The Response of Gamma Interferon Activation Factor is Under Developmental Control in Cells of the Macrophage Lineage

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy

1982 • 671 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Human Leukemic Models of Myelomonocytic Development: A Review of the HL-60 and U937 Cell Lines

1985 • 649 citations

Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

1989 • 590 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.

1989 • 413 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Interferons and other regulatory cytokines

1989 • 306 citations

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

1990 • 302 citations

Interferon-activated genes

1986 • 301 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 299 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

An exonuclease protection assay reveals heat-shock element and TATA box DNA-binding proteins in crude nuclear extracts

1985 • 280 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Transcriptional induction of two genes in human cells by beta interferon.

1984 • 236 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

1989 • 218 citations

Transcriptional regulation of interferon‐stimulated genes

1991 • 184 citations

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

1991 • 178 citations

Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine.

1990 • 172 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Molecular and biochemical characterization of a novel gamma-interferon-inducible protein.

1988 • 146 citations

Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein.

1989 • 113 citations

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

1988 • 105 citations

Molecular interactions in macrophage activation

1989 • 102 citations

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

1985 • 98 citations

5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma.

1991 • 85 citations

Interferon-Dependent Signaling Pathways: DNA Elements, Transcription Factors, Mutations, and Effects of Viral Proteins

1992 • 80 citations

Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.

1988 • 77 citations

Differential regulation of a cellular gene by human interferon-gamma and interferon-alpha.

1988 • 56 citations

Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters

1992 • 51 citations

Induction of NF-KB during monocyte differentiation by HIV type 1 infection.

1991 • 46 citations

Interferon-γ Potentiates the Antiviral Activity and the Expression of Interferon-Stimulated Genes Induced by Interferon-α in U937 Cells

1992 • 45 citations

Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line.

1990 • 43 citations

Molecular Aspects of Inflammation

1991 • 42 citations

Beta and gamma interferons act synergistically to produce an antiviral state in cells resistant to both interferons individually

1989 • 35 citations

Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor.

1992 • 35 citations

Regulation of MHC class 11 gene transcription

1991 • 29 citations

Interferon‐γ regulates expression of a novel keratin classe I gene

1992 • 29 citations

Transcriptional induction of IFN-γ-responsive genes is modulated by DNA surrounding the interferon stimulation response element

1992 • 19 citations

Interaction of macrophages and cytokines

1989 • 17 citations