Ineffectiveness of Dextromethorphan in Cancer Pain

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

1994 • 368 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord

1995 • 258 citations

Cancer pain: management

1992 • 234 citations

Dextromethorphan An Overview of Safety Issues

1992 • 221 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn

1992 • 200 citations

Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design

1994 • 185 citations

Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats

1996 • 148 citations

Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance

1996 • 144 citations

Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy

1992 • 144 citations

Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats

1996 • 92 citations

An attempt to attenuate experimental pain in humans by dextromethorphan, an NMDA receptor antagonist

1995 • 52 citations

The opioid ketobemidone has a NMDA blocking effect

1996 • 31 citations