CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

1999 • 2,358 citations

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

1999 • 2,117 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Development of anti-TNF therapy for rheumatoid arthritis

2002 • 673 citations

Cytokines and autoimmunity

2002 • 663 citations

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

1997 • 513 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

The genetics of complex autoimmune diseases: non-MHC susceptibility genes

2001 • 394 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis

2002 • 327 citations

Collagen-induced arthritis, an animal model of autoimmunity

1997 • 308 citations

Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.

1989 • 307 citations

T cell activation via Leu-23 (CD69).

1989 • 296 citations

Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes.

1988 • 283 citations

Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.

1993 • 280 citations

The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases

2000 • 276 citations

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.

1990 • 264 citations

Active and latent forms of transforming growth factor beta activity in synovial effusions.

1989 • 258 citations

Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.

1986 • 250 citations

Protection from Collagen-Induced Arthritis in Granulocyte-Macrophage Colony-Stimulating Factor-Deficient Mice

1998 • 233 citations

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.

1991 • 226 citations

Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis

2000 • 214 citations

A genome scan localizes five non–MHC loci controlling collagen–induced arthritis in rats

1996 • 212 citations

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.

1985 • 210 citations

Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.

1991 • 203 citations

Enhanced Antitumor Immunity in Mice Deficient in CD69

2003 • 176 citations

DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.

1997 • 150 citations

Severe inflammatory arthritis and lymphadenopathy in the absence of TNF

2001 • 147 citations

Molecular characterization of the early activation antigen CD69: A type II membrane glycoprotein related to a family of natural killer cell activation antigens

1993 • 147 citations

A potential role for CD69 in thymocyte emigration

2002 • 144 citations

Functional characterization of an antigen involved in an early step of T-cell activation.

1987 • 120 citations

Evaluation of TNF-α and IL-1 Blockade in Collagen-Induced Arthritis and Comparison with Combined Anti-TNF-α/Anti-CD4 Therapy

2000 • 119 citations

Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium.

1990 • 112 citations

TGF-β1 Somatic Gene Therapy Prevents Autoimmune Disease in Nonobese Diabetic Mice

1998 • 112 citations

The Generation of Mature, Single-Positive Thymocytes In Vivo Is Dysregulated by CD69 Blockade or Overexpression

2002 • 104 citations

Reduction of interleukin‐17–induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin‐4

2000 • 100 citations

Tumor necrosis factor‐α production induced in T lymphocytes through the AIM/CD69 activation pathway

1992 • 97 citations

Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice

2000 • 95 citations

Expression of a novel activation antigen on intrahepatic CD8+ T lymphocytes in viral chronic active hepatitis

1990 • 92 citations

Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases

2002 • 84 citations

Mapping autoimmunity genes

1999 • 83 citations

Activation of Peripheral Blood T Cells by Interaction and Migration Through Endothelium: Role of Lymphocyte Function Antigen-1/Intercellular Adhesion Molecule-1 and Interleukin-15

1999 • 77 citations

Localization of non-Mhccollagen-induced arthritis susceptibility loci in DBA/1j mice

1999 • 76 citations

Functional Analysis of Ligand-Binding and Signal Transduction Domains of CD69 and CD23 C-Type Lectin Leukocyte Receptors

2000 • 43 citations

The CD69 activation pathway in rheumatoid arthritis synovial fluid t cells

1996 • 21 citations

Anti-CD69 Autoantibodies Cross-React with Low Density Lipoprotein Receptor-Related Protein 2 in Systemic Autoimmune Diseases

2001 • 19 citations