New oxazolidinones

Antibacterial resistance worldwide: causes, challenges and responses

2004 • 3,834 citations

Drugs for bad bugs: confronting the challenges of antibacterial discovery

2006 • 2,383 citations

Trends in Infectious Disease Mortality in the United States During the 20th Century

1999 • 831 citations

Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

1996 • 559 citations

Oxazolidinone Structure–Activity Relationships Leading to Linezolid

2003 • 509 citations

The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria

1998 • 506 citations

Inhibition of Mammalian Mitochondrial Protein Synthesis by Oxazolidinones

2006 • 258 citations

The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin

1997 • 257 citations

Mechanism of action of the oxazolidinone antibacterial agents

1999 • 206 citations

Serotonin Toxicity Associated with the Use of Linezolid: A Review of Postmarketing Data

2006 • 197 citations

THE DIVERSE AND DYNAMIC STRUCTURE OF BACTERIAL GENOMES

1998 • 181 citations

Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action

2000 • 164 citations

Recent developments in the identification of novel oxazolidinone antibacterial agents

2006 • 131 citations

Hematologic Effects of Antimicrobials: Focus on the Oxazolidinone Linezolid

2001 • 128 citations

Mechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis

1988 • 119 citations

Oxazolidinones Inhibit Cellular Proliferation via Inhibition of Mitochondrial Protein Synthesis

2005 • 101 citations

Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 4. Multiply-substituted aryl derivatives

1992 • 95 citations

The efficacy and safety of linezolid as treatment for Staphylococcus aureus infections in compassionate use patients who are intolerant of, or who have failed to respond to, vancomycin

2002 • 89 citations

Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors

1999 • 73 citations

Possibly Linezolid-Induced Peripheral and Central Neurotoxicity: Report of Four Cases

2005 • 72 citations

Synthesis of Conformationally Constrained Analogues of Linezolid: Structure−Activity Relationship (SAR) Studies on Selected Novel Tricyclic Oxazolidinones

2002 • 68 citations

The mechanism of action of DuP 721, a new antibacterial agent: Effects on macromolecular synthesis

1988 • 60 citations

Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid

2005 • 56 citations

Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480

2004 • 56 citations

Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid

2005 • 50 citations

Antibiotics—Past, Present, and Future

2006 • 49 citations

In Vitro Activity of the Oxazolidinone RWJ-416457 against Linezolid-Resistant and -Susceptible Staphylococci and Enterococci

2007 • 46 citations

Synthesis and antibacterial activity of new N-linked 5-triazolylmethyl oxazolidinones

2005 • 41 citations

Structure–antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones

2006 • 39 citations

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

2004 • 39 citations

Antimycobacterial Activities of Oxazolidinones: A Review

2006 • 37 citations

3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: A novel class of antibacterial agents

2006 • 29 citations

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

2006 • 29 citations

In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria

2003 • 28 citations

Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect

2004 • 24 citations

The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones

2004 • 23 citations

Recent advances in oxazolidinone antibacterial agent research

2004 • 23 citations

Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials

2005 • 22 citations

Biaryl isoxazolinone antibacterial agents

2005 • 22 citations

In Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457

2006 • 21 citations

In vitro efficacy of Linezolid on clinical strains of Mycobacterium tuberculosis and other mycobacteria.

2006 • 21 citations

Role of linezolid in the treatment of complicated skin and soft tissue infections

2006 • 19 citations

New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics

2006 • 18 citations

A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones

2005 • 17 citations

Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

2006 • 17 citations

Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent

2006 • 16 citations

Synthesis of novel oxazolidinone derivatives for antibacterial investigation

2005 • 12 citations

Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones

2006 • 11 citations

Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones

2006 • 11 citations

Use of linezolid in children: an overview of recent advances

2006 • 9 citations

In Vitro and In Vivo Activities of DA-7867, a New Oxazolidinone, against Aerobic Gram-Positive Bacteria

2005 • 8 citations

Effects of acute renal failure on the pharmacokinetics of DA‐7867, a new oxazolidinone, in rats

2005 • 3 citations

LINEZOLID: THE FIRST OXAZOLIDINONE ANTIMICROBIAL

2002 • 3 citations

Linezolid for the treatment of diabetic foot infections

2006 • 1 citations