Responses of metabolic systems to large changes in enzyme activities and effectors

Data Reduction and Error Analysis for the Physical Sciences

1969 • 13,865 citations

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

1974 • 1,378 citations

THE MOLECULAR BASIS OF DOMINANCE

1981 • 1,033 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Molecular Democracy: Who Shares the Controls?

1979 • 454 citations

An anti-sense chalcone synthase gene in transgenic plants inhibits flower pigmentation

1988 • 436 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

Decreased ribulose-1,5-bisphosphate carboxylase-oxygenase in transgenic tobacco transformed with ?antisense? rbcS

1991 • 300 citations

Overproduction of glycolytic enzymes in yeast

1989 • 295 citations

Control of Metabolic Processes

1990 • 290 citations

Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the ‘top‐down’ approach of metabolic control theory

1990 • 267 citations

Metabolic Flux and Fitness

1987 • 245 citations

Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae

1990 • 243 citations

The function of the Waxy locus in starch synthesis in maize endosperm

1974 • 217 citations

A ‘top‐down’ approach to the determination of control coefficients in metabolic control theory

1990 • 209 citations

Metabolic compartmentation

1983 • 205 citations

Control of metabolism: What do we have to measure?

1987 • 191 citations

Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway

1978 • 189 citations

Metabolic control theory: its role in microbiology and biotechnology

1986 • 186 citations

Control analysis of photosynthate partitioning

1990 • 179 citations

Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon

1986 • 175 citations

The control of enzyme systems in vivo: Elasticity analysis of the steady state

1983 • 170 citations

Sensitivity amplification in biochemical systems

1982 • 165 citations

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

1992 • 160 citations

Control of the Lysine Biosynthesis Sequence in Corynebacterium glutamicum as Analyzed by Overexpression of the Individual Corresponding Genes

1991 • 154 citations

Decreased-activity mutants of phosphoglucose isomerase in the cytosol and chloroplast of Clarkia xantiana. Impact on mass-action ratios and fluxes to sucrose and starch, and estimation of Flux Control Coefficients and Elasticity Coefficients

1989 • 149 citations

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

1986 • 142 citations

Quantification of the importance of individual steps in the control of aromatic amino acid metabolism

1986 • 141 citations

Characterization of rate-controlling steps in vivo by use of an adjustable expression vector.

1985 • 129 citations

Reduced-activity mutants of phosphoglucose isomerase in the cytosol and chloroplast of Clarkia xantiana

1989 • 121 citations

Control of the flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration

1981 • 117 citations

ENZYME VARIATION, METABOLIC FLUX AND FITNESS: ALCOHOL DEHYDROGENASE IN DROSOPHILA MELANOGASTER

1983 • 115 citations

Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast

1986 • 108 citations

Kinetics of metabolic pathways. A system in vitro to study the control of flux

1986 • 103 citations

Fitness as a function of β-galactosidase activity inEscherichia coli

1986 • 92 citations

Enzyme‐enzyme interactions and control analysis

1990 • 89 citations

Enzyme‐enzyme interactions and control analysis

1990 • 79 citations

Control of oxidative phosphorylations in yeast mitochondria. Role of the phosphate carrier

1986 • 66 citations

Determination of Flux Control Coefficients from transient metabolite concentrations

1992 • 62 citations

ANALYSIS OF SEQUENTIAL REACTIONS

1963 • 62 citations

Interaction of upstream stimulatory factor with the human heme oxygenase gene promoter

1990 • 62 citations

Control analysis of photosynthetic sucrose synthesis: assignment of elasticity coefficients and flux-control coefficients to the cytosolic fructose 1,6-bisphosphatase and sucrose phosphate synthase

1989 • 39 citations

Control of Metabolism

1987 • 39 citations

An Analysis of the Control of Phosphorylation-Coupled Respiration in Isolated Plant Mitochondria

1989 • 30 citations

Stimulation by glucose of gluconeogenesis in hepatocytes isolated from starved rats

1987 • 27 citations

Enzyme kinetics and metabolic control. A method to test and quantify the effect of enzymic properties on metabolic variables

1990 • 17 citations

Anti-sense RNA as a tool to study plant gene expression

1988 • 15 citations

Tryptophan accumulation in Saccharomyces cerevisiae under the influence of an artificial yeast TRP gene cluster

1987 • 14 citations

Theoretical analysis of double-titration experiments

1987 • 5 citations

Flux Control Coefficients of Glycinamide Ribonucleotide Transformylase for de novo Purine Biosynthesis

1990 • 3 citations