Control of Fibrosis in Systemic Scleroderma.

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

Integrins.

1991 • 1,369 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Fibronectin: current concepts of its structure and functions

1980 • 735 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Fibronectins

1990 • 523 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Transforming growth factor-β regulates production of proteoglycans by mesangial cells

1990 • 365 citations

Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils.

1991 • 354 citations

Domains of laminin with growth-factor activity

1989 • 341 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma

1979 • 331 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Regulation of collagen synthesis in fibroblasts within a three-dimensional collagen gel

1988 • 255 citations

The cellular interactions of laminin fragments. Cell adhesion correlates with two fragment-specific high affinity binding sites.

1987 • 243 citations

Scleroderma

1979 • 241 citations

Collagen Biosynthesis by Cells in a Tissue Equivalent Matrix In Vitro

1984 • 233 citations

Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.

1990 • 219 citations

Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness

1989 • 216 citations

Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization

1988 • 207 citations

Attachment of cells to basement membrane collagen type IV.

1986 • 198 citations

Systemic scleroderma

1988 • 187 citations

Identification of Fibroblasts Responsible for Increased Collagen Production in Localized Scleroderma by In Situ Hybridization

1988 • 176 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Immunohistologic Demonstration of Platelet-derived Growth Factor (PDGF) and sis-Oncogene Expression in Scleroderma

1989 • 173 citations

Fibroblast selection in scleroderma

1982 • 168 citations

Evaluation of Transforming Growth Factor β and Type I Procollagen Gene Expression in Fibrotic Skin Disease by In Situ Hybridization

1990 • 155 citations

Transforming Growth Factor-Beta: Selective Increase in Glycosaminoglycan Synthesis by Cultures of Fibroblasts From Patients With Progressive Systemic Sclerosis

1987 • 145 citations

Immunogenetic associations of scleroderma‐related antinuclear antibodies

1990 • 145 citations

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

1989 • 136 citations

A STRATEGY FOR DETERMINING THE PATHOGENESIS OF SYSTEMIC SCLEROSIS: Is Transforming Growth Factor β the Answer?

1989 • 134 citations

The genetically distinct collagens

1985 • 124 citations

Identification of Collagen Fibrils in Scleroderma Skin

1988 • 119 citations

Scleroderma and the Subcutaneous Tissue

1971 • 116 citations

Collagen in the cellular and fibrotic stages of scleroderma

1978 • 114 citations

Glycosaminoglycans in Scleroderma and Scleredema

1972 • 114 citations

Protocollagen Proline Hydroxylase Activity in the Skin of Normal Human Subjects and of Patients with Scleroderma

1969 • 103 citations

Fibroblast-Matrix Interactions and Their Role in the Pathogenesis of Fibrosis

1990 • 89 citations

Aminoterminal extension peptides from type I procollagen normalize excessive collagen synthesis of scleroderma fibroblasts

1978 • 82 citations

Synergistic effect of tumor necrosis factor-α and interferon-γ on collagen synthesis of human skin fibroblasts in vitro

1989 • 77 citations

THE PATHOPHYSIOLOGY OF SCLERODERMA

1977 • 75 citations

Serum and Urine Analysis of the Aminoterminal Procollagen Peptide Type III by Radioimmunoassay with Antibody Fab Fragments

1983 • 72 citations

HLA ANTIGENS, AUTOANTIBODIES AND CLINICAL SUBSETS IN SCLERODERMA

1984 • 66 citations

Transforming growth factor-β1 induces extracellular matrix formation in glomerulonephritis

1990 • 65 citations

Inhibition of fibroblast chemotaxis by recombinant human interferon γ and interferon α

1987 • 62 citations

Collagen Synthesis by Scleroderma Fibroblastsa

1985 • 51 citations

Down‐regulation of α3(VI) chain expression by γ‐interferon decreases synthesis and deposition of collagen type VI

1989 • 50 citations

Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures

1985 • 43 citations

Fibroblast Chemotaxis

1985 • 43 citations

Collagen Fibrils of the Scleroderma in Ultra-thin Skin Sections

1964 • 41 citations

Activation of type I collagen genes in cultured scleroderma fibroblasts

1985 • 40 citations

SERUM TYPE III PROCOLLAGEN PEPTIDE CONCENTRATIONS IN SYSTEMIC SCLEROSIS AND RAYNAUD'S PHENOMENON: RELATIONSHIP TO DISEASE ACTIVITY AND DURATION

1989 • 39 citations

Genetic Factors in Scleroderma

1990 • 32 citations

Connective tissue in scleroderma. A biochemical study on the correlation of fractionated glycosaminoglycans and collagen in human skin

1971 • 28 citations

Collagen synthesis regulation by the aminopropeptide of procollagen i in normal and scleroderma fibroblasts

1985 • 21 citations

A fibroblast mitogen present in scleroderma but not control sera: Inhibition by proteinase inhibitors

1983 • 18 citations

Serum levels of type III collagen aminopropeptide in patients with systemic scleroderma

1987 • 17 citations

Type III collagen aminopropeptide and laminin PI levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma

1990 • 17 citations