High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

A dot-immunobinding assay for monoclonal and other antibodies

1982 • 2,219 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

1983 • 337 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships.

1983 • 307 citations

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

1980 • 286 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes

1980 • 228 citations

Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.

1980 • 152 citations

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases.

1985 • 148 citations

Immunochemical relatedness of rat hepatic microsomal cytochromes P-450c and P-450d.

1982 • 121 citations

Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes.

1984 • 101 citations

Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions

1981 • 85 citations

Microsomes and drug oxidations

1989 • 76 citations

Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450

1988 • 63 citations

Reconstituted mammalian mixed-function oxidases: Requirements, specificities and other properties

1978 • 63 citations

Phenacetin metabolism: Effect of hydrocarbons and cigarette smoking

1977 • 43 citations

Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat

1988 • 40 citations

Phenacetin O‐deethylase: an activity of a cytochrome P‐450 showing genetic linkage with that catalysing the 4‐hydroxylation of debrisoquine?

1985 • 34 citations

[2] Proteins and polypeptides as antigens

1980 • 31 citations

Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene.

1987 • 28 citations

Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene

1985 • 28 citations

An assay for paracetamol, produced by the O-deethylation of phenacetinin vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry

1986 • 26 citations

Inter-relatedness of some isoenzymes of cytochrome P-450 from rat, rabbit and human, determined with monoclonal antibodies

1986 • 25 citations

Monoclonal antibodies to rabbit liver cytochrome P-448

1981 • 23 citations

A monoclonal antibody raised to rat liver cytochrome P-448 (form c) which recognises an epitope common to many other forms of cytochrome P-450

1985 • 21 citations

PhenacetinO-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds

1987 • 11 citations