Cytokines in human lung fibrosis

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 696 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Elevated Levels of NAP-1/Interleukin-8 Are Present in the Airspaces of Patients with the Adult Respiratory Distress Syndrome and Are Associated with Increased Mortality

1992 • 472 citations

Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 • 420 citations

Alveolar macrophages release an insulin-like growth factor I-type molecule.

1988 • 255 citations

Acute lung injury: the role of cytokines in the elicitation of neutrophils.

1994 • 254 citations

Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.

1991 • 249 citations

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

1992 • 249 citations

Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.

1994 • 248 citations

Heterogeneous Proliferative Characteristics of Human Adult Lung Fibroblast Lines and Clonally Derived Fibroblasts from Control and Fibrotic Tissue

1988 • 228 citations

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung.

1984 • 219 citations

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

1983 • 217 citations

Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.

1994 • 186 citations

Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

1990 • 179 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Elevated lnterleukin-1 Release by Human Alveolar Macrophages during the Adult Respiratory Distress Syndrome

1989 • 162 citations

Differential Proliferation of Fibroblasts Cultured from Normal and Fibrotic Human Lungs

1988 • 149 citations

Repopulation of denuded tracheal grafts with normal, preneoplastic, and neoplastic epithelial cell populations.

1978 • 128 citations

Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury.

1993 • 115 citations

Acute lung injury. Pathogenesis of intraalveolar fibrosis.

1991 • 98 citations

Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity.

1994 • 95 citations

Presence of Platelet-derived Growth Factor in Normal and Fibrotic Lung Is Specifically Associated with Interstitial Macrophages, While Both Interstitial Macrophages and Alveolar Epithelial Cells Express the c-sis Proto-oncogene

1991 • 87 citations

Approaches to the treatment of pulmonary fibrosis.

1995 • 81 citations

The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer

1995 • 79 citations

Insulin—like Growth Factor-1 is Partially Responsible for Fibroblast Proliferation Induced by Bronchoalveolar Lavage Fluid from Patients with Systemic Sclerosis

1994 • 68 citations

Recent advances in respiratory medicine

1983 • 66 citations

Approaches to the Treatment of Pulmonary Fibrosis

1995 • 63 citations

Pathogenesis of pulmonary fibrosis: platelet-derived growth factor precedes structural alterations in the Hermansky-Pudlak syndrome.

1994 • 60 citations

Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.

1992 • 55 citations

Identification and partial characterization of angiogenesis bioactivity in the lower respiratory tract after acute lung injury.

1991 • 47 citations

Alveolar macrophages in idiopathic pulmonary fibrosis display a more monocyte-like immunophenotype and an increased release of free oxygen radicals

1991 • 46 citations

Cytokines and Cytokine Networking in the Pathogenesis of Interstitial and Fibrotic Lung Disorders

1993 • 30 citations

Pulmonary gamma interferon production in patients with fibrosing alveolitis.

1990 • 23 citations

Human Granulocyte- and Granulocyte-Macrophage-Colony Stimulating Factors Are Chemotactic and "Competence" Growth Factors for Human Mesenchymal Cells

1993 • 16 citations

Pathogenetic Aspects of The Adult Respiratory Distress Syndrome

1994 • 8 citations