The Ethical Relevance of the Standard of Care in the Design of Clinical Trials

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

2000 • 11,795 citations

Equipoise and the Ethics of Clinical Research

1987 • 2,230 citations

Ethics and Clinical Research

1966 • 1,851 citations

Unethical Trials of Interventions to Reduce Perinatal Transmission of the Human Immunodeficiency Virus in Developing Countries

1997 • 879 citations

Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues

2000 • 862 citations

The Continuing Unethical Use of Placebo Controls

1994 • 668 citations

The Need for Evidence-Based Medicine

1995 • 629 citations

A Critique of Clinical Equipoise: Therapeutic Misconception in the Ethics of Clinical Trials

2003 • 439 citations

Ethical Complexities of Conducting Research in Developing Countries

1997 • 435 citations

Meta-Analysis of Acute Lung Injury and Acute Respiratory Distress Syndrome Trials Testing Low Tidal Volumes

2002 • 421 citations

The Ethics of Placebo-Controlled Trials — A Middle Ground

2001 • 347 citations

The Need to Revise the Declaration of Helsinki

1999 • 268 citations

The therapeutic orientation to clinical trials

2012 • 192 citations

AZT Trials and Tribulations

1998 • 163 citations

Of Swords and Shields: The Role of Clinical Practice Guidelines in Medical Malpractice Litigation

2001 • 109 citations

Drug prescriptions after acute myocardial infarction: Dosage, compliance, and persistence

2003 • 104 citations

How Best to Ventilate? Trial Design and Patient Safety in Studies of the Acute Respiratory Distress Syndrome

2003 • 86 citations

Placebo-controlled trials in psychiatric research: an ethical perspective

2000 • 74 citations

Placebo-Controls in Short-Term Clinical Trials of Hypertension

2001 • 42 citations