THE INDUCTION OF CLASS I AND II MAJOR HISTOCOMPATIBILITY COMPLEX BY ALLOGENEIC STIMULATION IS DEPENDENT ON THE TRANSCRIPTION FACTOR INTERFERON REGULATORY FACTOR 1 (IRF-1)

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril (Iodogen)

1981 • 1,135 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

Regulation of MHC gene expression

1993 • 215 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons.

1994 • 126 citations

NFκB and Interferon Regulatory Factor 1 Physically Interact and Synergistically Induce Major Histocompatibility Class I Gene Expression

1995 • 121 citations

The delayed-type hypersensitivity reaction is dependent on IL-8. Inhibition of a tuberculin skin reaction by an anti-IL-8 monoclonal antibody.

1995 • 119 citations

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1)

1992 • 108 citations

Interferon-gamma induction by lipopolysaccharide: dependence on interleukin 2 and macrophages.

1986 • 100 citations

Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells.

1985 • 89 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene.

1989 • 84 citations

Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues.

1992 • 76 citations

Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes

1995 • 73 citations

Local T cell responses induce widespread MHC expression. Evidence that IFN-gamma induces its own expression in remote sites.

1992 • 72 citations

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

1989 • 71 citations

Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma.

1995 • 65 citations

IDENTIFICATION OF A CALCIUM-INDUCIBLE, CYCLOSPORINE-SENSITIVE ELEMENT IN THE IFN-?? PROMOTER THAT IS A POTENTIAL NFAT BINDING SITE1

1996 • 61 citations

The immunohistochemical demonstration of major histocompatibility antigens in the human kidney using monoclonal antibodies

1982 • 60 citations

Association with beta 2-microglobulin controls the expression of transfected human class I genes.

1987 • 59 citations

Regulation of MHC expression in vivo. Bacterial lipopolysaccharide induces class I and II MHC products in mouse tissues by a T cell-independent, cyclosporine-sensitive mechanism.

1988 • 59 citations

clRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA

1995 • 56 citations

Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC gene.

1990 • 52 citations

Regulation of MHC expression in vivo. II. IFN-alpha/beta inducers and recombinant IFN-alpha modulate MHC antigen expression in mouse tissues.

1989 • 51 citations

CORRELATION OF FETAL KIDNEY AND TESTIS CONGENIC GRAFT SURVIVAL WITH REDUCED MAJOR HISTOCOMPATIBILITY COMPLEX BURDEN

1989 • 45 citations

Changes in NF-kappa B and ISGF3 DNA binding activities are responsible for differences in MHC and beta-IFN gene expression in Ad5- versus Ad12-transformed cells.

1991 • 43 citations

Increased class I and class II MHC products and mRNA in kidneys of MRL-lpr/lpr mice during autoimmune nephritis and inhibition by cyclosporine.

1988 • 40 citations

Systemic immunologic stimuli increase class I and II antigen expression in mouse kidney.

1985 • 39 citations

Transcriptional control of MHC class I and beta 2-microglobulin genes in vivo.

1993 • 29 citations

REGULATION OF MHC TRANSCRIPTION

1990 • 27 citations

EFFECTS OF CYCLOSPORINE ON SYSTEMIC MHC EXPRESSION

1988 • 26 citations

Expression of a class I MHC transgene: regulation by a tissue-specific negative regulatory DNA sequence element.

1990 • 25 citations

INDUCTION OF MHC CLASS II EXPRESSION IN RECIPIENT TISSUES CAUSED BY ALLOGRAFT REJECTION

1990 • 20 citations