Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Identification of protein coding regions by database similarity search

1993 • 1,660 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

Initiation of translation in prokaryotes and eukaryotes

1999 • 1,379 citations

Pfam: A comprehensive database of protein domain families based on seed alignments

1997 • 1,211 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Moonlighting proteins

1999 • 1,022 citations

New Goals for the U.S. Human Genome Project: 1998-2003

1998 • 848 citations

A Gene Map of the Human Genome

1996 • 737 citations

Statistics of local complexity in amino acid sequences and sequence databases

1993 • 735 citations

Non-globular domains in protein sequences: Automated segmentation using complexity measures

1994 • 537 citations

GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support.

1998 • 460 citations

Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences

1998 • 456 citations

CpG islands and genes

1995 • 449 citations

Construction and characterization of a normalized cDNA library.

1994 • 411 citations

Pieces of the puzzle: expressed sequence tags and the catalog of human genes

1997 • 380 citations

Analysis of expressed sequence tags indicates 35,000 human genes

2000 • 367 citations

Prediction of the Coding Sequences of Unidentified Human Genes. I. The Coding Sequences of 40 New Genes (KIAA0001-KIAA0040) Deduced by Analysis of Randomly Sampled cDNA Clones from Human Immature Myeloid Cell Line KG-1 (Supplement)

1994 • 362 citations

Systematic subcellular localization of novel proteins identified by large‐scale cDNA sequencing

2000 • 356 citations

Modulation of the Fate of Cytoplasmic mRNA by AU-Rich Elements: Key Sequence Features Controlling mRNA Deadenylation and Decay

1997 • 352 citations

Increased coverage of protein families with the Blocks Database servers

2000 • 336 citations

Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence

2000 • 324 citations

Zinc-Dependent Structure of a Single-Finger Domain of Yeast ADR1

1988 • 314 citations

Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins

1989 • 306 citations

How many genes in the human genome?

1994 • 298 citations

Gene Index analysis of the human genome estimates approximately 120,000 genes

2000 • 282 citations

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs

2000 • 279 citations

The Mammalian Gene Collection

1999 • 277 citations

Specific-primer-directed DNA sequencing

1986 • 264 citations

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI

2000 • 247 citations

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

1997 • 209 citations

Statistical Analysis of the 5′ Untranslated Region of Human mRNA Using “Oligo-Capped” cDNA Libraries

2000 • 141 citations

Alternative splicing of human genes: more the rule than the exception?

1999 • 125 citations

Prediction of the Coding Sequences of Unidentified Human Genes. XVII. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro

2000 • 124 citations

Prediction of protein function from sequence properties

1984 • 100 citations

PEDANTic genome analysis

1997 • 90 citations

Primer design for large scale sequencing

1998 • 88 citations

PATMAT: a searching and extraction program for sequence, pattern and block queries and databases

1992 • 64 citations

Simultaneous On-line DNA Sequencing on Both Strands with Two Fluorescent Dyes

1995 • 40 citations

ProSearch: fast searching of protein sequences with regular expression patterns related to protein structure and function.

1992 • 31 citations

Alternative mRNA splicing: the Shaker gene

1988 • 23 citations

Databases of mRNA untranslated regions for metazoa

1996 • 20 citations

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