Deregulation of Collagen Phagocytosis in Aging Human Fibroblasts: Effects of Integrin Expression and Cell Cycle

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling

1996 • 341 citations

Dependence of collagen remodelling on α‐smooth muscle actin expression by fibroblasts

1994 • 275 citations

The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro

1966 • 271 citations

Replicative senescence of human fibroblast-like cells in culture

1993 • 270 citations

Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.

1996 • 237 citations

A comparison of the rates of synthesis and turnover of collagen and non-collagen proteins in adult rat periodontal tissues and skin using a microassay

1977 • 230 citations

Migration and division of progenitor cell populations in periodontal ligament after wounding

1980 • 222 citations

Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production

1991 • 190 citations

Morphological studies of fibrocytes in connective tissue undergoing rapid remodelling.

1972 • 185 citations

Inhibition of collagen-induced platelet aggregation as the result of cleavage of α2β1-integrin by the snake venom metalloproteinase jararhagin

1996 • 169 citations

Cell density and cell generation in the periodontal ligament of mice

1983 • 167 citations

Cell heterogeneity during the cell cycle

1982 • 157 citations

Phagocytosis and digestion of collagen by gingival fibroblasts in vivo: A study of serial sections

1981 • 146 citations

Role of integrins in regulation of collagen phagocytosis by human fibroblasts

1996 • 143 citations

TNF-alpha inactivation of collagen receptors: implications for fibroblast function and fibrosis.

1996 • 125 citations

Current views of collagen degeradation. Progress towards understanding the resorption of connective tissues

1985 • 121 citations

Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area

1991 • 113 citations

Bovine spleen cathepsin B1 and collagenolytic cathepsin. A comparative study of the properties of the two enzymes in the degradation of native collagen

1976 • 97 citations

Lysosomal enzymes and aging in vitro: Subcellular enzyme distribution and effect of hydrocortisone on cell life-span☆

1975 • 92 citations

The Digestion of Phagocytosed Collagen is Inhibited by the Proteinase Inhibitors Leupeptin and E-64

1985 • 91 citations

Deficiencies in collagen phagocytosis by human fibroblasts in vitro: A mechanism for fibrosis?

1993 • 84 citations

Mechanism of collagen phagocytosis by human gingival fibroblasts: importance of collagen structure in cell recognition and internalization

1991 • 83 citations

Cyclosporine-induced gingival overgrowth: An ultrastructural stereologic study

1988 • 72 citations

A stereologic analysis of collagen phagocytosis by fibroblasts in three soft connective tissues with differing rates of collagen turnover

1981 • 66 citations

Regulation of collagenase and collagenase mRNA production in early‐ and late‐passage human diploid fibroblasts

1989 • 66 citations

Aging of human fibroblasts is a succession of subtle changes in the cell cycle and has a final short stage with abrupt events

1982 • 65 citations

Ultrastructural Quantitation of Connective Tissue Changes in Phenytoin-induced Gingival Overgrowth in the Ferret

1982 • 58 citations

Isolation of autofluorescent ‘aged’ human fibroblasts by flow sorting

1982 • 52 citations

A Role for Collagen Phagocytosis by Fibroblasts in Scar Remodeling: An Ultrastrutural Stereologic Study

1983 • 48 citations

Relationship of cellular proliferation to expression of osteopontin and bone sialoprotein in regenerating rat periodontium

1996 • 48 citations

Collagenase production by early and late passage cultures of human fibroblasts

1989 • 45 citations

Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts

1991 • 41 citations

Role of the cellular attachment domain of fibronectin in the phagocytosis of beads by human gingival fibroblasts in vitro

1990 • 41 citations

Intracellular collagen in the nonpregnant and IUD‐containing rat uterus

1977 • 39 citations

Altered Expression and Regulation of the α5β1 Integrin–Fibronectin Receptor Lead to Reduced Amounts of Functional α5β1 Heterodimer on the Plasma Membrane of Senescent Human Diploid Fibroblasts

1996 • 36 citations

Effects of in vitro cellular aging on alkaline phosphatase, cathepsin activities and collagen secretion of human periodontal ligament derived cells

1996 • 36 citations

Adhesion to thrombospondin by human embryonic fibroblasts is mediated by multiple receptors and includes a role for glycoprotein 88 (CD36)

1992 • 35 citations

Cytokines modulate phagocytosis and intracellular digestion of collagen fibrils by fibroblasts in rabbit periosteal explants Inverse effects on procollagenase production and collagen phagocytosis

1995 • 34 citations

In vitro biosynthesis of type I and III collagens by human dermal fibroblasts from donors of increasing age

1994 • 33 citations

Discrimination of two fibroblast progenitor populations in early explant cultures of hamster gingiva

1991 • 32 citations

Regulation of proteins in the VLA cell substrate adhesion family: Influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression

1988 • 30 citations

The Effects of Aging upon the Connective Tissues of the Periodontal Ligament

1995 • 22 citations

Tumor Necrosis Factor-α Increased the Integrin α2β1 Expression and Cell Attachment to Type I Collagen in Human Dermal Fibroblasts

1993 • 20 citations

Age-related alterations in collagen and total protein metabolism determined in cultured rat dermal fibroblasts: Age-related trends parallel those observed in rat skin in vivo

1995 • 17 citations

Deficiency in integrin-mediated transmembrane signaling and microfilament stress fiber formation by aging dermal fibroblasts from normal and down's syndrome patients

1992 • 15 citations

Release from quiescence stimulates the expression of integrin α₅β₁ which regulates DNA synthesis in human fibrosarcoma HT1080 cells

1995 • 13 citations

Multinucleated fibroblastic cells in the periodontal ligaments of aged rats

1993 • 9 citations

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