A case of uncommon withdrawal symptoms after a short period of spinal morphine administration

Long-term oral opioid therapy in patients with chronic nonmalignant pain

1992 • 368 citations

Drug Abuse, Dependence, and Addiction in Chronic Pain Patients

1992 • 361 citations

Controversies in the long-term management of analgesic therapy in patients with advanced cancer

1990 • 273 citations

Intrathecal infusional therapies for intractable pain: Patient management guidelines

1993 • 157 citations

Opioid use in the treatment of chronic pain: Assessment of addiction

1993 • 142 citations

Tolerance to morphine. I. Effects on catecholamines in the brain and adrenal glands.

1962 • 141 citations

Altered sexual function and decreased testosterone in patients receiving intraspinal opioids

1994 • 141 citations

Survey of opioid use in chronic nonmalignant pain patients.

1994 • 63 citations

Spinal antagonism of tolerance and dependence induced by systemically administered morphine

1983 • 53 citations

Supraspinal and spinal mediation of naloxone-induced morphine withdrawal in rats

1985 • 51 citations

Intrathecal Clonidine

1985 • 49 citations

Survey of Opioid Use in Chronic Non-Malignant Pain Patients

1995 • 42 citations

Excess release of substance P from the spinal cord of mice during morphine withdrawal and involvement of the enhancement of presynaptic Ca2+ entry

1987 • 22 citations

The chronic intraspinal use of opioid and local anesthetic mixtures for the relief of intractable pain: When all else fails!

1993 • 19 citations

Acute opioid dependence in the cardiovascular system of the spinal rat.

1993 • 15 citations

Characteristics of precipitated withdrawal from spinal morphine: changes in [Met5]enkephalin levels

1991 • 12 citations