Ontogeny of T Cells

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

1980 • 1,668 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

1977 • 563 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin

1976 • 513 citations

EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

1967 • 504 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody.

1981 • 371 citations

Regulation of Cellular and Humoral Immune Responses by T-cell Subclasses

1977 • 368 citations

THYMUS CELL MIGRATION

1967 • 356 citations

T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants

1984 • 344 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

Intrathymic and Extrathymic T Cell Maturation

1978 • 327 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

Location of T cell and major histocompatibility complex antigens in the human thymus.

1980 • 286 citations

The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

1983 • 264 citations

Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry.

1985 • 261 citations

DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTS

1973 • 252 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

RECIRCULATION OF LYMPHOCYTES*

1964 • 233 citations

Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes.

1975 • 220 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

STUDIES ON THE DIFFERENTIATION OF THYMUS-DERIVED LYMPHOCYTES

1970 • 198 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

Expression of MHC Antigens by Mouse Thymic Dendritic Cells

1979 • 191 citations

Interrelationships of myeloid and lymphoid cells: studies with chromosome-marked cells transfused into lethally irradiated mice

1966 • 186 citations

Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets

1984 • 179 citations

Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers.

1983 • 178 citations

Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quail thymus during embryonic and perinatal life.

1982 • 172 citations

Isolation Characterization, and Utilization of T Lymphocyte Clones

1982 • 171 citations

The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro.

1978 • 166 citations

Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice.

1981 • 165 citations

INDUCTION OF T LYMPHOCYTES FROM PRECURSOR CELLS IN VITRO BY A PRODUCT OF THE THYMUS

1973 • 163 citations

Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.

1984 • 154 citations

Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.

1976 • 154 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.

1978 • 151 citations

Bone marrow cells give rise to distinct cell clones within the thymus

1984 • 146 citations

A defect in the antigen-presenting function of macrophages from neonatal mice

1979 • 145 citations

CHARACTERIZATION OF SPLENIC LYMPHOID CELLS IN FETAL AND NEWBORN MICE

1973 • 143 citations

Current concepts in human immunology and cancer immunomodulation

1981 • 141 citations

Thymus-Derived Peripheral Lymphocytes from Human Newborns Inhibit Division of Their Mothers' Lymphocytes

1976 • 131 citations

Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.

1984 • 131 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

Regulation of B cell differentiation by T cell subsets defined with monoclonal OKT4 and OKT8 antibodies in human cord blood.

1981 • 122 citations

Thy‐1 determinants are present on many murine hematopoietic Cells other than T Cells

1982 • 121 citations

B and T cells in immune recognition

1977 • 121 citations

Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs.

1983 • 113 citations

Characterization of immature T cell subpopulations in neonatal blood

1984 • 113 citations

Ontogeny of cellular immunity in the human fetus

1974 • 112 citations

Seeding of the 10-day mouse embryo thymic rudiment by lymphocyte precursors in vitro.

1981 • 109 citations

Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells.

1982 • 109 citations

Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

1972 • 106 citations

T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses.

1984 • 105 citations

ON THE SPARSE SEEDING OF BONE MARROW AND THYMUS IN RADIATION CHIMAERAS

1975 • 103 citations

Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses.

1976 • 102 citations

A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes

1984 • 102 citations

Two Main Features of T-Cell Development: Thymus Traffic and Postthymic Maturation

1977 • 101 citations

Five types of lymphocytes (lg⁻ θ⁻, lg⁻ θ⁺ weak, lg⁻ θ^+strong, lg⁺ θ⁻ and lg⁺ θ⁺) characterized by double immunofluorescence and electrophoretic mobility Organ distribution in normal and nude mice

1975 • 97 citations

AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS

1966 • 95 citations

Development of Mitogen Responding T Cells and Natural Killer Cells in the Human Fetus

1981 • 95 citations

Developmental relationships between vitelline and intra-embryonic haemopoiesis studied in avian ‘yolk sac chimaeras’

1978 • 92 citations

T-cell function and specificity in athymic mice

1983 • 90 citations

The glycolipid asialo GM1 as a new differentiation antigen of fetal thymocytes.

1980 • 90 citations

Hematopoietic thymocyte precursors: II. Properties of the precursors.

1977 • 88 citations

Significance of Self‐Recognition and Interleukin‐2 for Immunoregulation, Autoimmunity and Cancer

1982 • 87 citations

Newborn T cell suppression: early appearance, maintenance in culture, and lack of growth factor suppression.

1981 • 84 citations

The functional capabilities of cells leaving the thymus.

1984 • 84 citations

Isogeneic Lymphocyte Interaction: Recognition of Self Antigens by Cells of the Neonatal Thymus

1970 • 82 citations

Immune-deficient animals

1985 • 82 citations

STUDIES ON THYMUS FUNCTION

1970 • 79 citations

An in vivo assay for thymus-homing bone marrow cells

1981 • 79 citations

Post-thymic T lymphocyte maturation during ontogenesis.

1981 • 79 citations

Enumeration of IL 2-secreting helper T cells by limiting dilution analysis, and demonstration of unexpectedly high levels of IL 2 production per responding cell.

1982 • 77 citations

Lyt 1+23− cells appear in the thymus before Lyt 123+ cells

1981 • 77 citations

Control of macrophage Ia expression in neonatal mice--role of a splenic suppressor cell.

1982 • 77 citations

In Vitro Generation of Suppressor Cell Activity: Suppression of in vitro Induction of Cell-Mediated Cytotoxicity

1976 • 77 citations

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.

1983 • 74 citations

Nude Mouse Embryo: Ectodermal Nature of the Primordial Thymic Defect

1975 • 72 citations

During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.

1980 • 71 citations

Flow microfluorometric analysis of mouse thymus development in vivo and in vitro

1983 • 71 citations

Development of cell-mediated lympholysis in human foetal blood lymphocytes.

1980 • 71 citations

Expression of Thy-1 antigen is not limited to T cells in cultures of mouse hemopoietic cells.

1982 • 70 citations

Intrathymic events in the differentiation of T lymphocytes: a continuing enigma

1983 • 69 citations

Thymus cell migration: cells migrating from thymus to peripheral lymphoid organs have a "mature" phenotype.

1982 • 69 citations

Regulation of Immune Functions in the Fetus and Newborn1

2015 • 68 citations

The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.

1984 • 67 citations

Lyt markers on thymus cell migrants

1978 • 67 citations

Detection of Thy‐1, T‐200, Lyt‐1 and Lyt‐2‐bearing cells in the developing lymphoid organs of the mouse embryo in vivo and in vitro

1982 • 64 citations

Normal and Neoplastic Maturation of T-lineage Lymphocytes

1977 • 64 citations

Thymus-Repopulating Capacity of Cells that Can be Induced to Differentiate to T Cells in Vitro

1975 • 63 citations

The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.

1981 • 61 citations

T-cell receptors generated via mutations are specific for various major histocompatibility antigens

1984 • 61 citations

Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation

1984 • 61 citations

Lymphocyte subpopulations in the neonate: identification of an immature subset of OKT8-positive, OKT3-negative cells.

1983 • 61 citations

Immature T lineage lymphocytes in athymic mice Presence of TL, lifespan and homeostatic regulation

1976 • 59 citations

Differentiation in vitro of Lyt 2+ thymocytes from embryonic Lyt 2− precursors

1983 • 59 citations

Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation

1985 • 59 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

Embryology of the Lymphoid System

2015 • 57 citations

Increased reactivity of responding cells in the mixed lymphocyte reaction by a thymic humoral factor

1975 • 56 citations

Non‐T cell nature of the naturally occurring, spleen‐associated suppressor cells present in the newborn mouse

1979 • 56 citations

Changes in suppressor mechanisms during postnatal development in mice.

1978 • 56 citations

Lyt 1 cells respond to la‐bearing macrophages in the murine syngeneic mixed lymphocyte reaction

1980 • 54 citations

STUDIES ON THYMUS FUNCTION

1970 • 54 citations

Thymus cell migration: analysis of thymus emigrants with markers that distinguish medullary thymocytes from peripheral T cells.

1984 • 54 citations

Characteristics of thymus-homing bone marrow cells.

1983 • 53 citations

Suppressor activity in the spleen of neonatal mice

1978 • 53 citations

HUMORAL THYMIC FACTORS INFLUENCING POSTTHYMIC CELLS*

1975 • 51 citations

Ia-dependent interleukin 2 production in syngeneic cellular interactions.

1982 • 50 citations

Dissociation of Responses to Phytohaemagglutinin and Adult Allogeneic Lymphocytes in Human Foetal Lymphoid Tissues

1973 • 49 citations

Suppression of local graft-versus-host reactions by mouse fetal and newborn spleen cells

1976 • 49 citations

Interleukin 2, production in the syngeneic mixed lymphocyte reaction

1981 • 48 citations

Formation and maturation of bone marrow lymphocytes.

1975 • 47 citations

Peanut lectin binding as a marker for activated T-lineage lymphocytes.

1982 • 47 citations

The Role of the Histocompatibility Gene Complex in Lymphocyte Differentiation

1977 • 46 citations

Discrepancy in expression ability of Tac antigen and Ia determinants defined by monoclonal antibodies on activated or cultured cord blood T lymphocytes.

1982 • 46 citations

Committed T lymphocyte stem cells of rats. Characterization by surface W3/13 antigen and radiosensitivity.

1981 • 46 citations

Cytokinetics and regulation of progenitor cells

1966 • 45 citations

Die Entwicklung des thyreo-parathyreo-thymischen Systems der weißen Maus

1935 • 45 citations

T‐Cell development in the absence of a thymus: The number, the phenotype, and the functional capacity of T lymphocytes in nude mice

1984 • 44 citations

Studies of the phylogeny and ontogeny of the specialized lymphatic tissue venules.

1969 • 43 citations

Cytolytic T lymphocyte precursor cells in congenitally athymic C57BL/6 nu/nu mice: quantitation, enrichment, and specificity.

1981 • 40 citations

Ontogeny of mouse T-lymphocyte function

1975 • 40 citations

Interleukin-2 induction of hapten-specific cytolytic T cells in nude mice.

1981 • 38 citations

Ontogeny of murine macrophages: functions related to antigen presentation

1982 • 37 citations

Ontogeny of adherent cells. I. Distribution and ontogeny of A cells participating in the response to sheep erythrocytes in vitro

1976 • 36 citations

Suppression of Stimulation in Mixed Leukocyte Culture by Newborn Splenic Lymphocytes in the Mouse

1977 • 35 citations

Development of cytotoxic T lymphocyte precursors in the absence of the thymus

1980 • 34 citations

Analysis by limiting dilution of interleukin 2-producing T cells in murine ontogeny

1983 • 34 citations

Expression of Thymocyte Surface Alloantigens in the Fetal Mouse Thymus in vivo and in Organ Culture

1977 • 33 citations

Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursors.

1983 • 32 citations

Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter.

1982 • 32 citations

Intrathymic differentiation: Some unanswered questions

1985 • 32 citations

Presence of Antigen-Binding Cells for Five Diverse Antigens at the Onset of Lymphoid Development: Lack of Evidence for Somatic Diversification during Ontogeny

1974 • 31 citations

Characterization of murine newborn inhibitory T lymphocytes: functional and phenotypic comparison with an adult T cell subset activatedin vitro by alphafetoprotein

1981 • 30 citations

Hematopoietic thymocyte precursors: IV. Enrichment of the precursors and evidence for heterogeneity.

1978 • 30 citations

Acquisition of the T cell repertoire

1978 • 30 citations

Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.

1982 • 29 citations

FETAL SUPPRESSOR CELLS

1977 • 29 citations

FREQUENCY OF ALLOREACTIVE CYTOTOXIC T CELL PRECURSORS IN THE MOUSE THYMUS AND SPLEEN DURING ONTOGENY

1979 • 28 citations

Development and Loss of Virus‐Specific Thymic Competence in Bone Marrow Radiation Chimeras and Normal Mice

1981 • 27 citations

Generation of cytolytic T lymphocytes in thymectomized, irradiated, and bone marrow-reconstituted mice.

1982 • 27 citations

Predominance of Theta-Positive Lymphocytes in Gut-Associated and Peripheral Lymphoid Tissues of Newborn Mice

1973 • 27 citations

Suppressor factor produced by neonatal mouse spleen cells

1981 • 27 citations

Ontogeny of Acquired Immunity. A Ciba Foundation Symposium.

1973 • 27 citations

COMPARTMENTS AND CELL FLOWS WITHIN THE MOUSE HAEMOPOIETIC SYSTEM II. ESTIMATED RATES OF INTERCHANGE

1975 • 26 citations

Immunosuppressive activity of murine newborn spleen cells

1979 • 26 citations

MORPHOLOGICAL AND FUNCTIONAL STUDIES OF FETAL THYMUS TRANSPLANTS IN MICE

1972 • 24 citations

Functional Development of the Interacting Cells in the Immune Response

1972 • 24 citations

The development of antigen-binding lymphocytes in foetal tissues.

1972 • 23 citations

The size of functional T-lymphocyte pools within thymic medullary and cortical cell subsets.

1983 • 23 citations

Development of T Cell Repertoire in the Human and the Sheep Fetus

1978 • 22 citations

T and B Lymphocytes: Recognition and Function

1979 • 21 citations

Ontogeny of culture-generated suppressor cells.

1979 • 21 citations

Differentiation of functionally active mouse T-lymphocytes from functionally inactive bone marrow precursors.

1977 • 20 citations

The acquisition of receptors for peanut agglutinin by peanut agglutinin-negative thymocytes and peripheral T cells.

1982 • 20 citations

Embryonic mouse thymus development: stem cell entry and differentiation.

1978 • 20 citations

Isolation of a subset of thymocytes inducible for terminal transferase biosynthesis.

1981 • 19 citations

Characterization of in vitro T lymphocyte colonies from normal mouse spleen cells: colonies containing cytotoxic lymphocyte precursors.

1980 • 18 citations

Duration of thymic function.

1974 • 18 citations

Enhanced lymphoid and decreased myeloid reconstituting ability of stem cells from long-term cultures of mouse bone marrow

1980 • 17 citations

The ontogeny of thymic macrophages: Thymic macrophages express Ia from 15 days gestation onwards in the mouse

1984 • 16 citations

Immune reactivity of lymphocytes: Development, expression and control

1976 • 15 citations

Inside the thymus

1984 • 15 citations

Immunosuppressive Activity of Cord Blood Leukocytes

1980 • 15 citations

Immunology: T-cell development in the thymus

1984 • 15 citations

2 Role of Thymic Hormones in T Cell Differentiation

1983 • 14 citations

Use of positively selected Lyt-2+ mouse splenocytes to examine interleukin-2 secretion in responses to alloantigens and to TNP-modified syngeneic cells

1982 • 14 citations

Immunological milestones in ontogeny

1978 • 14 citations

Cellular immune competence in the human fetus

1973 • 14 citations

Culture-generated suppressor cells: Evidence for an adherent cell component

1981 • 14 citations

Naturally Occurring Spleen‐Associated Suppressor Activity of the Newborn Mouse

1984 • 14 citations

Early loss of precursors of CTL and IL 2-producing cells in the development of neonatal tolerance to alloantigens.

1984 • 14 citations

Contribution of thymus lymphocytes to the peripheral lymphoid tissues and the effect of antigen on the rate of cell exit from the thymus

1984 • 13 citations

Generation of cytotoxic T-lymphocyte precursor cells in T-cell colonies grown in vitro

1981 • 13 citations

Ontogeny of macrophage function II. Increase of A-cell activity and decrease of phagocytic activity of peritoneal macrophages during ontogenetic development of immune responsiveness in mice

1978 • 13 citations

Migration of yolk sac cells to thymus grafts: requirement of prior sojourn in bone marrow (or liver?).

1976 • 12 citations

Receptors for peanut agglutinin on a high percentage of human cord-blood lymphocytes: phenotype characterization of peanut-positive cells.

1981 • 10 citations

Limiting dilution analysis of IL-2 production: studies of age, genotype, and regulatory interactions.

1982 • 9 citations

Development of cytotoxic T lymphocyte precursor cells in T cell colonies grown in vitro.

1982 • 9 citations

Ontogeny of T-cell function: Alloreactivity appears earlier than reactivity against hapten-modified self and interleukin-2 production

1982 • 9 citations

Impaired T-lymphocyte colony formation by cord blood mononuclear cells

1982 • 8 citations

T cell receptors and genes.

1984 • 8 citations

Lymphopoiesis in the rat. I. The effect of pool size on lymphocyte production

1972 • 8 citations

The Identification of Suppressor Cells in the Murine Fetal Liver*

1983 • 7 citations

Studies on the syngeneic mixed lymphocyte reaction. I. The ontogeny of the syngeneic mixed lymphocyte reaction in mice.

1982 • 7 citations

Ontogeny of anti-self-trinitrophenyl cytotoxic T-cell responses.

1981 • 6 citations

Ontogeny of human lymphocyte function.

1981 • 6 citations

Ontogenetic Aspects

1977 • 4 citations

Lymphocytocidal lymphocyte trapping: organ and species occurrence and increase in the presence of tumor metastasis.

1980 • 2 citations