Systemic scleroderma

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Interleukin 1, a potential regulator of fibroblast proliferation.

1982 • 835 citations

Autoantibody to centromere (kinetochore) in scleroderma sera.

1980 • 721 citations

Normal and abnormal aspects of proteinuria

1986 • 536 citations

Systemic Scleroderma

1961 • 536 citations

Diversity of antinuclear antibodies in progressive systemic sclerosis

1980 • 520 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

1981 • 430 citations

[10] Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

1982 • 406 citations

Pulmonary hypertension in the crest syndrome variant of systemic sclerosis

1986 • 377 citations

The CREST syndrome: A distinct serologic entity with anticentromere antibodies

1980 • 369 citations

Lymphocyte-Mediated Activation of Fibroblast Proliferation and Collagen Production

1978 • 358 citations

Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma

1979 • 331 citations

Survival with Systemic Sclerosis (Scleroderma)

1971 • 327 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

<scp>D</scp>-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma)

1982 • 317 citations

Kinetochore structure, duplication, and distribution in mammalian cells: analysis by human autoantibodies from scleroderma patients.

1981 • 312 citations

Evidence for Chronic Inflammation as a Component of the Interstitial Lung Disease Associated with Progressive Systemic Sclerosis

1985 • 310 citations

High Titers of Autoantibodies to Topoisomerase I (Scl-70) in Sera from Scleroderma Patients

1986 • 307 citations

Endothelial injury in scleroderma.

1979 • 289 citations

Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

1985 • 282 citations

Epidemiology of Systemic Sclerosis (Scleroderma)

1971 • 279 citations

Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma.

1979 • 279 citations

Human Skin Fibroblasts Derived from Papillary and Reticular Dermis: Differences in Growth Potential in Vitro

1979 • 276 citations

PULMONARY INSUFFICIENCY III. A STUDY OF 122 CASES OF CHRONIC PULMONARY EMPHYSEMA

1949 • 266 citations

Controlled Double-Blind Trial of Nifedipine in the Treatment of Raynaud's Phenomenon

1983 • 245 citations

Xeroderma Pigmentosum: Variants with Normal Dna Repair and Normal Sensitivity to Ultraviolet Light

1972 • 244 citations

Physiologic Abnormalities of Cardiac Function in Progressive Systemic Sclerosis with Diffuse Scleroderma

1984 • 243 citations

Autoantibody to RNA polymerase I in scleroderma sera.

1987 • 241 citations

Scleroderma

1979 • 241 citations

Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis

1984 • 232 citations

The gastrointestinal manifestations of scleroderma: Pathogenesis and management

1980 • 230 citations

Hypertension and Renal Failure (Scleroderma Renal Crisis) in Progressive Systemic Sclerosis

1983 • 229 citations

Reversal of Vascular and Renal Crises of Scleroderma by Oral Angiotensin-Converting-Enzyme Blockade

1979 • 210 citations

Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies.

1986 • 206 citations

Variability in Collagen and Fibronectin Synthesis by Scleroderma Fibroblasts in Primary Culture

1981 • 201 citations

Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.

1982 • 201 citations

Antinuclear antibody with distinct specificity for polymyositis.

1977 • 198 citations

INTERMITTENT EPOPROSTENOL (PROSTACYCLIN) INFUSION IN PATIENTS WITH RAYNAUD'S SYNDROME

1983 • 181 citations

Detection of a nucleolar 7-2 ribonucleoprotein and a cytoplasmic 8-2 ribonucleoprotein with autoantibodies from patients with scleroderma.

1983 • 177 citations

Pulmonary involvement in systemic sclerosis (scleroderma)

1985 • 168 citations

Fibroblast selection in scleroderma

1982 • 168 citations

Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma).

1978 • 154 citations

The articular manifestations of progressive systemic sclerosis (scleroderma).

1982 • 149 citations

MULTIPLE TELANGIECTASIA, RAYNAUD'S PHENOMENON, SCLERODACTYLY, AND SUBCUTANIOUS CALCINOSIS: A SYNDROME MIMICKING HEREDITARY HEMORRHAGIC TELANGIECTASIA.

1964 • 146 citations

Scleroderma and pseudoscleroderma

1976 • 144 citations

Inhibition of collagen synthesis by mononuclear cell supernates.

1979 • 142 citations

The 2‐oxoglutarate binding site of prolyl 4‐hydroxylase

1984 • 139 citations

Rheumatic disorders in primary biliary cirrhosis.

1978 • 138 citations

Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I

1986 • 133 citations

Anticentromere and Anticentriole Antibodies in the Scleroderma Spectrum

1983 • 133 citations

Skeletal muscle involvement in progressive systemic sclerosis (scleroderma)

1968 • 130 citations

Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes.

1986 • 124 citations

The genetically distinct collagens

1985 • 124 citations

Human anticentromere antibodies: Distribution, characterization of antigens, and effect on microtubule organization

1983 • 120 citations

Decreased coronary reserve in primary scleroderma myocardial disease

1985 • 117 citations

Scleroderma and the Subcutaneous Tissue

1971 • 116 citations

Glycosaminoglycans in Scleroderma and Scleredema

1972 • 114 citations

Collagen in the cellular and fibrotic stages of scleroderma

1978 • 114 citations

Sjögren's syndrome in progressive systemic sclerosis (scleroderma)

1974 • 112 citations

Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon.

1982 • 111 citations

The electrocardiogram in systemic sclerosis (scleroderma). Study of 102 consecutive cases with functional correlations and review of the literature

1985 • 105 citations

Immunofluorescence Analysis of Collagen, Fibronectin, and Basement Membrane Protein in Scleroderma Skin

1980 • 103 citations

Antibodies to collagen in scleroderma

1982 • 103 citations

Protocollagen Proline Hydroxylase Activity in the Skin of Normal Human Subjects and of Patients with Scleroderma

1969 • 103 citations

An Historical Account of the Study of Progressive Systemic Sclerosis (Diffuse Scleroderma)

1962 • 103 citations

Classification and Nomenclature of Progressive Systemic Sclerosis (Scleroderma)

1979 • 102 citations

The Kidney in Progressive Systemic Sclerosis

1978 • 98 citations

Lung Involvement in Scleroderma

1984 • 98 citations

Anticentromere antibodies in primary biliary cirrhosis

1983 • 97 citations

Long-term evaluation of colchicine in the treatment of scleroderma.

1979 • 95 citations

The Nature of Joint Involvement in Progressive Systemic Sclerosis (Diffuse Scleroderma)

1962 • 91 citations

Scleroderma and pseudoscleroderma

1975 • 88 citations

INCREASED FREQUENCY OF HLA–DR5 IN SCLERODERMA

1981 • 86 citations

The relationship of arrhythmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis (PSS)

1981 • 84 citations

Regulation of protein synthesis: translational control by procollagen-derived fragments.

1981 • 84 citations

Renal involvement in progressive systemic sclerosis (generalized scleroderma)

1957 • 83 citations

Comparative Esophageal and Anorectal Motility in Scleroderma

1985 • 83 citations

Treatment of Raynaud's phenomenon with the 5-HT2-receptor antagonist ketanserin.

1982 • 82 citations

Aminoterminal extension peptides from type I procollagen normalize excessive collagen synthesis of scleroderma fibroblasts

1978 • 82 citations

Systemic Sclerosis (Scleroderma).

1985 • 80 citations

Skin Capillary Changes in Early Systemic Scleroderma

1976 • 80 citations

Antinucleolar Antibodies in Human Sera

1973 • 76 citations

Synthesis of Types I, III and AB2 Collagen by Chick Tendon Fibroblasts in vitro

1980 • 72 citations

Increased Protocollagen Proline Hydroxylase Activity in Sclerodermatous Skin

1971 • 70 citations

Cytotoxicity of sera from patients with scleroderma

1983 • 70 citations

Endothelial injury in scleroderma. A protease mechanism.

1983 • 70 citations

The 'CREST' syndrome. Comparison with systemic sclerosis (scleroderma)

1979 • 69 citations

Systemic sclerosis (scleroderma) and esophageal adenocarcinoma: Is increased patient screening necessary?

1985 • 67 citations

Increased frequency of B8/DR3 in scleroderma and association of the haplotype with impaired cellular immune response.

1981 • 67 citations

HLA ANTIGENS, AUTOANTIBODIES AND CLINICAL SUBSETS IN SCLERODERMA

1984 • 66 citations

Suppressor cell function and t lymphocyte subpopulations in peripheral blood of patients with progressive systemic sclerosis

1983 • 64 citations

Clinical and serologic study of sjögren's syndrome in patients with progressive systemic sclerosis

1983 • 64 citations

Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)

1982 • 63 citations

Chronic disease of the liver associated with systemic scleroderma

1964 • 62 citations

Primary heart disease in systemic sclerosis (scleroderma): Advances in clinical and pathologic features, pathogenesis, and new therapeutic approaches

1981 • 60 citations

Type III Collagen Aminopropeptide Levels in Serum of Patients With Progressive Systemic Scleroderma

1986 • 59 citations

Soluble mediators from mononuclear cells increase the synthesis of glycosaminoglycan by dermal fibroblast cultures derived from normal subjects and progressive systemic sclerosis patients

1985 • 58 citations

Abnormalities of T lymphocyte subsets in patients with progressive systemic sclerosis (PSS, scleroderma).

1981 • 58 citations

Manometric assessment of oesophageal involvement in progressive systemic sclerosis, morphoea and Raynaud's disease

1982 • 58 citations

Pathogenesis and staging of scleroderma

1975 • 56 citations

The Connective Tissue in Scleroderma

1981 • 56 citations

Small airways in progressive systemic sclerosis (PSS)

1979 • 56 citations

Scleroderma: Progressive Systemic Sclerosis

1975 • 54 citations

The'CREST'Syndrome

1979 • 54 citations

Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors.

1982 • 53 citations

Collagen Synthesis by Scleroderma Fibroblastsa

1985 • 51 citations

Pathogenesis and staging of scleroderma.

1976 • 51 citations

Immunoregulatory T cell subpopulations in patients with scleroderma using monoclonal antibodies.

1982 • 51 citations

Gastrointestinal Telangiectasia as a Cause of Severe Blood Loss in Systemic Sclerosis

1980 • 50 citations

Increased Procollagen mRNA Levels in Scleroderma Skin Fibroblasts

1983 • 49 citations

Collagen Biosynthesis in Systemic Scleroderma: Regulation of Posttranslational Modifications and Synthesis of Procollagen in Cultured Fibroblasts

1985 • 47 citations

Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures

1985 • 43 citations

Cytotoxic activity of sera from scleroderma and other connective tissue diseases. lack of cellular and disease specificity

1982 • 41 citations

Collagen Fibrils of the Scleroderma in Ultra-thin Skin Sections

1964 • 41 citations

Lymphokine/Monokine Inhibition of Fibroblast Proliferation and Collagen Production: Role in Progressive Systemic Sclerosis (PSS)

1984 • 41 citations

Activation of type I collagen genes in cultured scleroderma fibroblasts

1985 • 40 citations

Steatorrhoea in Progressive Systemic Sclerosis (Scleroderma)

1962 • 39 citations

Collagen and elastin changes in d-penicillamine-induced pseudoxanthoma elasticum-like skin

1986 • 37 citations

The kidney in progressive systemic sclerosis: immunohistochemical and antibody elution studies.

1976 • 37 citations

Products of activated mononuclear cells modulate accumulation of collagen by normal dermal and scleroderma fibroblasts in culture.

1984 • 35 citations

Cyclofenil versus Placebo in Progressive Systemic Sclerosis

1981 • 34 citations

Anticentromere antibody: an immunological marker of a subset of systemic sclerosis

1985 • 34 citations

Connective tissue : biological and clinical aspects

1986 • 34 citations

Cyclofenil versus placebo in progressive systemic sclerosis. A one-year double-blind crossover study of 27 patients.

1981 • 33 citations

Zentromerantikörper und Antikörper gegen Scl-70-Nucleoprotein bei progressiver systemischer Sklerodermie: Diagnostische und prognostische Bedeutung

2008 • 33 citations

Small intestinal bacterial growth in systemic sclerosis

1980 • 32 citations

Scleroderma of the lungs.

1959 • 32 citations

Scleroderma (Progressive Systemic Sclerosis).

1974 • 32 citations

The visceral manifestations of scleroderma

1962 • 31 citations

Idiopathic portal hypertension associated with progressive systemic sclerosis.

1982 • 31 citations

The arthropathy of systemic sclerosis (scleroderma); comparison with mixed connective tissue disease.

1983 • 30 citations

Jaccoud's arthropathy in scleroderma.

1984 • 30 citations

Lymphocyte subpopulations and reactivity to mitogens in patients with scleroderma.

1981 • 29 citations

Bleeding gastric telangiectasia. Complication of Raynaud's phenomenon, esophageal motor dysfunction, sclerodactyly and telangiectasia (REST) syndrome.

1981 • 28 citations

Radionuclide esophageal transit in progressive systemic sclerosis.

1985 • 28 citations

RENAL INVOLVEMENT IN PROGRESSIVE SYSTEMIC SCLEROSIS (SCLERODERMA)

1960 • 28 citations

THE EFFECT OF INTERMITTENT LOW MOLECULAR DEXTRAN INFUSIONS UPON THE DIGITAL CIRCULATION IN SYSTEMIC SCLEROSIS.

1965 • 28 citations

Collagen Fibrillogenesis: A Mechanism of Structural Biology

1986 • 27 citations

Electromyographic findings in various forms of progressive systemic sclerosis

1982 • 26 citations

Assessment of esophageal abnormalities in progressive systemic sclerosis using radionuclide transit.

1985 • 25 citations

[Clinical aspects of progressive systemic scleroderma (PSS). Multicenter studies of 194 patients].

1986 • 22 citations

Collagen synthesis regulation by the aminopropeptide of procollagen i in normal and scleroderma fibroblasts

1985 • 21 citations

DR antigens in systemic sclerosis: lack of clinical correlations

1985 • 21 citations

The Heart in Scleroderma: Noninvasive assessment

1982 • 20 citations

Early changes in oesophageal function in progressive systemic sclerosis: a comparison of manometry and radiology

1984 • 20 citations

Autologous and allogeneic mixed lymphocyte reactions in progressive systemic sclerosis

1982 • 19 citations

Enhanced platelet adhesion to collagen in scleroderma. Effect of scleroderma plasma and scleroderma platelets.

1985 • 19 citations

Dermatologie und Rheuma

1987 • 18 citations

A fibroblast mitogen present in scleroderma but not control sera: Inhibition by proteinase inhibitors

1983 • 18 citations

Barrett's esophagus complicating scleroderma

1985 • 16 citations

[Generalized scleroderma and chromosome breakage. Demonstration of a breaking factor in patients serum].

1973 • 14 citations

Treatment of Generalized Scleroderma with Inhibitors of Collagen Synthesis

1982 • 13 citations

The joint manifestations of the connective tissue diseases

1982 • 12 citations

Immunohistochemical demonstration of proteoglycans in the skin of patients with systemic sclerosis

1983 • 12 citations

Surface proteins of scleroderma fibroblasts in culture.

1984 • 10 citations

Einteilung und Klinik der progressiven systemischen Sklerodermie

1987 • 7 citations