The Missense Mutation Arg593 → Cys Is Related to Antibody Formation in a Patient With Mild Hemophilia A

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

1992 • 613 citations

Acquired inhibitors of blood coagulation.

1972 • 531 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 498 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

1993 • 482 citations

Hemophilia A

1994 • 348 citations

Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation

1995 • 336 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 316 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A

1993 • 183 citations

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

1995 • 181 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 171 citations

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition

1994 • 156 citations

Detection of the Carrier State in Hereditary Coagulation Disorders I

1968 • 148 citations

Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments.

1985 • 144 citations

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1995 • 137 citations

Prevalence of Inhibitors in a Population of 3435 Hemophilia Patients in France

1992 • 135 citations

Molecular etiology of factor VIII deficiency in hemophilia A

1995 • 131 citations

Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization

1989 • 130 citations

Circulating anticoagulants to factor VIII

1970 • 130 citations

Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.

1988 • 122 citations

Acquired Circulating Anticoagulants in Hemophilia A

1969 • 108 citations

Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A)

1995 • 71 citations

Incidence of Factor VIII Inhibitor Development in Hemophilia A Patients Treated with Less Pure Plasma Derived Concentrates

1994 • 69 citations

Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments

1989 • 65 citations

Inhibitors to Factor VIII in a Family with Mild Hemophilia: Molecular Characterization and Response to Factor VIII and Desmopressin

1995 • 55 citations

A Soluble Recombinant Factor VIII Fragment Containing the A2 Domain Binds to Some Human Anti-Factor VIII Antibodies that Are not Detected by Immunoblotting

1992 • 51 citations

Immunoblot analysis shows changes in factor VIII inhibitor chain specificity in factor VIII inhibitor patients over time

1988 • 47 citations

Acquired factor VIII inhibitor associated with chronic interferon‐alpha therapy in a patient with haemophilia A

1994 • 46 citations

Screening for mutations in haemophilia A patients by multiplex PCR‐SSCP, Southern blotting and RNA analysis: the detection of a genetic abnormality in the factor VIII gene in 30 out of 35 patients

1995 • 43 citations

WHY DO SO MANY HAEMOPHILIA A PATIENTS DEVELOP AN INHIBITOR?

1995 • 38 citations

Biological activity of recombinant factor VIII variants lacking the central B‐domain and the heavy‐chain sequence Lys⁷¹³‐Arg⁷⁴⁰: discordant in vitro and in vivo activity

1993 • 30 citations

Inhibitor of Factor VIII in Mild Haemophilia

1969 • 30 citations

Inhibitor to Factor VIII in Mild Haemophilia

1984 • 29 citations

Acute myocardial infarction complicating prothrombin complex concentrate therapy in an 8-year-old boy with hemophilia A and factor VIII inhibitor.

1993 • 24 citations

Factor VIII antibody in a patient with mild haemophilia

1985 • 19 citations

Successful treatment with prothrombin complex concentrate of postoperative bleeding in a haemophiliac with a factor VIII inhibitor.

1976 • 19 citations

A Factor VIII Inhibitor in a Mild Hemophiliac

1970 • 14 citations

Molecular etiology of factor VIII deficiency in hemophilia A

1995 • 11 citations

Factor VIII Inhibitor in a Patient with Mild Hemophilia A

1972 • 11 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 7 citations

Frequency of inhibitors in haemophiliacs

1992 • 6 citations

Deleted Work

1955 • 0 citations