Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acid

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Structure and Function of the CFTR Chloride Channel

1999 • 977 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis.

1980 • 513 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis

1999 • 437 citations

Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.

1992 • 322 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Pharmacology of CFTR Chloride Channel Activity

1999 • 285 citations

Arachidonic Acid Metabolism: Implications of Biological Chemistry for Lung Function and Disease

1991 • 240 citations

Modulation of ion channels by arachidonic acid

1994 • 213 citations

Phosphorylation by Protein Kinase C Is Required For Acute Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Protein Kinase A

1997 • 204 citations

Mechanism of Glibenclamide Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Cl⁻ Channels Expressed in a Murine Cell Line

1997 • 204 citations

Volume‐regulatory Cl‐ channel currents in cultured human epithelial cells.

1992 • 185 citations

Novel pore-lining residues in CFTR that govern permeation and open-channel block

1994 • 178 citations

Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.

1994 • 160 citations

Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.

1993 • 154 citations

Adenosine Triphosphate–dependent Asymmetry of Anion Permeation in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

1998 • 148 citations

The CFTR Chloride Channel of Mammalian Heart

1995 • 140 citations

Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids.

1990 • 139 citations

Disulphonic stilbene block of cystic fibrosis transmembrane conductance regulator Cl‐ channels expressed in a mammalian cell line and its regulation by a critical pore residue.

1996 • 133 citations

Molecular pharmacology of the CFTR Cl− channel

1999 • 126 citations

Fatty acids inhibit apical membrane chloride channels in airway epithelia.

1990 • 106 citations

Multi-Ion Mechanism for Ion Permeation and Block in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

1997 • 86 citations

Flickery block of single CFTR chloride channels by intracellular anions and osmolytes

1996 • 75 citations

Non‐pore lining amino acid side chains influence anion selectivity of the human CFTR Cl⁻ channel expressed in mammalian cell lines

1998 • 73 citations

Block by MOPS reveals a conformation change in the CFTR pore produced by ATP hydrolysis

1997 • 68 citations

Modulation of K⁺ channels by arachidonic acid in T84 cells. I. Inhibition of the Ca²⁺-dependent K⁺ channel

1998 • 60 citations

Rectification of whole cell cystic fibrosis transmembrane conductance regulator chloride current

1995 • 53 citations

Structural and ionic determinants of 5‐nitro‐2‐(3‐phenylpropylamino)‐benzoic acid block of the CFTR chloride channel

1999 • 44 citations

Volume-sensitive chloride current activated by hyposmotic swelling in antral gastric myocytes of the guinea-pig

1997 • 40 citations

Substrates of multidrug resistance‐associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel

1999 • 40 citations

Involvement of arachidonic acid in the chloride secretory response of intestinal epithelial cells

1993 • 40 citations

K⁺ current inhibition by amphiphilic fatty acid metabolites in rat ventricular myocytes

1998 • 33 citations

Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids

1999 • 30 citations

Effects of arachidonic acid upon the volume‐sensitive chloride current in rat osteoblast‐like (ROS 17/2.8) cells.

1996 • 26 citations

Inhibition by fatty acids of cyclic AMP‐dependent protein kinase activity in brush border membranes isolated from human placental vesicles

1994 • 23 citations

Blockade of swelling‐induced chloride channels by phenol derivatives

1996 • 22 citations

Arylaminobenzoate Block of the Cardiac Cyclic AMP-Dependent Chloride Current

1998 • 20 citations

Arachidonic acid inhibits Cl secretion in cultures of dog tracheal epithelium

1992 • 10 citations