Dexmedetomidine Fails to Cause Hyperalgesia After Cessation of Chronic Administration

Quantitative assessment of tactile allodynia in the rat paw

1994 • 6,953 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

The opponent-process theory of acquired motivation: The costs of pleasure and the benefits of pain.

1980 • 853 citations

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

1994 • 457 citations

Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

2001 • 337 citations

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

1996 • 327 citations

Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent

2001 • 315 citations

Hyperalgesic responses in methadone maintenance patients

2001 • 301 citations

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

1993 • 282 citations

Evidence for opiate-activated NMDA processes masking opiate analgesia in rats

1999 • 189 citations

Subtype-Specific Intracellular Trafficking of α₂-Adrenergic Receptors

1997 • 181 citations

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

1991 • 177 citations

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine

2001 • 170 citations

A murine model of opioid-induced hyperalgesia

2001 • 156 citations

Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

1994 • 140 citations

Opioid-Induced Hyperalgesia and Incisional Pain

2001 • 131 citations

Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats

1973 • 103 citations

Molecular cloning and in situ hybridization histochemistry for rat μ-opioid receptor

1994 • 95 citations

Spinal infusion of opiate and alpha-2 agonists in rats: tolerance and cross-tolerance studies.

1988 • 89 citations

Hyperalgesia Induced by High-Dose Intrathecal Sufentanil in Neuropathic Pain

1997 • 86 citations

Localization of α2A- and α2B-Adrenergic Receptor Subtypes in Brain

1996 • 79 citations

MorphiDex® (MS:DM) Double-Blind, Multiple-Dose Studies In Chronic Pain Patients

2000 • 69 citations

Ineffectiveness of Dextromethorphan in Cancer Pain

1998 • 65 citations

Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on blood pressure.

1988 • 64 citations

Evidence for crosstolerance to the analgesic effects between morphine and selective ?2-adrenoceptor agonists

1988 • 39 citations

Large-Dose Oral Dextromethorphan as an Adjunct to Patient-Controlled Analgesia with Morphine after Knee Surgery

2001 • 38 citations

Narcotic Withdrawal Syndrome in Young Adults After the Therapeutic Use of Opiates

1986 • 38 citations

Comparison of subjective and objective analgesic effects of intravenous and intrathecal morphine in chronic pain patients by heat beam dolorimetry

1989 • 36 citations

Analgesic Action of Acute and Chronic Intraspinally Administered Opiate and α<sub>2</sub>-Adrenergic Agonists in Chronic Neuropathic Pain

1994 • 32 citations

A case of uncommon withdrawal symptoms after a short period of spinal morphine administration

1996 • 29 citations

A withdrawal hyperalgesia test for physical dependence: Evaluation of μ and mixed-partial opioid agonists

1983 • 24 citations

The Effects of the alpha2-Adrenergic Agonist, Dexmedetomidine, in the Spinal Nerve Ligation Model of Neuropathic Pain in Rats

1998 • 22 citations

Sedative but Not Analgesic α2Agonist Tolerance Is Blocked by NMDA Receptor and Nitric Oxide Synthase Inhibitors

2001 • 6 citations

High-dose dihydrocodeine produces hyperalgesia.

1985 • 1 citations