Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

1999 • 2,565 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of Thalidomide Analogues That Are Potent Inhibitors of TNF-α

1999 • 618 citations

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1996 • 582 citations

Thalidomide Costimulates Primary Human T Lymphocytes, Preferentially Inducing Proliferation, Cytokine Production, and Cytotoxic Responses in the CD8+ Subset

1998 • 576 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity

1999 • 490 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

The Influence of Thalidomide on the Clinical and Immunologic Manifestation of Erythema Nodosum Leprosum

1993 • 379 citations

Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade

1996 • 295 citations

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

1999 • 252 citations

Response patterns of purified myeloma cells to hematopoietic growth factors

1989 • 231 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 221 citations

Cytochrome c-dependent and -independent Induction of Apoptosis in Multiple Myeloma Cells

1997 • 200 citations

CD40 ligand triggered interleukin-6 secretion in multiple myeloma

1995 • 198 citations

Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism

1997 • 174 citations

RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells

1999 • 119 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 90 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 85 citations

Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells.

1997 • 64 citations

Isolation and characterization of human multiple myeloma cell enriched populations

2000 • 46 citations

Interleukin-6 Overcomes p21WAF1 Upregulation and G1 Growth Arrest Induced by Dexamethasone and Interferon-γ in Multiple Myeloma Cells

1997 • 33 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 25 citations

Thalidomide: Therapeutic potential in hematologic malignancies

2000 • 9 citations