A Human Alloantibody Interferes With Binding of Factor IXa to the Factor VIII Light Chain

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

1993 • 482 citations

Hemophilia A

1994 • 348 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 316 citations

Association of the factor VIII light chain with von Willebrand factor.

1988 • 223 citations

A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine

1993 • 199 citations

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1994 • 192 citations

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

1989 • 183 citations

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

1995 • 181 citations

Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition

1996 • 175 citations

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII.

1994 • 175 citations

A Multicenter Study of Recombinant Factor VIII (Recombinate): Safety, Efficacy, and Inhibitor Risk in Previously Untreated Patients With Hemophilia A

1994 • 162 citations

The Sequence Glu1811-Lys1818 of Human Blood Coagulation Factor VIII Comprises a Binding Site for Activated Factor IX

1996 • 159 citations

The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII

1989 • 149 citations

Detection of the Carrier State in Hereditary Coagulation Disorders I

1968 • 148 citations

Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments.

1985 • 144 citations

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1995 • 137 citations

Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization

1989 • 130 citations

Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.

1988 • 122 citations

Factor VIII Inhibitor Antibodies with C2 Domain Specificity Are Less inhibitory to Factor VIII Complexed with von Willebrand Factor

1996 • 96 citations

The Missense Mutation Arg593 → Cys Is Related to Antibody Formation in a Patient With Mild Hemophilia A

1997 • 83 citations

Inhibition of human factor VIIIa by anti-A2 subunit antibodies.

1994 • 83 citations

Incidence of Factor VIII Inhibitor Development in Hemophilia A Patients Treated with Less Pure Plasma Derived Concentrates

1994 • 69 citations

Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments

1989 • 65 citations

A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human inhibitor antibodies that bind to A2

1993 • 62 citations

A Soluble Recombinant Factor VIII Fragment Containing the A2 Domain Binds to Some Human Anti-Factor VIII Antibodies that Are not Detected by Immunoblotting

1992 • 51 citations

Biological activity of recombinant factor VIII variants lacking the central B‐domain and the heavy‐chain sequence Lys⁷¹³‐Arg⁷⁴⁰: discordant in vitro and in vivo activity

1993 • 30 citations