Genetic and Environmental Influences on Obesity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Methodology for Genetic Studies of Twins and Families

1992 • 4,069 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Personal Communication

1997 • 2,763 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Double muscling in cattle due to mutations in the myostatin gene

1997 • 1,970 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Genetic and environmental factors in relative body weight and human adiposity.

1997 • 1,486 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

The Body-Mass Index of Twins Who Have Been Reared Apart

1990 • 1,283 citations

A leptin missense mutation associated with hypogonadism and morbid obesity

1998 • 1,187 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Genetic Mapping of Quantitative Trait Loci for Growth and Fatness in Pigs

1994 • 732 citations

Prader‐Willi syndrome: Current understanding of cause and diagnosis

1990 • 574 citations

The Search for Human Obesity Genes

1998 • 570 citations

How Accurate Is Self-Reported Dietary Energy Intake?

2009 • 564 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

Natural inheritance

1889 • 533 citations

Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats

1997 • 522 citations

Adolescent Obesity Increases Significantly in Second and Third Generation U.S. Immigrants: The National Longitudinal Study of Adolescent Health ,

1998 • 510 citations

The Framingham Study

1980 • 455 citations

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

1997 • 443 citations

The heritability of body mass index among an international sample of monozygotic twins reared apart.

1996 • 422 citations

Multiple Marker Mapping of Quantitative Trait Loci in a Cross Between Outbred Wild Boar and Large White Pigs

1998 • 415 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

Effects of a Traditional Lifestyle on Obesity in Pima Indians

1994 • 387 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

A candidate gene for the mouse mutation tubby

1996 • 346 citations

Polar Overdominance at the Ovine callipyge Locus

1996 • 261 citations

Twin method: Defense of a critical assumption

1979 • 255 citations

Defense of differfing body weight set points in diet-induced obese and resistant rats

1998 • 252 citations

Genome Scan for Human Obesity and Linkage to Markers in 20q13

1999 • 232 citations

Emergenesis: Genetic traits that may not run in families.

1992 • 215 citations

Identification and functional analysis of novel human melanocortin-4 receptor variants.

1999 • 198 citations

Sexual differentiation; Factor determining forms of obesity.

1947 • 194 citations

The nature of environmental influences on weight and obesity: A behavior genetic analysis.

1991 • 188 citations

The mahogany protein is a receptor involved in suppression of obesity

1999 • 185 citations

Autosomal Genomic Scan for Loci Linked to Obesity and Energy Metabolism in Pima Indians

1998 • 182 citations

The Role of the agouti Gene in the Yellow Obese Syndrome ,

1997 • 166 citations

A genetic history of Italy

1988 • 160 citations

THEORETICAL, PRACTICAL, AND SOCIAL ISSUES IN BEHAVIORAL TREATMENTS OF OBESITY

1979 • 157 citations

As Obesity Rates Rise, Experts Struggle to Explain Why

1998 • 154 citations

TULP1 mutation in two extended Dominican kindreds with autosomal recessive Retinitis pigmentosa

1998 • 153 citations

Obesity in pet dogs

1970 • 136 citations

Body fat in identical twins reared apart: Roles for genes and environment

1991 • 124 citations

Body weight patterns among the Chinese: results from the 1989 and 1991 China Health and Nutrition Surveys.

1995 • 123 citations

Behavior Genetic Approaches in Behavioral Medicine

1995 • 118 citations

Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity

1994 • 117 citations

Evidence for independent genetic influences on obesity in middle age.

1992 • 117 citations

Molecular and genetic aspects of obesity

1996 • 117 citations

Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians.

1997 • 112 citations

Twinning: mechanisms and genetic implications

1996 • 109 citations

Risch's lambda values for human obesity.

1996 • 104 citations

The influence of fatness, weight change, slimming history and other lifestyle variables on diet reporting in Danish men and women aged 35-65 years.

1993 • 104 citations

A new class of obesity genes encodes leukocyte adhesion receptors

1997 • 103 citations

The Human Obesity Gene Map: The 1998 Update

1999 • 102 citations

The origins and consequences of obesity

1996 • 96 citations

Body fat and obesity in Japanese Americans

1991 • 96 citations

The origins and consequences of obesity

1997 • 95 citations

Genome Screens Using Linkage Disequilibrium Tests: Optimal Marker Characteristics and Feasibility

1998 • 93 citations

Assortative mating for relative weight: Genetic implications

1996 • 92 citations

Galton's data a century later.

1985 • 88 citations

Genetic and population structure of four Sardinian villages

1985 • 85 citations

Meta-Analysis of Linkage Data under Worst-Case Conditions: A Demonstration Using the Human OB Region

1998 • 82 citations

The genetics of obesity: what have genetic studies told us about the environment.

1997 • 80 citations

Body Build and its Inheritance.

1923 • 79 citations

HLA polymorphisms in Italian bone marrow donors: a regional analysis

1998 • 76 citations

Spouse Correlations in Cardiovascular Risk Factors and the Effect of Marriage Duration

1996 • 67 citations

Relative weight classifications in the assessment of underweight and overweight in the United States.

1992 • 56 citations

Geographic distribution of consanguinity in Europe

1986 • 49 citations

Genetic differentiation among Sardinian villages

1975 • 48 citations

Mixture distributions in human genetics research

1996 • 45 citations

A genetic analysis of relative weight among 4,020 twin pairs, with an emphasis on sex effects.

1994 • 39 citations

Familial obesity and leanness.

1983 • 34 citations

Genetic Influences on Body Mass Index in Early Childhood

1995 • 34 citations

A genetic analysis of relative weight among 4,020 twin pairs, with an emphasis on sex effects.

1994 • 32 citations

Y-chromosome STR loci in Sardinia and continental Italy reveal islander-specific haplotypes.

1997 • 32 citations

The nutritional status of the elderly in Russia, 1992 through 1994.

1996 • 31 citations

Mitochondrial DNA polymorphism in four Sardinian villages

1988 • 28 citations

Genetic variation within the Hereford breed of cattle

1998 • 26 citations

Untitled

1998 • 24 citations

Y-Chromosome STR Loci in Sardinia and Continental Italy Reveal Islander-Specific Haplotypes

1997 • 20 citations

Monogenic models of obesity.

1997 • 18 citations

Genetic Studies of Obesity across the Life Span

1995 • 18 citations

Genetics, geography, and culture: The population of S. Pietro Island (Sardinia, Italy)

1996 • 17 citations

Genetic variation within the Hereford breed of cattle

1998 • 16 citations

Study of the matrimonial structure of the population of Central Sardinia (Italy)

1996 • 14 citations

HLA phenotype and haplotype frequencies in Sardinia (Italy).

1997 • 8 citations

A proposed heuristic for communicating heritability estimates to the general public, with obesity as an example.

1997 • 5 citations

Molecular pathogenesis of Prader-Willi syndrome

1996 • 4 citations

Union Army Slave Appraisal Records from Mississippi, 1863-1865

1991 • 2 citations

Evidence of Commingling in Human Eating Behavior

1993 • 2 citations

Deleted Work

1955 • 0 citations