Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Hyperpolarizing Vasodilators Activate ATP-sensitive K ⁺ Channels in Arterial Smooth Muscle

1989 • 1,197 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL

1985 • 507 citations

Immunocytochemical localization of the cystic fibrosis gene product CFTR.

1991 • 419 citations

Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system.

1989 • 401 citations

Expression and characterization of the cystic fibrosis transmembrane conductance regulator

1990 • 340 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.

1992 • 240 citations

Structure-activity relationships of K+ channel openers

1990 • 237 citations

Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia

1992 • 225 citations

Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells

1988 • 211 citations

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

1991 • 196 citations

Bacterial periplasmic permeases belong to a family of transport proteins operating fromEscherichia colito human: Traffic ATPases

1990 • 174 citations

Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling

1991 • 157 citations

Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

1990 • 145 citations

Changes of membrane currents in cardiac cells induced by long whole-cell recordings and tolbutamide

1987 • 129 citations

Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells

1989 • 124 citations

Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle

1989 • 94 citations

Dual effects of diazoxide on ATP‐K⁺ currents recorded from an insulin‐secreting cell line

1989 • 94 citations

Cytosolic ADP enhances the sensitivity to tolbutamide of ATP‐dependent K⁺ channels from pancreatic B‐cells

1988 • 90 citations

The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4−/ADP3− and by nonhydrolyzable derivatives of both ATP and ADP

1988 • 81 citations

ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines.

1989 • 78 citations

Intestinal ion transport and diarrheal disease

1986 • 74 citations

How do sulfonylureas approach their receptor in the B-cell plasma membrane?

1989 • 60 citations

The effects of cromakalim on ATP‐sensitive potassium channels in insulin‐secreting cells

1990 • 53 citations

Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

1989 • 52 citations

Effects of pinacidil, RP 49356 and nicorandil on ATP‐sensitive potassium channels in insulin‐secreting cells

1990 • 42 citations