Metabolic engineering

Toward a Science of Metabolic Engineering

1991 • 1,137 citations

Network Rigidity and Metabolic Engineering in Metabolite Overproduction

1991 • 577 citations

Metabolic control theory: A structural approach

1988 • 560 citations

Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction

1993 • 514 citations

Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the ‘top‐down’ approach of metabolic control theory

1990 • 267 citations

A ‘top‐down’ approach to the determination of control coefficients in metabolic control theory

1990 • 209 citations

Responses of metabolic systems to large changes in enzyme activities and effectors

1993 • 160 citations

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

1992 • 160 citations

Responses of metabolic systems to large changes in enzyme activities and effectors

1993 • 83 citations

Experimental application of top-down control analysis to metabolic systems

1993 • 71 citations

Determination of Flux Control Coefficients from transient metabolite concentrations

1992 • 62 citations

Metabolic control analysis using transient metabolite concentrations. Determination of metabolite concentration control coefficients

1992 • 38 citations

Synthesis of biochemical production routes

1992 • 33 citations

Experimental determination of flux control distribution in biochemical systems: In vitro model to analyze transient metabolite concentrations

1993 • 27 citations