Intracellular proteolysis

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Hsp90 as a capacitor for morphological evolution

1998 • 2,261 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Evolvability

1998 • 1,051 citations

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

1997 • 806 citations

Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis

1999 • 801 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1978 • 622 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

The mechanism and functions of ATP‐dependent proteases in bacterial and animal cells

1992 • 450 citations

How the Cyclin Became a Cyclin

1999 • 441 citations

The degradation signal in a short-lived protein

1989 • 427 citations

Ubiquitin, cellular inclusions and their role in neurodegeneration

1998 • 396 citations

Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes.

1980 • 393 citations

Viewpoint: Putting the Cell Cycle in Order

1996 • 357 citations

Turnover of protein in growing and non-growing populations of Escherichia coli

1958 • 309 citations

Degradation of Abnormal Proteins in Escherichia coli

1972 • 298 citations

The Dynamic State of Body Constituents

1942 • 266 citations

ATP-dependent degradation of ubiquitin-protein conjugates.

1984 • 248 citations

Studies on the induced synthesis of β-galactosidase in Escherichia coli: The kinetics and mechanism of sulfur incorporation

1955 • 243 citations

Proteolytic ratchets that control progression through mitosis

1998 • 122 citations

Separating sister chromatids

1999 • 119 citations

Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.

1997 • 90 citations