ATR1, a Saccharomyces cerevisiae Gene Encoding a Transmembrane Protein Required for Aminotriazole Resistance

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Complete Nucleotide Sequence of the Escherichia coli Plasmid pBR322

1979 • 1,807 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

The molecular biology of the yeast saccharomyces: Metabolism and gene expression

1983 • 1,118 citations

Transformation in yeast: Development of a hybrid cloning vector and isolation of the can1 gene

1979 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments

1979 • 967 citations

Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.

1980 • 584 citations

Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene

1980 • 511 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

Evidence for translational regulation of the activator of general amino acid control in yeast.

1984 • 472 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences.

1986 • 320 citations

Nucleotide sequence and transcriptional mapping of the yeastpet56-his3-dedlgene region

1985 • 290 citations

Positive regulation in the general amino acid control of Saccharomyces cerevisiae.

1983 • 279 citations

5' untranslated sequences are required for the translational control of a yeast regulatory gene.

1984 • 257 citations

Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae

1975 • 252 citations

Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli.

1979 • 247 citations

A systematic DNA sequencing strategy

1982 • 213 citations

Inducible plasmid-determined resistance to arsenate, arsenite, and antimony (III) in escherichia coli and Staphylococcus aureus

1981 • 212 citations

Energy-dependent efflux of cadmium coded by a plasmid resistance determinant in Staphylococcus aureus

1981 • 184 citations

THE CAN1 LOCUS OF SACCHAROMYCES CEREVISIAE: FINE-STRUCTURE ANALYSIS AND FORWARD MUTATION RATES

1979 • 158 citations

Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3).

1977 • 147 citations

Transcription of the his3 gene region in Saccharomyces cerevisiae

1981 • 145 citations

The basis of multidrug resistance in mammalian cells: Homology with bacterial transport

1986 • 134 citations

Regulation of Compartmentation of Amino Acid Pools in Saccharomyces cerevisiae and Its Effects on Metabolic Control

1980 • 123 citations

The General Control of Amino Acid Biosynthetic Genes in the Yeast Saccharomyces Cerevisia

1986 • 112 citations

Synergism of aminotriazole and phosphate on the inhibition of yeast imidazole glycerol phosphate dehydratase

1965 • 111 citations

Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast.

1983 • 101 citations

Direct selection for gene replacement events in yeast

1983 • 86 citations

ALLELISM OF PLEIOTROPIC DRUG RESISTANCE INSACCHAROMYCES CEREVISIAE

1982 • 44 citations

Ion Extrusion Systems in Bacteria

1985 • 12 citations