Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study.

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

1985 • 663 citations

Amino acid assignment to one of three blood-brain barrier amino acid carriers

1976 • 593 citations

Factors affecting excitatory amino acid release following severe human head injury

1998 • 515 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

Chemoarchitecture of the brain

1987 • 419 citations

Current concepts of brain edema

1995 • 412 citations

Determination of Brain Interstitial Concentrations by Microdialysis

1989 • 410 citations

Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

1993 • 409 citations

Rat brain tumor models in experimental neuro-oncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas.

1998 • 354 citations

Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration

1985 • 299 citations

Multiple Signaling Pathways Regulate Cell Surface Expression and Activity of the Excitatory Amino Acid Carrier 1 Subtype of Glu Transporter in C6 Glioma

1998 • 292 citations

Brain metabolism of branched-chain amino acids

1997 • 241 citations

Measurement of free amino acids in human biological fluids by high-performance liquid chromatography

1984 • 240 citations

The Course of Seizure Disorders in Patients With Malignant Gliomas

1995 • 225 citations

Glutamate‐Mediated Injury in Focal Cerebral Ischemia: The Excitotoxin Hypothesis Revised

1994 • 199 citations

Heterogeneity and Functional Properties of Subtypes of Sodium-Dependent Glutamate Transporters in the Mammalian Central Nervous System

1996 • 187 citations

Uptake of Glutamate and Cystine in C‐6 Glioma Cells and in Cultured Astrocytes

1990 • 179 citations

Astrocytic Swelling Due to Hypotonic or High K⁺Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release

1995 • 161 citations

An ultra rapid and sensitive high-performance liquid chromatographic method for determination of tissue and plasma free amino acids

1985 • 159 citations

Morphological characterization of nitrosourea-induced glioma cell lines and clones

1980 • 146 citations

Simultaneous Measurement of Salicylate Hydroxylation and Glutamate Release in the Penumbral Cortex following Transient Middle Cerebral Artery Occlusion in Rats

1996 • 127 citations

Release of glutamate and of free fatty acids in vasogenic brain edema

1989 • 122 citations

Taurine as osmoregulator and neuromodulator in the brain

1996 • 116 citations

Effects of Microdialysis‐Perfusion with Anisoosmotic Media on Extracellular Amino Acids in the Rat Hippocampus and Skeletal Muscle

1989 • 100 citations

Glutamate-Induced Disruption of the Blood-Brain Barrier in Rats

1996 • 99 citations

Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.

1997 • 99 citations

Dexamethasone Effects on [¹²⁵I]Albumin Distribution in Experimental RG-2 Gliomas and Adjacent Brain

1987 • 94 citations

Astrocytes protect neurons from neurotoxic injury by serum glutamate

1998 • 89 citations

MOLECULAR PHARMACOLOGY AND PHYSIOLOGY OF GLUTAMATE TRANSPORTERS IN THE CENTRAL NERVOUS SYSTEM

1998 • 88 citations

Capillary NMDA receptors regulate blood-brain barrier function and breakdown

1992 • 88 citations

Extracellular Antioxidants and Amino Acids in the Cortex of the Rat: Monitoring by Microdialysis of Early Ischemic Changes

1992 • 86 citations

Evidence that Functional Glutamate Receptors are not Expressed on Rat or Human Cerebromicrovascular Endothelial Cells

1998 • 85 citations

Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter

1996 • 79 citations

Regional metabolism of experimental brain tumors

1986 • 75 citations

Concentrations of Amino Acids in Extracellular Fluid After Opening of the Blood‐Brain Barrier by Intracarotid Infusion of Protamine Sulfate

1994 • 74 citations

Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER)

1996 • 69 citations

Action Potential-generating Cells in Human Glioblastomas

1997 • 66 citations

Regional measurements of blood flow in experimental RG-2 rat gliomas.

1983 • 66 citations

Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells

1997 • 59 citations

Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas.

1983 • 58 citations

The nutritive function of glia is regulated by signals released by neurons

1997 • 57 citations

NMDA- and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow

1996 • 54 citations

The RG2 rat glioma model

1995 • 52 citations

Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate

1995 • 52 citations

Inhibition of lactate export by quercetin acidifies rat glial cells in vitro

1997 • 50 citations

Characterization of cell cycle and biological parameters of transplantable glioma cell lines and clones

1980 • 48 citations

Blood flow and blood-to-tissue transport in 9L gliosarcomas: the role of the brain tumor model in drug delivery research

1991 • 48 citations

Relationships Among Lactate Concentration, Blood Flow and Histopathologic Profiles in Rat C6 Glioma

1996 • 48 citations

Glutamate is transported across the rat blood-brain barrier by a sodium-independent system

1996 • 44 citations

Changes in blood–brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue

1998 • 38 citations

Isogenic transplantation of ethylnitrosourea-induced tumors of the central and peripheral nervous system in two different inbred rat strains

1972 • 31 citations

Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue

1994 • 25 citations

Blockade of AMPA Receptors Reduces Brain Edema following Opening of the Blood—Brain Barrier

1993 • 25 citations

The effects of dexamethasone on experimental brain tumors: I. Transcapillary transport and blood flow in RG-2 rat gliomas

1995 • 15 citations

In vivo Measurement of Regional Brain and Tumor pH Using [¹⁴C]Dimethyloxazolidinedione and Quantitative Autoradiography. II: Characterization of the Extracellular Fluid Compartment Using pH-Sensitive Microelectrodes and [¹⁴C]Sucrose

1986 • 14 citations

The Origin of Lactate in Peritumoral Edema as Measured by Proton-Magnetic Resonance Spectroscopic Imaging

1997 • 10 citations

Lack of evidence for direct involvement of NMDA receptors or polyamines in blood–brain barrier injury after cerebral ischemia in rats

1998 • 9 citations