, and lung

1989 • 266 citations

Studies in oral leukoplakia: A preliminary report on the period pervalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients

1968 • 245 citations

Observer variability in the histologic assessment of oral premalignant lesions

1995 • 245 citations

Follow-up studies in oral leukoplakia

1977 • 238 citations

Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa

1967 • 234 citations

Randomized Phase III Trial of Low-dose Isotretinoin for Prevention of Second Primary Tumors in Stage I and II Head and Neck Cancer Patients

2006 • 227 citations

A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients

2005 • 224 citations

Epidemiologic and histologic study of oral cancer and leukoplakia among 50,915 villagers in India

1969 • 216 citations

Prevention of Second Primary Tumors With Isotretinoin in Patients With Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up

1994 • 208 citations

p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma

1998 • 199 citations

Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of gujarat, india

1976 • 198 citations

Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinoma

1985 • 185 citations

Response of oral leukoplakias to the administration of vitamin A

1988 • 184 citations

Studies in Oral Leukoplakias. V. Clinical and Histologic Signs of Malignancy

1963 • 183 citations

SECOND RESPIRATORY AND UPPER DIGESTIVE TRACT CANCERS AFTER ORAL CANCER

1981 • 181 citations

A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization.

2000 • 176 citations

An epidemiologic assessment of cancer risk in oral precancerous lesions in India with special reference to nodular leukoplakia

1989 • 170 citations

Phenotype and Genotype of Advanced Premalignant Head and Neck Lesions After Chemopreventive Therapy

1998 • 166 citations

An Expanded Risk Prediction Model for Lung Cancer

2008 • 160 citations

Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment

1997 • 155 citations

Molecular targets for cancer chemoprevention

2009 • 148 citations

An Attenuated Adenovirus, ONYX-015, As Mouthwash Therapy for Premalignant Oral Dysplasia

2003 • 143 citations

Longitudinal studies in oral leukoplakias

1972 • 141 citations

Malignant transformation in oral leukoplakia

1987 • 141 citations

A follow-up study of sixty-one oral dysplastic precancerous lesions in Indian villagers

1977 • 140 citations

Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma

2003 • 135 citations

Proliferative verrucous leukoplakia

1996 • 134 citations

Clinical modulation of oral leukoplakia and protease activity by Bowman-Birk inhibitor concentrate in a phase IIa chemoprevention trial.

2000 • 134 citations

The clinical features and risk of malignant transformation in sublingual keratosis

1978 • 133 citations

Synchronous oral carcinomas: independent or common clonal origin?

1998 • 128 citations

Prevention of second primary tumours with etretinate in squamous cell carcinoma of the oral cavity and oropharynx. Results of a multicentric double-blind randomised study

1994 • 117 citations

Overexpression of cyclin D1 enhances gene amplification.

1996 • 114 citations

3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites.

2002 • 113 citations

Randomized trial of supplemental beta-carotene to prevent second head and neck cancer.

2001 • 113 citations

Pilot Randomized Phase II Study of Celecoxib in Oral Premalignant Lesions

2008 • 105 citations

Common clonal origin of synchronous primary head and neck squamous cell carcinomas: Analysis by tumor karyotypes and fluorescence in situ hybridization

1995 • 99 citations

Cyclin D1 Genotype, Response to Biochemoprevention, and Progression Rate to Upper Aerodigestive Tract Cancer

2003 • 99 citations

Multiple oral squamous epithelial lesions: are they genetically related?

2001 • 98 citations

Randomized, Double-Blind, Placebo-Controlled Phase IIB Trial of the Cyclooxygenase Inhibitor Ketorolac as an Oral Rinse in Oropharyngeal Leukoplakia

2004 • 97 citations

Randomized Trial of 13-cis Retinoic Acid Compared With Retinyl Palmitate With or Without Beta-Carotene in Oral Premalignancy

2008 • 96 citations

Molecular support for field cancerization in the head and neck

1998 • 95 citations

Low-Dose Isotretinoin Versus -Carotene to Prevent Oral Carcinogenesis: Long-term Follow-up

1997 • 94 citations

Allelic imbalance at chromosomal loci implicated in the pathogenesis of oral precancer, cumulative loss and its relationship with progression to cancer

1998 • 91 citations

Oral leukoplakia in relation to tobacco habits

1972 • 90 citations

Oral Epithelium as a Surrogate Tissue for Assessing Smoking-Induced Molecular Alterations in the Lungs

2008 • 89 citations

Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development.

2001 • 88 citations

Randomized trial of fenretinide (4‐HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: Long‐term results

2005 • 80 citations

A clinical and histopathologic study of oral leukoplakia.

1961 • 71 citations

Potentially malignant oral lesions in Northern Ireland: size (extent) matters

2003 • 55 citations

Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia

2006 • 50 citations

Cyclin D1 and Cancer Development in Laryngeal Premalignancy Patients

2009 • 46 citations

High-Dose Fenretinide in Oral Leukoplakia

2009 • 41 citations

Flow cytometric analysis of nuclear DNA content in oral leukoplakia: relation to clinicopathologic findings

1995 • 39 citations

Epithelial dysplasia of the oral cavity and lips

1988 • 36 citations

Hyperfrequency of pulmonary cancer in a population of 415 patients treated for laryngeal cancer

1987 • 35 citations

Role of smoking in floor of the mouth leukoplakias.

1972 • 34 citations

Second cancer following cancer of the respiratory system in Denmark, 1943-80.

1985 • 26 citations

Progressive and regressive changes in Hungarian oral leukoplakias in the course of longitudinal studies

1975 • 25 citations

Second primary cancers in laryngeal cancer patients in Slovenia, 1961–1996

2002 • 16 citations

Role of smoking in floor of the mouth leukoplakias

1972 • 6 citations