Similar 150-Kilobase DNA Sequences Are Amplified in Independently Derived Methotrexate-Resistant Chinese Hamster Cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

Preparative and analytical purification of DNA from agarose.

1979 • 1,585 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Repetitive Sequences in Eukaryotic DNA and their Expression

1982 • 575 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Mechanisms of DNA replication and recombination

1984 • 187 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Cloning of the initiation region of a mammalian chromosomal replicon

1983 • 110 citations

Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification.

1984 • 90 citations

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

1983 • 87 citations

Structure of Amplified DNA in Different Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 75 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Co-Amplification of rRNA Genes with CAD Genes in N-(Phosphonacetyl)-L-Aspartate-Resistant Syrian Hamster Cells

1983 • 54 citations

Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization

1982 • 40 citations

Organization of a Chinese Hamster Ovary Dihydrofolate Reductase Gene Identified by Phenotypic Rescue

1983 • 19 citations

Amplification of a Cloned Chinese Hamster Dihydrofolate Reductase Gene After Transfer into a Dihydrofolate Reductase-Deficient Cell Line

1983 • 18 citations

Properties of Single-Step Mutants of Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 17 citations