In Vitro Negative Selection of Viral Superantigen-Reactive Thymocytes by Thymic Dendritic Cells

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction.

1980 • 329 citations

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

1991 • 277 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Superantigens of Mouse Mammary Tumor Virus

1995 • 196 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells.

1991 • 187 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens.

1994 • 114 citations

Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymus.

1991 • 113 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.

1991 • 82 citations

Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions.

1992 • 81 citations

Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.

1989 • 76 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

1992 • 67 citations

Identification of a transitional preapoptotic population of thymocytes

1993 • 66 citations

Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus.

1990 • 54 citations

Functional recognition of in vivo processed self antigen

1994 • 53 citations

Identification of a transitional preapoptotic population of thymocytes.

1993 • 52 citations

Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or β-globin gene promoters

1994 • 48 citations

Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion.

1994 • 47 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

In vitro negative selection of αβ T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells

1993 • 38 citations

Expression and presentation of endogenous mouse mammary tumor virus superantigens by thymic and splenic dendritic cells and B cells.

1996 • 34 citations

Expression of two structurally identical viral superantigens results in thymic elimination at distinct developmental stages.

1994 • 24 citations

A cortisone sensitive CD3^low subset of CD4⁺Ce8^- thymocytes represents an intermediate stage in intrathymic repertoire selection

1992 • 20 citations

Stimulator requirements for primed alloreactive T cells: Macrophages and dendritic cells activate T cells across all genetic disparities

1985 • 18 citations