Monogenic models of obesity.

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1995 • 669 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

1993 • 510 citations

Neomorphic agouti mutations in obese yellow mice

1994 • 437 citations

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

1993 • 428 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

A candidate gene for the mouse mutation tubby

1996 • 346 citations

Obesity, diabetes, and neoplasia in yellow A ^vy /‐ mice: ectopic expression of the agouti gene

1994 • 306 citations

Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

1996 • 289 citations

Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse

1990 • 270 citations

Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat

1997 • 221 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.

1993 • 171 citations

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

1996 • 165 citations

Evaluation of body composition of young obese and lean Zucker rats.

1977 • 136 citations

Onset of genetic obesity in the absence of hyperphagia during the first week of life in the Zucker rat (fa/fa).

1979 • 129 citations

Pleiotropic effects of the mouse lethal yellow (A y) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs

1994 • 108 citations

Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15.

1995 • 106 citations

Cochlear and retinal degeneration in the tubby mouse

1995 • 93 citations

Adaptive Responses of Enzymes of Carbohydrate and Lipid Metabolism to Dietary Alteration in Genetically Obese Zucker Rats (fa/fa)

1978 • 59 citations

Brown adipose tissue thermogenesis, energy balance, and obesity

1984 • 54 citations

Molecular genetics of the ACTH and melanocyte-stimulating hormone receptors

1993 • 44 citations

The development of obesity in genetically diabetic-obese (db/db) mice pair-fed with lean siblings

1980 • 38 citations

Thermogenesis and weight control.

1984 • 35 citations

Indices of Skeletal Muscle Growth in Lean and Obese Zucker Rats

1980 • 32 citations

Development of the hypothermia in obese mice (genotype ob/ob).

1982 • 23 citations

The antiobesity and metabolic activities of LY79771 in obese and normal mice.

1984 • 19 citations

Hypersecretion of Pancreatic Somatostatin in the Obese Zucker Rat: Effects of Food Restriction and Age

1980 • 15 citations

Glucose Metabolism in Isolated Adipocytes from ad Libitum- and Restricted-Fed Lean and Obese Zucker Rats at Two Different Ages

1988 • 13 citations

Effects of a peroxisome proliferator on beta-oxidation and overall energy balance in obese (fa/fa) rats

1991 • 11 citations

Influence of diet composition on obesity, hyperlipemia and liver steatosis in Zucker fa/fa rats pair-fed with Zucker Fa/- rats.

1984 • 11 citations

Peptides in regulation of energy metabolism and body weight.

1996 • 9 citations

Feeding, activity, and body temperature following 6-hydroxydopamine lesions in diabetes (db/db) mice.

1983 • 3 citations

THE NATIONAL CONSERVATION COMMISSION

1908 • 2 citations