Research Involving Cognitively Impaired Adults

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

2000 • 11,795 citations

Equipoise and the Ethics of Clinical Research

1987 • 2,230 citations

A Randomized, Controlled Trial of the Use of Pulmonary-Artery Catheters in High-Risk Surgical Patients

2003 • 1,481 citations

A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients

1996 • 608 citations

Perceptions of cancer patients and their physicians involved in phase I trials.

1995 • 506 citations

Assessing the Competence of Persons With Alzheimer’s Disease in Providing Informed Consent for Participation in Research

2001 • 252 citations

The Ethical Analysis of Risk

2000 • 180 citations

Do Surrogate Decision Makers Provide Accurate Consent for Intensive Care Research?

2001 • 162 citations

Informed Consent by Proxy

1986 • 153 citations

Scientific Value and Validity as Ethical Requirements for Research: A Proposed Explication

1987 • 136 citations

Alzheimer's Disease Patients' and Caregivers' Capacity, Competency, and Reasons to Enroll in an Early‐Phase Alzheimer's Disease Clinical Trial

2002 • 125 citations

How do AD patients and their caregivers decide whether to enroll in a clinical trial?

2001 • 87 citations

How Best to Ventilate? Trial Design and Patient Safety in Studies of the Acute Respiratory Distress Syndrome

2003 • 86 citations

Cognitively Impaired Subjects

1989 • 77 citations

Views of Potential Subjects Toward Proposed Regulations for Clinical Research With Adults Unable to Consent

2002 • 73 citations

How strictly do dialysis patients want their advance directives followed?

1992 • 49 citations

The controversy over emergency research. A review of the issues and suggestions for a resolution.

1996 • 39 citations

Permission and Assent for Clinical Research in Pediatric Anesthesia

2002 • 29 citations

Consent to research with impaired human subjects: a trial policy for the intramural programs of the National Institutes of Health.

1985 • 26 citations

A Trial Policy for the Intramural Programs of the National Institutes of Health: Consent to Research with Impaired Human Subjects

1985 • 24 citations

Advance Directives in Dementia Research

2001 • 23 citations

A Taxonomy of Value in Clinical Research

2002 • 16 citations

Making Judgments About Patients’ Competence

1998 • 4 citations