A Secretory Cl Channel from Epithelial Cells Studied in Heterologous Expression Systems

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1991 • 689 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis

1986 • 568 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1991 • 498 citations

The Cystic Fibrosis Transmembrane Conductance Regulator

1993 • 438 citations

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

1988 • 419 citations

Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

1992 • 418 citations

Chloride and potassium channels in cystic fibrosis airway epithelia

1986 • 392 citations

Separate Cl- conductances activated by cAMP and Ca2+ in Cl(-)-secreting epithelial cells.

1990 • 360 citations

Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells

1987 • 341 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Anion selectivity in biological systems

1977 • 297 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver

1976 • 295 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Cl ^- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase

1989 • 267 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Multi-ion pore behaviour in the CFTR chloride channel

1993 • 250 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

Abnormal regulation of ion channels in cystic fibrosis epithelia

1990 • 236 citations

Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains

1992 • 231 citations

Regulation of Chloride Channels by Protein Kinase C in Normal and Cystic Fibrosis Airway Epithelia

1989 • 229 citations

Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia

1992 • 225 citations

Two types of chloride channel on duct cells cultured from human fetal pancreas

1989 • 224 citations

Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation

1992 • 214 citations

An Apical-Membrane Chloride Channel in Human Tracheal Epithelium

1986 • 206 citations

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

1991 • 196 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

CFTR!

1992 • 192 citations

Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells

1988 • 186 citations

Low‐conductance chloride channel activated by cAMP in the epithelial cell line T₈₄

1990 • 178 citations

Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.

1991 • 173 citations

Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding

1992 • 167 citations

A cAMP-Regulated Chloride Channel in Lymphocytes That Is Affected in Cystic Fibrosis

1989 • 163 citations

Properties of the luminal membrane of isolated perfused rat pancreatic ducts

1988 • 161 citations

Use ofXenopus oocytes for the functional expression of plasma membrane proteins

1990 • 155 citations

Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells

1990 • 155 citations

CaMKII mediates stimulation of chloride conductance by calcium in T84 cells

1991 • 143 citations

Cl?-channels in the apical cell membrane of the rectal gland ?induced? by cAMP

1985 • 129 citations

Chloride channels in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias)

1987 • 128 citations

Identification and regulation of whole-cell chloride currents in airway epithelium.

1989 • 117 citations

Persistence of Abnormal Chloride Conductance Regulation in Transformed Cystic Fibrosis Epithelia

1989 • 107 citations

CFTR channels in immortalized human airway cells

1992 • 106 citations

Regulation of Cl⁻ and K⁺ Channels in Airway Epithelium

1990 • 103 citations

Cystic Fibrosis Transmembrane Conductance Regulator: Nucleotide Binding to a Synthetic Peptide

1991 • 100 citations

Cystic Fibrosis: a disease of ion channels?

1987 • 98 citations

cAMP-activated Cl channels in CFTR-transfected cystic fibrosis pancreatic epithelial cells

1992 • 94 citations

The cystic fibrosis transmembrane conductance regulator. Effects of the most common cystic fibrosis-causing mutation on the secondary structure and stability of a synthetic peptide.

1992 • 92 citations

cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA

1992 • 91 citations

Identification and localization of a dogfish homolog of human cystic fibrosis transmembrane conductance regulator.

1991 • 89 citations

Chloride channel regulation in secretory epithelia.

1986 • 87 citations

Small linear chloride channels are endogenous to nonepithelial cells

1992 • 87 citations

Inhibition of an outwardly rectifying anion channel by HEPES and related buffers

1990 • 81 citations

Bicarbonate permeability of the outwardly rectifying anion channel

1989 • 73 citations

Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product.

1992 • 72 citations

The “small” conductance chloride channel in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias)

1987 • 72 citations

The cystic fibrosis transmembrane conductance regulator chloride channel. Iodide block and permeation

1992 • 69 citations

Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers.

1992 • 61 citations

Chapter 8 Chloride Channels in Epithelial Cells

1990 • 61 citations

Cystic fibrosis-- current topics

1993 • 61 citations

Cystic fibrosis gene expression is not correlated with rectifying Cl- channels.

1991 • 59 citations

Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein.

1992 • 53 citations

cGMP-dependent protein kinase regulation of a chloride channel in T84 cells

1992 • 52 citations

Phosphorylation‐activated chloride channels in human skin fibroblasts

1988 • 50 citations

Small conductance chloride channels in the apical membrane of thyroid cells

1990 • 48 citations

Characterization of a phosphorylation‐activated Cl‐selective channel in isolated Necturus enterocytes.

1989 • 46 citations

CFTR, a channel with the structure of a transporter

1992 • 44 citations

Cystic Fibrosis - Current Topics

1994 • 42 citations

Activation of normal and cystic fibrosis Cl- channels by voltage, temperature, and trypsin.

1989 • 40 citations

Cl^‐ Conductance and Acid Secretion in the Human Sweat Duct

1989 • 40 citations

Chloride channels on epithelial cells cultured from human fetal epididymis

1991 • 39 citations

Reversed anion selectivity in cultured cystic fibrosis sweat duct cells

1992 • 38 citations

T84 cells: anion selectivity demonstrates expression of Cl- conductance affected in cystic fibrosis

1992 • 37 citations

cAMP-activated chloride conductance in the colonic cell line, Caco-2

1992 • 37 citations

The basic defect in cystic fibrosis

1991 • 35 citations

Transformed sweat gland and nasal epithelial cell lines from control and cystic fibrosis individuals

1990 • 30 citations

Phosphorylation-regulated low-conductance Cl? channels in a human pancreatic duct cell line

1993 • 29 citations

Effect of modulation of protein kinase C on the cAMP‐dependent chloride conductance in T84 cells

1992 • 28 citations

Regulation of epithelial chloride channels by protein phosphatase

1991 • 22 citations

On the activation of outwardly rectifying anion channels in excised patches

1991 • 21 citations

cAMP-activated C1 conductance is expressed in Xenopus oocytes by injection of shark rectal gland mRNA

1991 • 20 citations

Possible Role of Outwardly Rectifying Anion Channels in Epithelial Transport^a

1989 • 17 citations

Characterisation of the effects of anthranilic and (indanyloxy) acetic acid derivatives on chloride transport in membrane vesicles

1991 • 10 citations

Conductance Pathways Involved in Chloride Secretion and Their Regulation

1991 • 6 citations

Chloride‐Transport Inhibitors in Vitro Do Not Inhibit Intestinal Fluid Secretion in Vivo

1989 • 6 citations

The Identification of the CF (Cystic Fibrosis) Gene

1991 • 5 citations

Cytosolic Inhibition and Excision Activation of Epithelial Chloride Channels

1991 • 3 citations

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