Antibacterial resistance worldwide: causes, challenges and responses

Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

2001 • 2,554 citations

Comparison of Mortality Associated with Methicillin‐Resistant and Methicillin‐SusceptibleStaphylococcus aureusBacteremia: A Meta‐analysis

2003 • 1,932 citations

Community-Acquired Methicillin-ResistantStaphylococcus aureusCarrying Panton-Valentine Leukocidin Genes: Worldwide Emergence

2003 • 1,733 citations

Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis

2004 • 1,696 citations

Community-Acquired Methicillin-Resistant <EMPH TYPE="ITAL">Staphylococcus aureus</EMPH> in Children With No Identified Predisposing Risk

1998 • 1,435 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland

1997 • 1,221 citations

Quinolone resistance from a transferable plasmid

1998 • 1,116 citations

Multidrug efflux pumps of gram-negative bacteria

1996 • 1,071 citations

The Challenge of Antibiotic Resistance

1998 • 873 citations

Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus

2003 • 869 citations

Treatment of Multidrug-Resistant Tuberculosis

1993 • 722 citations

Emerging carbapenemases in Gram-negative aerobes

2002 • 688 citations

Genetics and mechanisms of glycopeptide resistance in enterococci

1993 • 677 citations

Resistance to Antibiotics Mediated by Target Alterations

1994 • 671 citations

International Prospective Study of Klebsiella pneumoniae Bacteremia: Implications of Extended-Spectrum β-Lactamase Production in Nosocomial Infections

2004 • 618 citations

Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution

1996 • 617 citations

Promoting resistance by the emission of antibiotics from hospitals and households into effluent

2003 • 562 citations

Factors impacting on the problem of antibiotic resistance

2002 • 546 citations

Widespread Distribution of Urinary Tract Infections Caused by a Multidrug-ResistantEscherichia coliClonal Group

2001 • 538 citations

Active efflux mechanisms for antimicrobial resistance

1992 • 500 citations

Why is big Pharma getting out of antibacterial drug discovery?

2003 • 500 citations

Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon

1997 • 461 citations

The impact of antibiotic use on resistance development and persistence

2000 • 461 citations

The Economic Impact ofStaphylococcus aureusInfection in New York City Hospitals

1999 • 443 citations

Health and Economic Impacts of Antimicrobial Resistance

1987 • 424 citations

New -Lactamases in Gram-Negative Bacteria: Diversity and Impact on the Selection of Antimicrobial Therapy

2001 • 394 citations

Trends in Antimicrobial Resistance among Urinary Tract Infection Isolates of Escherichia coli from Female Outpatients in the United States

2002 • 380 citations

Vancomycin-Resistant Staphylococcus aureus Isolate from a Patient in Pennsylvania

2003 • 379 citations

INFECTION BY PENICILLIN-RESISTANT STAPHYLOCOCCI

1948 • 360 citations

Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family

1996 • 357 citations

Gram-Positive Pathogens

2006 • 351 citations

Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systematic review of the literature

2004 • 351 citations

Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a Farm

1976 • 350 citations

INFECTIVE HEREDITY OF MULTIPLE DRUG RESISTANCE IN BACTERIA

1963 • 337 citations

Carbapenemases: a problem in waiting?

2000 • 333 citations

Evidence for the Introduction of a Multiresistant Clone of Serotype 6B Streptococcus pneumoniae from Spain to Iceland in the Late 1980s

1993 • 326 citations

Antimicrobial Resistance to Linezolid

2004 • 311 citations

Vancomycin-Intermediate and -Resistant Staphylococcus aureus: What the Infectious Disease Specialist Needs to Know

2001 • 310 citations

Mechanisms of Fluoroquinolone Resistance: An Update 1994-1998

1999 • 297 citations

Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litter

2004 • 292 citations

Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical Escherichia coli Strains from China: Role of acrR Mutations

2001 • 283 citations

Conjugative Transposons and the Dissemination of Antibiotic Resistance in Streptococci

1986 • 276 citations

Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patients

2003 • 267 citations

Controlling Antimicrobial Resistance in Hospitals: Infection Control and Use of Antibiotics

2001 • 261 citations

Antibiotic Resistance: Consequences of Inaction

2001 • 256 citations

Streptomycin Resistance in Pulmonary Tuberculosis

1948 • 250 citations

Emerging Plasmid-Mediated Quinolone Resistance Associated with the qnr Gene in Klebsiella pneumoniae Clinical Isolates in the United States

2004 • 240 citations

Vancomycin resistance in staphylococci

1998 • 237 citations

Origin and Interstate Spread of a New York City Multidrug-Resistant Mycobacterium tuberculosis Clone Family

1996 • 236 citations

Generally Overlooked Fundamentals of Bacterial Genetics and Ecology

2002 • 235 citations

Antibiotic Resistance: An Ecological Imbalance

2007 • 230 citations

Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States

2003 • 223 citations

Gene transfer in the environment

1990 • 218 citations

Uses of Antimicrobials in Plant Agriculture

2002 • 209 citations

Nomenclature for New Tetracycline Resistance Determinants

1999 • 209 citations

Origin and molecular epidemiologY of penicillin-binding-protein-mediated resistance to β-lactam antibiotics

1994 • 195 citations

Frequency of Disinfectant Resistance Genes and Genetic Linkage with β-Lactamase Transposon Tn 552 among Clinical Staphylococci

2002 • 195 citations

MICROBIAL RESISTANCE TO ANTIBIOTICS

1982 • 181 citations

Relationship between Fluoroquinolone Use and Changes in Susceptibility to Fluoroquinolones of Selected Pathogens in 10 United States Teaching Hospitals, 1991-2000

2003 • 169 citations

High frequency of antimicrobial resistance in human fecal flora

1988 • 164 citations

Antimicrobial Activity of Quinupristin-Dalfopristin (RP 59500, Synercid®) Tested against Over 28,000 Recent Clinical Isolates from 200 Medical Centers in the United States and Canada

1998 • 163 citations

Gene transfer in the environment

1989 • 161 citations

BAD HABITS ARE NOT DISEASES

1972 • 152 citations

Role of AcrR and RamA in Fluoroquinolone Resistance in Clinical Klebsiella pneumoniae Isolates from Singapore

2003 • 152 citations

Balancing the drug-resistance equation

1994 • 150 citations

Mobile Gene Cassettes and Integrons in Evolution

1999 • 150 citations

Microbiology and drug resistance mechanisms of fully resistant pathogens

2004 • 146 citations

Antimicrobial Resistance of Neisseria gonorrhoeae and High Prevalence of Ciprofloxacin-Resistant Isolates in Japan, 1993 to 1998

2000 • 143 citations

Plasmid-Mediated Beta-Lactamase Production in Neisseria gonorrhoeae

1977 • 137 citations

Antibiotic-resistant bacteria in wild primates: increased prevalence in baboons feeding on human refuse

1985 • 135 citations

Bug/drug resistance. Sometimes less is more.

1989 • 129 citations

Inter- and intraspecies spread of Escherichia coli in a farm environment in the absence of antibiotic usage.

1990 • 126 citations

R FACTORS IN ESCHERICHIA COLI IN FÆCES AFTER ORAL CHEMOTHERAPY IN GENERAL PRACTICE

1971 • 104 citations

Can better prescribing turn the tide of resistance?

2004 • 103 citations

Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to Streptococcus pneumoniae

2003 • 103 citations

Multidrug‐ResistantNeisseria gonorrhoeaewith Decreased Susceptibility to Cefixime—Hawaii, 2001

2003 • 100 citations

Common R-plasmids in Staphylococcus aureus and Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak

1982 • 97 citations

Sequential antibiotic therapy for acne promotes the carriage of resistant staphylococci on the skin of contacts

1996 • 97 citations

Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin

2004 • 96 citations

Bug/Drug Resistance

1989 • 93 citations

Carriage of Antibiotic‐Resistant Fecal Bacteria in Nepal Reflects Proximity to Kathmandu

2001 • 87 citations

Molecular nature of two beta-lactamase-specifying plasmids isolated from Haemophilus influenzae type b

1976 • 85 citations

Plasmid-Mediated Chloramphenicol Resistance in Haemophilus influenzae

1977 • 79 citations

Emergence of Antibiotic-Resistant Bacteria in the Intestinal Flora of Farm Inhabitants

1978 • 72 citations

A national survey of antimicrobial resistance in Staphylococcus aureus in Australian teaching hospitals

1989 • 57 citations

Homogeneity of Transferable Tetracycline-Resistance Determinants in Haemophilus Species

1984 • 56 citations

Targeting virulence to prevent infection: to kill or not to kill?

2004 • 43 citations

Drug discovery today. Therapeutic strategies

2013 • 43 citations

Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

1977 • 43 citations

ANTIBIOTIC-RESISTANT BACTERIA IN FOOD OF MAN AND ANIMALS

1984 • 27 citations

Sometimes Less is More

1999 • 26 citations

Introduction

2002 • 26 citations

The epidemiology of vancomycin-resistant enterococci

1999 • 24 citations

The Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Powers

2003 • 24 citations

Antibiotic resistance: Origins, evolution and spread

1996 • 12 citations