Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATION

1974 • 2,413 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

Human Plasma Protein C

1979 • 511 citations

[Changes under the influence of high pressure of certain properties of myosin, actomyosin and actin].

1960 • 499 citations

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

1988 • 405 citations

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1986 • 404 citations

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.

1988 • 385 citations

The molecular basis of blood diseases

1988 • 341 citations

Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor.

1991 • 275 citations

Association of the factor VIII light chain with von Willebrand factor.

1988 • 223 citations

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1991 • 217 citations

Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine

1990 • 198 citations

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity.

1991 • 189 citations

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

1989 • 183 citations

In vivo significance of kinetic constants of protein proteinase inhibitors

1984 • 150 citations

The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII

1989 • 149 citations

Subunit structure of thrombin-activated porcine factor VIII

1989 • 147 citations

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies

1985 • 142 citations

Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma.

1986 • 140 citations

Loss of prothrombin and of factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C.

1984 • 133 citations

von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation

1991 • 125 citations

Inactivation of factor VIII by activated protein C and protein S

1987 • 121 citations

Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid

1984 • 117 citations

Activation of porcine factor VIII:C by thrombin and factor Xa

1985 • 114 citations

Interaction of factor VIII-von Willebrand Factor with phospholipid vesicles

1981 • 104 citations

Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.

1983 • 94 citations

Identification of the binding site for activated protein C on the light chain of factors V and VIII.

1990 • 88 citations

Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles.

1992 • 87 citations

The Role of Factor VIII in the Activation of Human Blood Coagulation Factor X by Activated Factor IX

1985 • 77 citations

Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments

1989 • 65 citations

The association of coagulation factor Xa and factor Va

1991 • 61 citations

Binding of human blood-coagulation Factors IXa and X to phospholipid membranes

1984 • 60 citations

Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa

1992 • 58 citations

Inactivation of factor VIII by factor IXa

1992 • 50 citations

Epitope mapping of functional domains of human factor Va with human and murine monoclonal antibodies. Evidence for the interaction of heavy chain with factor Xa and calcium

1987 • 47 citations

Activation of Human Coagulation Factor VIII by Activated Factor X, the Common Product of the Intrinsic and the Extrinsic Pathway of Blood Coagulation

1982 • 47 citations

Factor IXa enhances reconstitution of factor VIIIa from isolated A2 subunit and A1/A3-C1-C2 dimer.

1992 • 46 citations

The pro-polypeptide of von Willebrand factor is required for the formation of a functional factor VIII-binding site on mature von Willebrand factor

1991 • 33 citations

Inactivation of human factor VIII by activated protein C: evidence that the factor VIII light chain contains the activated protein C binding site

1989 • 32 citations

A Rapid One-Step Immunoradiometric Assay for Factor VIII-Procoagulant Antigen Utilizing Monoclonal Antibodies

1983 • 19 citations

Application of sepharose-linked monoclonal antibodies for the immunoradiometric measurement of factor VIII-procoagulant antigen

1984 • 18 citations

Factor IXa protects activated factor VIII against inactivation by activated protein C

1984 • 18 citations