Uroporphyrinogen decarboxylase

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Ciba Foundation Symposium

1957 • 1,100 citations

PORPHYRIN BIOSYNTHESIS IN ERYTHROCYTES

1958 • 263 citations

Is hepatitis C virus infection a trigger of porphyria cutanea tarda?

1993 • 193 citations

Familial and sporadic porphyria cutanea

1978 • 181 citations

Macrocyclic intermediates in the biosynthesis of porphyrins

1976 • 139 citations

Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III.

1983 • 138 citations

IMMUNOREACTIVE UROPORPHYRINOGEN DECARBOXYLASE IN THE LIVER IN PORPHYRIA CUTANEA TARDA

1985 • 132 citations

Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes

1992 • 125 citations

Uroporphyrin formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug-metabolizing activity

1974 • 96 citations

Uroporphyrinogen Decarboxylase Structural Mutant (Gly281→Glu) in a Case of Porphyria

1986 • 95 citations

Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseases

1986 • 86 citations

Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers.

1983 • 81 citations

Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d

1989 • 78 citations

Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase

1983 • 75 citations

Recent Advances in Dermatology

1990 • 73 citations

Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda.

1990 • 69 citations

Structure of the gene for human uroporphyrinogen decarboxylase

1987 • 67 citations

Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2

1992 • 67 citations

Some kinetic properties of human red cell uroporphyrinogen decarboxylase

1980 • 66 citations

Drug-induced accumulation of uroporphyrin in chicken hepatocyte cultures. Structural requirements for the effect and role of exogenous iron

1984 • 65 citations

Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins

1981 • 64 citations

Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria

1988 • 63 citations

Immunoreactive uroporphyrinogen decarboxylase is unchanged in porphyria caused by TCDD and hexachlorobenzene

1982 • 62 citations

Order of uroporphyrinogen III decarboxylation on incubation of porphobilinogen and uroporphyrinogen III with erythrocyte uroporphyrinogen decarboxylase

1993 • 61 citations

Chemically-induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in inbred mice with iron overload

1987 • 61 citations

Uroporphyrinogen decarboxylase from mouse spleen

1971 • 59 citations

Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells

1991 • 59 citations

Evidence for cytochrome P450-mediated oxidation of uroporphyrinogen by cell-free liver extracts from chick embryos treated with 3-methylcholanthrene

1987 • 58 citations

A point mutation in the coding region of uroporphyrinogen decarboxylase associated with familial porphyria cutanea tarda

1989 • 58 citations

Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties

1970 • 57 citations

Analysis of uroporphyrinogen decarboxylase complementary DNAs in sporadic porphyria cutanea tarda

1993 • 57 citations

In vitro inhibitory effect on porphyrinogen carboxylyase of liver extracts from tcdd treated mice

1984 • 56 citations

Transformation of porphobilinogen into porphyrins by preparations from human erythrocytes

1964 • 55 citations

Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide

1986 • 55 citations

Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver

1983 • 54 citations

A Mutation (G281E) of the Human Uroporphyrinogen Decarboxylase Gene Causes Both Hepatoerythropoietic Porphyria and Overt Familial Porphyria Cutanea Tarda: Biochemical and Genetic Studies on Spanish Patients

1995 • 53 citations

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

1990 • 53 citations

Oxidation of uroporphyrinogens by hydroxyl radicals Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decar☐ylase

1988 • 52 citations

Molecular Defects of Uroporphyrinogen Decarboxylase in a Patient with Mild Hepatoerythropoietic Porphyria

1994 • 51 citations

Genetic variation of iron-induced uroporphyria in mice

1993 • 48 citations

Genetics and pathogenesis of human uroporphyrinogen decarboxylase defects

1989 • 48 citations

Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid

1988 • 48 citations

Nucleotide sequence of the Synechococcus sp. PCC7942 branching enzyme gene (glgB): expression in Bacillus subtilis

1990 • 48 citations

Role of iron in the hydrogen peroxide-dependent oxidation of hexahydroporphyrins (porphyrinogens): a possible mechanism for the exacerbation by iron of hepatic uroporphyria.

1988 • 47 citations

Experimental porphyrias as models for human hepatic porphyrias.

1977 • 45 citations

Heterogeneity of familial porphyria cutanea tarda.

1988 • 45 citations

Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation

1990 • 44 citations

Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: Comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations

1987 • 44 citations

Studies on the action of porphyrinogenic trace metals on the activity of hepatic uroporphyrinogen decarboxylase

1981 • 43 citations

Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytes

1990 • 43 citations

The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity

1989 • 42 citations

Mechanism of iron potentiation of hepatic uroporphyria: Studies in cultured chick embryo liver cells

1989 • 41 citations

Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides

1993 • 40 citations

Molecular genetic linkage maps of mouse chromosomes 4 and 6

1991 • 39 citations

Identification of a new mutation responsible for hepatoerythropoietic porphyria

1991 • 38 citations

Erythrocyte uropophyrinogen decarboxylase activity in porphyria cutanea tarda: A study of 40 consecutive patients

1989 • 37 citations

Porphyrin biosynthesis. X. Porphyrinogen carboxy-lyase from avian erythrocytes futher properties

1973 • 36 citations

Purification and properties of uroporphyrinogen decarboxylase from Saccharomyces cerevisiae

1990 • 34 citations

Cloning and sequencing of the hemE gene encoding uroporphyrinogen III decarboxylase (UPD) from Escherichia coli K-12

1993 • 34 citations

Investigations on the presence of porphyrinogen carboxy-lyase inhibitor in the liver of rats intoxicated with hexachlorobenzene

1980 • 33 citations

Characterization of a new mutation (R292G) and a deletion at the human uroporphyrinogen decarboxylase locus in two patients with hepatoerythropoietic porphyria

1992 • 31 citations

Studies on porphyrin metabolism in the kidney. Effects of trace metals and glutathione on renal uroporphyrinogen decarboxylase.

1984 • 29 citations

Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria

1986 • 28 citations

Uroporphyrinogen decarboxylase in Saccharomyces cerevisiae

1992 • 28 citations

Erythrocyte uroporphyrinogen decarboxylase activity in 80 unrelated patients with porphyria cutanea tarda

1992 • 27 citations

In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions

1986 • 24 citations

The Modification of Acetate and Propionate Side Chains During the Biosynthesis of Haem and Chlorophylls: Mechanistic and Stereochemical Studies

2007 • 20 citations

Effects of iron‐EDTA on uroporphyrinogen oxidation by liver microsomes

1989 • 19 citations

Studies on the active centre of rat liver porphyrinogen carboxylyase in vivo effect of hexachlorobenzene

1991 • 19 citations

Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds

1988 • 19 citations

Porphyrin biosynthesis in rhodopseudomonas palustris—V. Purification of porphyrinogen decarboxylase and some unusual properties

1986 • 18 citations

Iron and uroporphyrin in hepatocytes of inbred mice in experimental porphyria: A biochemical and morphological study

1991 • 17 citations

Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles

1992 • 17 citations

The effect of desferrioxamine on iron metabolism and lipid peroxidation in hepatocytes of C57BL/10 mice in experimental uroporphyria

1993 • 16 citations

Effect of the protoporphyrinogen oxidase-inhibiting herbicide fomesafen on liver uroporphyrin and heptacarboxylic porphyrin in two mouse strains

1994 • 14 citations

Development of hexachlorobenzene porphyria in rats: Time sequence and relationship with lipid peroxidation

1989 • 13 citations

Uroporphyrinogen decarboxylases from human erythrocytes: Purification, complete separation and partial characterization of two isoenzymes

1992 • 10 citations

Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture. II.

1992 • 8 citations

Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture

1989 • 6 citations