A bcr-v-abl Oncogene Induces Lymphomas in Transgenic Mice

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

GENE AMPLIFICATION

1984 • 580 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells.

1988 • 409 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

Unique Forms of the abl Tyrosine Kinase Distinguish Ph ¹ -Positive CML from Ph ¹ -Positive ALL

1987 • 344 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

1983 • 253 citations

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells

1986 • 236 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

1987 • 201 citations

The Chronic Myelocytic Cell Line K562 Contains a Breakpoint in bcr and Produces a Chimeric bcr/c-abl Transcript

1986 • 192 citations

Chronic myelogenous leukemia: recent advances

1985 • 190 citations

The CML-Specific P210bcr/ablProtein, Unlike v-abl, Does Not Transform NIH/3T3 Fibroblasts

1987 • 181 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

1986 • 154 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Transgenic Mice and Oncogenesis

1988 • 125 citations

Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

1988 • 118 citations

Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes

1988 • 111 citations

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

1987 • 107 citations

The intron requirement for immunoglobulin gene expression is dependent upon the promoter

1988 • 87 citations

Rapid thymomas induced by Abelson murine leukemia virus.

1982 • 83 citations

Selective Transformation of Primitive Lymphoid Cells by the BCR/ABL Oncogene Expressed in Long-Term Lymphoid or Myeloid Cultures

1988 • 80 citations

Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus.

1985 • 68 citations

Retroviral mutants efficiently expressed in embryonal carcinoma cells.

1986 • 67 citations

Comparison of myeloproliferative sarcoma virus with Moloney murine sarcoma virus variants by nucleotide sequencing and heteroduplex analysis

1984 • 45 citations

The Complexity of Virus-Cell Interactions in Abelson Virus Infection of Lymphoid and Other Hematopoietic Cells

1985 • 39 citations

Oncogenesis in Transgenic Mice

1986 • 37 citations

Expression of the c-myc Oncogene under Control of an Immunoglobulin Enhancer in Eµ-myc Transgenic Mice

1987 • 15 citations