Back to search

Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?

Data up to Jan 2025

Published1999
Citations339
References194

Total Citations Per Year

Abstract

References (194)

The Neurology of Eye Movements

2015 • 3,618 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

1995 • 2,101 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

1998 • 1,826 citations

The substantia nigra of the human brain

1999 • 1,598 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

The neostriatal mosaic: multiple levels of compartmental organization

1992 • 1,450 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

The Human Central Nervous System

2007 • 1,202 citations

Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders

1996 • 1,118 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Cytoarchitecture of the Human Brain Stem.

1955 • 922 citations

Greenfield's Neuropathology

1997 • 811 citations

Dementia with Lewy bodies.

2004 • 772 citations

Pathology of Parkinson’s disease

1991 • 674 citations

Neuro‐Psychopharmacology

1962 • 595 citations

Nitric oxide synthase and neuronal vulnerability in parkinson's disease

1996 • 588 citations

The origins of cholinergic and other subcortical afferents to the thalamus in the rat

1987 • 587 citations

Rate of cell death in parkinsonism indicates active neuropathological process

1988 • 545 citations

The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease

1991 • 534 citations

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

1987 • 532 citations

Disease‐specific patterns of locus coeruleus cell loss

1992 • 493 citations

Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

1988 • 493 citations

Neurodegenerative Diseases

1994 • 492 citations

High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor

1997 • 488 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

The Human Central Nervous System

1988 • 462 citations

Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders

1996 • 446 citations

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

1998 • 426 citations

[123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease.

1997 • 412 citations

Pathology and Biology of the Lewy Body

1993 • 394 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

1991 • 393 citations

Dementia in Parkinson disease

1979 • 384 citations

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease

1990 • 376 citations

The pedunculopontine nucleus in Parkinson's disease

1989 • 376 citations

The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease.

1988 • 364 citations

[sup 123 I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease

1996 • 363 citations

Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease

1990 • 347 citations

Efferent projections of nucleus locus coeruleus: Topographic organization of cells of origin demonstrated by three-dimensional reconstruction

1986 • 345 citations

Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra

1989 • 327 citations

Pattern of brain destruction in Parkinson's and Alzheimer's diseases

1996 • 325 citations

Brain Cholinergic Systems

1990 • 324 citations

Movement Disorders 2

1988 • 324 citations

Glutamate and Parkinson’s disease

1996 • 315 citations

Cytoarchitecture of the Human Brain Stem

1983 • 302 citations

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons.

1997 • 286 citations

Dementia in idiopathic Parkinson's disease

1984 • 276 citations

Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor

1998 • 269 citations

The Dopamine Receptors

1997 • 260 citations

Aggregation of Neurofilament and α-Synuclein Proteins in Lewy Bodies

1998 • 254 citations

Midbrain dopaminergic neurons (nuclei A8, A9, and A10): Three‐dimensional reconstruction in the rat

1993 • 250 citations

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

1998 • 240 citations

Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease

1988 • 240 citations

Neurochemical Correlates of Major Depression in Primary Dementia

1990 • 233 citations

Dopamine, 6-hydroxydopamine, iron, and dioxygen — their mutual interactions and possible implication in the development of Parkinson's disease

1996 • 232 citations

Activation mapping in essential tremor with functional magnetic resonance imaging

1997 • 227 citations

Nerve growth factor in Alzheimerʼs disease: defective retrograde transport to nucleus basalis

1995 • 226 citations

Cell death mechanisms in Parkinson's disease

2000 • 224 citations

Alterations of dopaminergic and noradrenergic innervations in motor cortex in parkinson's disease

1991 • 220 citations

Identification and characterization of neurons with tremor-frequency activity in human globus pallidus

1997 • 219 citations

Cholinergic Transmitter and Neurotrophic Activities in Lewy Body Dementia

1993 • 212 citations

High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases

1997 • 211 citations

Telencephalic Projections of the A8 Dopamine Cell Group

1988 • 208 citations

ABNORMAL OCULAR MOVEMENTS IN PARKINSON'S DISEASE

1989 • 204 citations

Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease

1993 • 201 citations

Immunochemical analysis of dopamine transporter protein in Parkinson's disease

1997 • 200 citations

Neuronal vulnerability in Parkinson’s disease

1997 • 198 citations

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

1995 • 183 citations

Contribution of somal Lewy bodies to neuronal death

1997 • 178 citations

Mechanisms of synaptic dysfunction in Alzheimer's disease.

1995 • 170 citations

[ 11 C]RTI‐32 PET studies of the dopamine transporter in early dopa‐naive Parkinson's disease

1997 • 168 citations

In vivo studies on striatal dopamine D 1 and D 2 site binding in L-dopa-treated Parkinson's disease patients with and without dyskinesias

1997 • 164 citations

The locus ceruleus and dementia in Parkinson's disease

1993 • 164 citations

The pathology of the human locus ceruleus.

1983 • 163 citations

Glial Cell Line‐Derived Neurotrophic Growth Factor Inhibits Apoptotic Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture

1998 • 159 citations

Primate striatonigral projections: A comparison of the sensorimotor‐related striatum and the ventral striatum

1994 • 159 citations

Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type

1985 • 157 citations

BRAIN CONTROL OF CONJUGATE HORJZONTAL AND VERTICAL EYE MOVEMENTS

1980 • 155 citations

Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons

1994 • 155 citations

Dopamine receptor interactions: some implications for the treatment of Parkinson's disease

1992 • 154 citations

Mental dysfunction in Parkinson's disease

1998 • 153 citations

Phosphorylation of the High Molecular Weight Neurofilament Protein (NF-H) by Cdk5 and p35

1996 • 148 citations

On the question of apoptosis in the parkinsonian substantia nigra

1997 • 145 citations

Regional changes in [18F]dopa metabolism in the striatum in Parkinson's disease

1996 • 145 citations

Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts

1997 • 144 citations

Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [ 123 I]β-CIT SPECT

1997 • 142 citations

The role of transition metals in the pathogenesis of Parkinson's disease

1995 • 135 citations

Hypothesis: The role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease

1998 • 132 citations

Mineral and Metal Neurotoxicology

1996 • 130 citations

Synaptic Connections Between Spiny Neurons of the Direct and Indirect Pathways in the Neostriatum of the Rat: Evidence from Dopamine Receptor and Neuropeptide Immunostaining

1996 • 129 citations

Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis

1995 • 127 citations

Specific A10 Dopaminergic Nuclei in the Midbrain Degenerate in Parkinson's Disease

1997 • 126 citations

Alzheimer's disease and related disorders

1990 • 125 citations

The human amygdaloid complex: A cytologic and histochemical atlas using Nissl, myelin, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate diaphorase staining

1990 • 122 citations

Neostriatal mechanisms in Parkinson's disease

1998 • 121 citations

Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in parkinson's disease

1994 • 116 citations

The nigrostriatal system in Parkinson's disease.

1990 • 114 citations

Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride

1995 • 111 citations

The metabolic anatomy of tremor in Parkinson's disease

1998 • 111 citations

Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with parkinson's, alzheimer's with parkinsonism, and alzheimer's disease

1997 • 110 citations

Relationships between Lewy bodies and pale bodies in Parkinson's disease

1992 • 108 citations

Usefulness of pallidotomy in advanced Parkinson's disease.

1997 • 107 citations

The pathophysiology of chorea/ballism and Parkinsonism

1995 • 102 citations

Differences in the reduced 18F-Dopa uptakes of the caudate and the putamen in Parkinson's disease: correlations with the three main symptoms

1996 • 102 citations

Preservation of hypothalamic dopaminergic neurons in Parkinson's disease

1985 • 101 citations

Functional Effects of Striatal Dysfunction in Parkinson Disease

1997 • 101 citations

Midbrain neuropathology in idiopathic Parkinson's disease and diffuse Lewy body disease

1996 • 100 citations

Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease

1995 • 99 citations

THE PATHOLOGY OF CERTAIN MEDULLARY NUCLEI IN PARKINSONISM

1963 • 98 citations

Functional imaging in relation to parkinsonian syndromes

1993 • 98 citations

A positron emission tomography study of primary orthostatic tremor

1996 • 98 citations

Mesencephalic cholinergic nuclei in progressive supranuclear palsy

1991 • 90 citations

Oxidative stress in Parkinson's disease

1995 • 87 citations

Morphological substrates of dementia in parkinsonism A critical update

1997 • 86 citations

Distribution of monoaminergic, cholinergic, and GABAergic markers in the human cerebral cortex

1989 • 83 citations

The mesencephalic centre controlling locomotion in the rat

1989 • 80 citations

Chronic thalamic stimulation with three-dimensional MR stereotactic guidance.

1997 • 79 citations

Neuron loss and shrinkage in the amygdala in Alzheimer's disease

1994 • 79 citations

Does monoamine oxidase type B play a role in dopaminergic nerve cell death in Parkinson's disease?

1996 • 74 citations

Loss of C1 and C3 epinephrine‐synthesizing neurons in the medulla oblongata in parkinson's disease

1993 • 74 citations

The basal nucleus of Meynert in idiopathic Parkinson's disease

2009 • 73 citations

Cognitive Dysfunction and Impaired Organization of Complex Motility in Degenerative Parkinsonian Syndromes

1998 • 72 citations

Dementia in Parkinson's Disease

1994 • 72 citations

Apoptosis in neurodegenerative disorders

1997 • 72 citations

Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease

1993 • 71 citations

Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons

1993 • 70 citations

The Basal Ganglia Iv: New Ideas And Data On Structure And Function

2011 • 70 citations

Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains

1994 • 69 citations

Inhibition of voluntary activity by thalamic stimulation in humans: Relevance for the control of tremor

1997 • 69 citations

The Subthalamic Nucleus in Parkinsonʼs Disease and Progressive Supranuclear Palsy

1997 • 68 citations

Calbindin‐D28K in the basal ganglia of patients with parkinsonism

1992 • 66 citations

Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes

1996 • 66 citations

Neuronal cell loss of the striatonigral system in multiple system atrophy

1993 • 65 citations

Tremor control after pallidotomy in patients with Parkinson's disease: correlation with microrecording findings

1997 • 64 citations

Caudate nucleus pathology in Parkinson's disease: ultrastructural and biochemical findings in biopsy material

1992 • 63 citations

Noradrengic mechanisms in Parkion's disease

1993 • 63 citations

Progressive Supranuclear Palsy Affects both the Substantia Nigra Pars Compacta and Reticulata

1997 • 59 citations

Striatal efferent involvement and its correlation to levodopa efficacy in patients with multiple system atrophy

1996 • 59 citations

Substantia Nigra Pars Reticulata Neurons in Parkinson's Disease

1996 • 59 citations

Pathology of Parkinson’s Syndrome

1989 • 59 citations

Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease

1990 • 58 citations

The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role?

1990 • 57 citations

Loss of dopamine-D2 receptor binding sites in Parkinsonian plus syndromes.

1998 • 57 citations

Medial nigral dopamine neurons have rich neurotrophin support in humans

1998 • 57 citations

Function and dysfunction in the basal ganglia

1990 • 57 citations

Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography

1996 • 56 citations

CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies.

1978 • 56 citations

Positron emission tomography studies on the dopaminergic system and striatal opioid binding in the olivopontocerebellar atrophy variant of multiple system atrophy

1995 • 56 citations

Molecular mechanisms for neurodegeneration. Synergism between reactive oxygen species, calcium, and excitotoxic amino acids.

1996 • 55 citations

Phosphorylation of Neuronal Cytoskeletal Proteins in Alzheimer's Disease and Lewy Body Dementiasa

1994 • 53 citations

The rostral mesencephalon in Parkinson's disease and Alzheimer's disease

1985 • 52 citations

The Basal Ganglia Related System of Primates: Definition, Description and Informational Analysis

1994 • 52 citations

PET imaging of neocortical monoaminergic terminals in Parkinson's disease

1995 • 51 citations

Stereotactic thalamotomy in tremor‐dominant Parkinson's disease: An H215O PET motor activation study

1997 • 51 citations

Drugs for the Treatment of Parkinson’s Disease

1989 • 51 citations

Biological correlates of clinical heterogeneity in primary dementia

1992 • 50 citations

Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration

1996 • 49 citations

The organization of nucleus tegmenti pedunculopontinus neurons projecting to basal ganglia and thalamus: a retrograde fluorescent double labeling study in the rat

1987 • 48 citations

Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease

1996 • 48 citations

Increased fragility of erythrocytes from amyotrophic lateral sclerosis (ALS) patients provoked by mechanical stress

1984 • 48 citations

A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease

1996 • 48 citations

Monoclonal antibodies to purified cortical lewy bodies recognize the mid‐size neurofilament subunit

1997 • 47 citations

Neuropathology of Movement Disorders

2017 • 44 citations

Depression and dementia in Parkinson's disease. Catecholamine changes in the locus ceruleus, a basis for therapy.

1993 • 40 citations

Defects of cytochrome c oxidase in the substantia nigra of Parkinson's disease: An immunohistochemical and morphometric study

1997 • 39 citations

Pallidal and Thalamic Surgery for Parkinson's Disease

1997 • 33 citations

Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes

1990 • 33 citations

Dementia in Parkinson's disease. Morphometric data.

1993 • 32 citations

Biochemical Neuroanatomy of the Basal Ganglia

1989 • 32 citations

Cognitive impairment in Parkinson's disease

1998 • 29 citations

Neuropathology of Movement Disorders

1998 • 29 citations

[Cognitive functions and the basal ganglia: the model of Parkinson disease].

1994 • 27 citations

Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains

1998 • 27 citations

IBZM- and CIT-SPECT of the dopaminergic system in parkinsonism

1997 • 26 citations

Total biopterin levels in the ventricular CSF of patients with Parkinson's disease: A comparison between akineto-rigid and tremor types

1991 • 24 citations

Handbuch der Gerontopsychiatrie

1996 • 23 citations

Loss of non-phosphorylated neurofilament immunoreactivity, with preservation of tyrosine hydroxylase, in surviving substantia nigra neurons in Parkinson's disease.

1994 • 21 citations

Posteroventral Medial Pallidotomy in Levodopa-Unresponsive Parkinsonism

1997 • 20 citations

Neurosurgical interventions in the treatment of idiopathic Parkinson disease: neurostimulation and neural implantation

1999 • 19 citations

Selective increase in somatostatin mRNA expression in human basal ganglia in Parkinson's disease

1997 • 19 citations

Reversible supranuclear ophthalmoplegia associated with Parkinsonism.

1980 • 18 citations

Neuroreceptor imaging: new developments in PET and SPECT imaging of neuroreceptor binding (including dopamine transporters, vesicle transporters and post synaptic receptor sites)

1998 • 17 citations

Parkinsonian Tremor is Associated with Low Frequency Neuronal Oscillations in Selective Loops of the Basal Ganglia

1994 • 17 citations

Dementia with Lewy bodies: relationships to Parkinson's and Alzheimer's diseases

1996 • 15 citations

Resting tremor only: a variant of Parkinson's disease or of essential tremor

1995 • 14 citations

Striatal Dopamine transporter in Parkinson's disease: A Study With a New Radioligand, [123I]B-CIT-FP

1997 • 9 citations

Die Bewegungsstörungen im höheren Lebensalter

1996 • 4 citations

Pallidotomy: Editorial review

1997 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...