The Ethical Conduct of Clinical Research Involving Critically Ill Patients in the United States and Canada

Improving the Quality of Reporting of Randomized Controlled Trials

1996 • 2,811 citations

What Makes Clinical Research Ethical?

2000 • 2,305 citations

Equipoise and the Ethics of Clinical Research

1987 • 2,230 citations

A Randomized, Controlled Trial of the Use of Pulmonary-Artery Catheters in High-Risk Surgical Patients

2003 • 1,481 citations

Use of intensive care at the end of life in the United States: An epidemiologic study*

2004 • 1,119 citations

False Hopes and Best Data: Consent to Research and the Therapeutic Misconception

1987 • 918 citations

Current and Projected Workforce Requirements for Care of the Critically Ill and Patients With Pulmonary Disease<SUBTITLE>Can We Meet the Requirements of an Aging Population?</SUBTITLE>

2000 • 914 citations

Association of Funding and Conclusions in Randomized Drug Trials

2003 • 732 citations

Early Use of the Pulmonary Artery Catheter and Outcomes in Patients With Shock and Acute Respiratory Distress Syndrome<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2003 • 664 citations

Relationships Between Authors of Clinical Practice Guidelines and the Pharmaceutical Industry

2002 • 651 citations

Underreporting Research Is Scientific Misconduct

1990 • 542 citations

The Continuing Unethical Conduct of Underpowered Clinical Trials

2002 • 533 citations

A Prospective, Controlled Trial of a Protocol-based Strategy to Discontinue Mechanical Ventilation

2004 • 271 citations

Untitled

2004 • 262 citations

Patients Who Want their Family and Physician to Make Resuscitation Decisions for Them: Observations from SUPPORT and HELP

2000 • 205 citations

Professional Integrity in Clinical Research

1998 • 200 citations

Is Informed Consent Always Necessary for Randomized, Controlled Trials?

1999 • 196 citations

The therapeutic orientation to clinical trials

2012 • 192 citations

The Ethical Analysis of Risk

2000 • 180 citations

Ethics of Phase 1 Oncology Studies

2003 • 179 citations

Protecting Research Subjects — The Crisis at Johns Hopkins

2002 • 173 citations

Do Surrogate Decision Makers Provide Accurate Consent for Intensive Care Research?

2001 • 162 citations

Thyroid Storm

1997 • 128 citations

Data Safety and Monitoring Boards

2004 • 98 citations

Is the concept of informed consent applicable to clinical research involving critically ill patients?

2003 • 92 citations

Research Involving Cognitively Impaired Adults

2003 • 90 citations

How Best to Ventilate? Trial Design and Patient Safety in Studies of the Acute Respiratory Distress Syndrome

2003 • 86 citations

Control group selection in critical care randomized controlled trials evaluating interventional strategies: An ethical assessment*

2004 • 72 citations

Safeguarding Patients in Clinical Trials with High Mortality Rates

2001 • 71 citations

The Ethical Relevance of the Standard of Care in the Design of Clinical Trials

2004 • 62 citations

Protecting Subjects with Decisional Impairment in Research

2003 • 50 citations

The Integral Role of Clinical Research in Clinical Care

2003 • 42 citations

Role of the Data and Safety Monitoring Committee (DSMC)

2002 • 26 citations

Industry, Academia, Investigator

2002 • 20 citations

Ethics, Science, and Oversight of Critical Care Research

2004 • 18 citations

Conflicts of Interest and AJRCCM

2003 • 17 citations

Uses And Abuses Of Long-Term Medicare Cost Estimates

1999 • 17 citations