Ketamine

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Ketamine—Its Pharmacology and Therapeutic Uses

1982 • 1,490 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

The prevention of postoperative pain

1988 • 746 citations

Ketamine: an update on the first twenty-five years of clinical experience

1989 • 714 citations

Pharmacology of Ketamine Isomers in Surgical Patients

1980 • 419 citations

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

1992 • 412 citations

RECENT ADVANCES IN THE PATHOPHYSIOLOGY OF ACUTE PAIN

1989 • 389 citations

COMPARATIVE PHARMACOLOGY OF THE KETAMINE ISOMERS

1985 • 382 citations

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

1987 • 380 citations

Psychedelic Effects of Ketamine in Healthy Volunteers

1998 • 345 citations

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1991 • 286 citations

Preemptive Effect of Fentanyl and Ketamine on Postoperative Pain and Wound Hyperalgesia

1994 • 275 citations

Ketamine Decreases Intracranial Pressure and Electroencephalographic Activity in Traumatic Brain Injury Patients during Propofol Sedation

1997 • 272 citations

Postoperative Pain

1993 • 247 citations

Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P

1994 • 246 citations

Interaction of the Chiral Forms of Ketamine with Opioid, Phencyclidine, σ and Muscarinic Receptors

1995 • 243 citations

Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro

1987 • 239 citations

Excitotoxicity, free radicals, and cell membrane changes

1994 • 228 citations

Opiate Receptor Mediation of Ketamine Analgesia

1982 • 206 citations

Is High Extracellular Glutamate the Key to Excitotoxicity in Traumatic Brain Injury?

1997 • 203 citations

Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia.

1992 • 201 citations

Mechanisms of blockade of excitatory amino acid receptor channels

1990 • 199 citations

Comparative pharmacology of the optical isomers of ketamine in mice

1978 • 192 citations

Is the Site of Action of Ketamine Anesthesia the N-Methyl-D-Aspartate Receptor?

1990 • 189 citations

Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus

1985 • 184 citations

Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice

1992 • 177 citations

Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man

1987 • 170 citations

Preemptive Ketamine Decreases Postoperative Narcotic Requirements in Patients Undergoing Abdominal Surgery

1997 • 154 citations

Inhibition of Nitric Oxide Synthase Blocks N‐Methyl‐D‐Aspartate‐, Quisqualate‐, Kainate‐, Harmaline‐, and Pentylenetetrazole‐Dependent Increases in Cerebellar Cyclic GMP In Vivo

1990 • 148 citations

Ketamine Effects on Local Cerebral Blood Flow and Metabolism in the Rat

1987 • 147 citations

Ketamine-induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice

1992 • 144 citations

Ketamine Decreases Plasma Catecholamines and Improves Outcome from Incomplete Cerebral Ischemia in Rats

1992 • 141 citations

Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury

1997 • 132 citations

Ketamine potentiates analgesic effect of morphine in postoperative epidural pain control.

1996 • 114 citations

Cerebrospinal-fluid Pressure during Dissociative Anesthesia with Ketamine

1971 • 99 citations

Cerebral Metabolic Rate and Hypothermia

1995 • 93 citations

Selective effects of ketamine on amino acid-mediated pathways in neonatal rat spinal cord

1995 • 89 citations

Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury.

1994 • 88 citations

The local monoaminergic dependency of spinal ketamine

1991 • 79 citations

Ketamine Inhibits Glutamate-, N-Methyl-D-Aspartate-, and Quisqualate-stimulated cGMP Production in Cultured Cerebral Neurons

1995 • 78 citations

The Effects of Ketamine-Isomers on Neuronal Injury and Regeneration in Rat Hippocampal Neurons

1996 • 71 citations

Non-classical glutamate receptors, blocked by both NMDA and non-NMDA antagonists, stimulate nitric oxide production in neurons

1993 • 68 citations

Intervention with Spinal NMDA, Adenosine, and NO Systems for Pain Modulation

1995 • 68 citations

Hemodynamic effects of ketamine in children undergoing cardiac catheterization

1990 • 65 citations

Ketamine Has Stereospecific Effects in the Isolated Perfused Guinea Pig Heart

1995 • 59 citations

Hypothermia-associated Protection from Ischemic Brain Injury

1996 • 49 citations

S-(+)-Ketamin und Kreislauf

1997 • 47 citations

SYSTEMIC AND CORONARY HAEMODYNAMIC EFFECTS OF KETAMINE IN INTACT ANAESTHETIZED AND UN ANAESTHETIZED DOGS

1975 • 47 citations

[Ketamine racemate or S-(+)-ketamine and midazolam. The effect on vigilance, efficacy and subjective findings].

1992 • 46 citations

Synergistic Inhibition of Muscarinic Signaling by Ketamine Stereoisomers and the Preservative Benzethonium Chloride

1997 • 46 citations

[The action of S-(+)-ketamine on serum catecholamine and cortisol. A comparison with ketamine racemate].

1992 • 43 citations

Neuroprotektion durch Ketamin auf zellulärer Ebene

1997 • 43 citations

The cardiovascular effects of ketamine in man

1976 • 42 citations

Ketamine inhibition of ligand binding to cholinergic receptors and ion channels

1982 • 38 citations

Inhibition by Ketamine of Muscarinic Acetylcholine Receptor Function

1995 • 37 citations

Anesthetic effects on 5-hydroxytryptamine uptake by rat brain synaptosomes

1988 • 36 citations

Halothane anaesthesia reverses the neuroprotective effect of ketamine against ibotenic acid toxicity in the rat hippocampus

1989 • 23 citations

Klinischer Stellenwert des S-(+)-Ketamin

1997 • 21 citations

Ketamine inhibition of cytoplasmic calcium signalling in rat pheochromocytoma (PC-12) cells

1993 • 21 citations

Cardiac transplantation: A prospective comparison of ketamine and sufentanil for anesthetic induction

1989 • 20 citations

Ketamine promotes hippocampal CA1 pyramidal neuron loss after a short-duration ischemic insult in rats

1991 • 19 citations

EFFECTS OF VOLATILE ANAESTHETICS ON SECOND MESSENGER Ca 2+ IN NEURONES AND NON-MUSCULAR CELLS

1993 • 18 citations

[Cerebral neuroprotection and ketamine].

1994 • 17 citations

[Actions of ketamine not related to NMDA and opiate receptors].

1994 • 16 citations

Nonstereospecific Actions of Ketamine Isomers on the Force of Contraction, Spontaneous Beating Rate, and Ca2+ Current in the Guinea Pig Heart

1996 • 16 citations

[Animal experiment study on intracranial pressure, after ketamine administration].

1984 • 14 citations

Neuroprotection: fact or fantasy?

1995 • 9 citations

On the mechanism of the interaction of ketamine and halothane in vitro

1992 • 8 citations