Carcinogenesis and Aging

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Mutation and Cancer: A Model for Human Carcinogenesis2

1981 • 1,102 citations

Handbook of the Biology of Aging

1978 • 871 citations

ONCOGENES OF RNA TUMOR VIRUSES AS DETERMINANTS OF CANCER

1969 • 868 citations

Mammary Cancer Induced by a Single Feeding of Polynuclear Hydrocarbons, and its Suppression

1961 • 788 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

The Sequential Analysis of Cancer Development

1980 • 613 citations

Drug Disposition in Old Age

1982 • 589 citations

Cancer and ageing in mice and men

1975 • 466 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

Mesothelioma mortality in asbestos workers: Implications for models of carcinogenesis and risk assessment

1982 • 262 citations

Development of Tumors in the Rat Ovary After Transplantation into the Spleen.

1944 • 255 citations

DNA Damage as the Primary Cause of Aging

1981 • 248 citations

Longevity and Gross Pathology At Death in 22 Inbred Mouse Strains

1966 • 222 citations

Carcinogenesis and aging

1982 • 203 citations

Mutagenic and carcinogenic N-nitroso compounds: Possible environmental hazards

1976 • 201 citations

Body composition. Prediction of normal body potassium, body water and body fat in adults on the basis of body height, body weight and age

1980 • 192 citations

Quantitative Studies on the Multiplication of Neoplastic Cells in Vivo. I. Growth Curves of the Ehrlich and MClM Ascites Tumors2

1953 • 182 citations

The Relative Importance of Risk Factors in Nonmelanoma Carcinoma

1980 • 173 citations

Carcinogenesis as a biological problem

1976 • 163 citations

Free radical theory of aging: dietary implications

1972 • 152 citations

Increased Susceptibility of Down's Syndrome Fibroblasts to Transformation by SV10.

1967 • 151 citations

Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy

1974 • 133 citations

Patho-physiologic findings after chronic tryptophan deficiency in rats: A model for delayed growth and aging

1976 • 131 citations

Effect of Treatment with Phenformin, Diphenylhydantoin or <i>L</i>-Dòpa on Life Span and Tumour Incidence in C3H/Sn Mice

1980 • 128 citations

Biological aspects of aging

1962 • 127 citations

The aging gastrointestinal tract

1969 • 114 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

On the Possibility That DNA Repair Is Related to Age in Non-Dividing Cells

1974 • 108 citations

Tumors in CF-1 Mice Exposed for Six Consecutive Generations to DDT

1973 • 106 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals

1981 • 99 citations

Spontaneous Tumors and Common Diseases in Three Types of Hamsters2

1979 • 98 citations

Selenium and Tellurium in Rats: Effect on Growth, Survival and Tumors

1971 • 97 citations

Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of the donor species.

1980 • 95 citations

On the role of aging in cancer incidence

1980 • 93 citations

Cellular Basis and Ætiology of Late Somatic Effects of Ionizing Radiation

1964 • 91 citations

Selenium-mediated inhibition of mouse mammary tumorigenesis

1980 • 89 citations

Alkylation of DNA and tissue specificity in nitrosamine carcinogenesis

1981 • 88 citations

Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol

1979 • 86 citations

HOST ENVIRONMENT INTERACTIONS IN THE ETIOLOGY OF CANCER IN MAN

1973 • 85 citations

On the Multiform Relationships between the Tumor

1979 • 76 citations

An analysis of 346 cases of clear cell adenocarcinoma of the vagina and cervix with emphasis on recurrence and survival

1979 • 74 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

Influence of aging and induction on rat liver and kidney microsomal mixed function oxidase systems

1980 • 68 citations

Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system

1981 • 68 citations

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from patients with Huntington disease, familial dysautonomia, and other primary neuronal degenerations.

1981 • 68 citations

Effects of the type of dietary fat at two levels of vitamin E in wistar male rats during development and aging

1980 • 66 citations

Relative Reference Values for Clinical Chemical and Haematological Quantities in ‘Healthy’ Elderly People

1981 • 60 citations

Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells

1981 • 55 citations

Ageing, metabolic immunodepression and carcinogenesis

1978 • 52 citations

Senescent changes in rodent hepatic epoxide metabolism

1979 • 51 citations

Incidence Patterns of Spontaneous Tumors in BN/Bi Rats

1977 • 50 citations

Influence of gonadal hormones and age on 1,2- dimethylhydrazine-induced colon carcinogenesis

1977 • 50 citations

What Did the Blue Jay Do with the Nut?

1939 • 49 citations

Study of the Anti-Tumor Effect of Polypeptide Pineal Extract

1979 • 46 citations

Age and renal clearance of cimetidine

1982 • 45 citations

law of deviation of homeostasis and diseases of aging

1981 • 45 citations

Temporal Aspects of Occupational Bladder Carcinogenesis

1973 • 44 citations

Proliferative homeostasis and its age-related aberrations

1979 • 43 citations

Restoration of impaired immune functions in aging animals. II. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vitro

1979 • 42 citations

Human tumour xenografts in athymic rats and their age dependence

1982 • 42 citations

Inhibition of Fatty Acid Oxidation by Biguanides: Implications for Metabolic Physiopathology

1974 • 41 citations

Induction of hepatic mixed function oxidases in senescent rodents—II. Effect of polychlorinated biphenyls

1978 • 40 citations

Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice

1982 • 40 citations

Aging, Environmental Influences, and Photocarcinogenesis

1979 • 39 citations

Prevention of Spontaneous Tumors of Aged Mice by Immunopharmacologic Manipulation: Study of Immune Antitumor Mechanisms2

1981 • 39 citations

Correlation between species life span and capacity to activate 7,12-dimethylbenz(a)anthracene to a form mutagenic to a mammalian cell

1975 • 38 citations

Uterine, Vaginal and Mammary Tumours induced by Nitrosoureas in Pregnant Rats

1969 • 38 citations

Age-Related Modification of 7,12-Dimethylbenz[ a ]anthracene Binding to Rat Mammary Gland DNA 2

1978 • 37 citations

Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system

1979 • 37 citations

Mode of action of methylating carcinogens: comparative studies of murine and human cells

1981 • 37 citations

In vivo repair of rat intestinal dna damage by alkylating agents

2006 • 36 citations

Evolution of the distribution, proliferation and ultraviolet repair capacity of rat lens epithelial cells as a function of maturation and aging

1981 • 36 citations

Inverse correlation between species life span and capacity of cultured fibroblasts to bind 7,12-dimethylbenz(a)anthracene to DNA

1977 • 35 citations

Types of experimental delay in aging patterns

1978 • 34 citations

Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing

1981 • 33 citations

Effect of age on sensitivity of human lymphocytes to radiation. A brief note

1982 • 31 citations

Changes in the mechanisms of steroid action during aging

1979 • 30 citations

Aging and Cancerigenesis. II. Effect of Age on Phagocytic Activity of the Reticuloendothelial System and on Tumor Growth2

1965 • 30 citations

The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats

1980 • 29 citations

Transplacental effect of diethylstilbestrol in female rats

1979 • 28 citations

A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice

1977 • 28 citations

EPIDEMIOLOGICAL EVIDENCE FOR TWO COMPONENTS OF CERVICAL CANCER

1981 • 27 citations

Initiation and promotion at different ages and doses in 2200 mice. III. Linear extrapolation from high doses may underestimate low-dose tumour risks

1981 • 26 citations

Age-Dependence of Hepatic Dimethylnitrosamine-Demethylase Activity in the Rat2

1976 • 26 citations

Long-Term Treatment with Procaine (Gerovital H3) in Albino Rats

1965 • 26 citations

Modifying effect of aging on chemical carcinogenesis. A review

1981 • 25 citations

Effect of age at inoculation of asbestos on occurrence of mesotheliomas in rats

1976 • 24 citations

Influence of age and parity on the susceptibility of rat mammary gland epithelial cells in primary cultures to 7,12-dimethylbenz(a) anthracene

1981 • 23 citations

Pancreatic Carcinoma Induced by N-Methyl-N′-Nitrosourea in Aged Mice

1982 • 23 citations

Radiation Glomerulosclerosis and Other Late Effects: Influence of Radiological Factors and AET

1965 • 23 citations

Ageing decreases the activity of epidermal G1 and G2 inhibitors in mouse skin independent of grafting on old or young recipients

1977 • 22 citations

Mutagen sensitivity in peripheral lymphocytes as a risk indicator

1981 • 22 citations

Metabolic activation of aflatoxin B1 by liver tissue from male Fischer F344 rats of various ages

1981 • 21 citations

Tumoren nach einmaliger Röntgenbestrahlung weißer Ratten in verschiedenem Lebensalter

1964 • 21 citations

Does the Capacity to Rejoin Radiation-induced DNA Breaks Decline in Senescent Mice?

1978 • 21 citations

Effects of aging on the induction of angiosarcoma.

1981 • 20 citations

Carcinogenesis and aging

1981 • 19 citations

Ontogenetic variation in rat liver, lung and kidney monooxygenase induction by low doses of benzo(A)pyrene and cigarette-smoke condensate

1981 • 19 citations

Cell Renewal and Cell Loss in the Tissues of Aging Mammals1

2015 • 18 citations

Low level of u.v.-induced unscheduled DNA synthesis in postmitotic brain cells of hamsters: possible relevance to aging

1981 • 18 citations

Effect of Age on Tumor Induction In C57BL Mice

1974 • 18 citations

Effect of Age of Non-Skin Tissues on Susceptibility of Skin Grafts to 7,12-Dimethylbenz[ a ]anthracene (DMBA) Carcinogenesis in BALB/c Mice, and Effect of Age of Skin Graft on Susceptibility of Surrounding Recipient Skin to DMBA 2

1977 • 17 citations

Effect of age and sex on lung-colony-forming efficiency of injected mouse tumour cells

1976 • 17 citations

Differences in mouse mammary tumor viruses:Relationship to early and late occurring mammary tumors

1977 • 17 citations

Life Table Methodology for Evaluating Radiation Risk

1981 • 17 citations

Culture age and cellular radiosensitivity

1969 • 17 citations

Enhancement of Lewis lung carcinoma in a syngeneic host by spleen cells of C57BL/6 old mice

1977 • 16 citations

Influence of age and 3‐methylcholanthrene on azo‐dye carcinogenesis and metabolism of p‐dimethylaminoazobenzene in rat liver

1973 • 16 citations

Carcinogenesis and aging. II. Modifying effect of aging on metabolism of methyl(acetoxymethyl)nitrosamine and its interaction with DNA of various tissues in rats

1983 • 16 citations

The effect of hamster age on u.v.-induced unscheduled DNA synthesis in freshly isolated lung and kidney cells

1981 • 16 citations

Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats

1981 • 15 citations

Inverse Correlation Between Species Life Span and Specific Cytochrome P-448 Content of Cultured Fibroblasts

1982 • 15 citations

Age-related changes in mutagen activation by rat tissues

1982 • 14 citations

Experimentally-Induced Neoplasms in the Skin of Mice

1965 • 14 citations

Carcinogenesis and Aging

1978 • 13 citations

Proteins specified by Sindbis virus in chick embryo fibroblast cells

1973 • 13 citations

Inhibition of the carcinogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, phenytoin, pineal polypeptide extract, and L-dopa

1980 • 12 citations

The influence of age and pregnancy on immune responses of baboons to mitogens and the baboon endogenous virus

1981 • 12 citations

Age-Dependent Changes of DNA Replication in Rat Spleen and Kidney

1980 • 12 citations

Effect of ageing on concentration of estradiol in serum and the epidermal G2 chalone in vaginal mucosa of rats

1980 • 11 citations

Reduced spontaneous antitumour resistance of the elderly rat is restored by Corynebacterium parvum

1978 • 11 citations

Attempted Induction of Granulosa Cell Tumor in Balb-C Mice by Gonadotropin Administration

1977 • 11 citations

The Relationship between the Latent Period and Animal Age in the Development of Foreign Body Sarcomas

1975 • 11 citations

Effect of age of the donor on development of rat tumor grafts

1952 • 10 citations

Effect of age, castration, and pregnancy on carcinogenesis induced in CBA mice by 1,2-dimethylhydrazine

1979 • 9 citations

Influence of Age of Host on the Chemotherapy of Murine Myeloma LCP-1

1974 • 9 citations

Histopathology of Breast Lesions Induced in BUF Rats of Varying Ages by Ingestion of N-4-(4'-Fluorobiphenyl)acetamide

1975 • 9 citations

Activation of promutagens by liver homogenates isolated from female mice at different ages; lack of significant differences

1981 • 8 citations

Reduced prevalence and growth rate of urethane induced lung adenomas in ageing adult strain a mice

1981 • 8 citations

Age and susceptibility to reduction in life expectancy: An analysis of proposed mechanisms

1971 • 8 citations

Shortening of the Span of Life of Rats by ‘Myleran’

1964 • 8 citations

Incidence of spontaneous tumours in neonatally thymectomized rats

1978 • 8 citations

Age-related increases in mitogenic responses and natural immunity to a syngeneic fibrosarcoma in rats

1981 • 7 citations

Intestinal microflora and aging: Age-related change of enzymes in the liver and the small intestine of germ-free and conventional rats

1981 • 7 citations

ON THE MECHANISM OF EXPERIMENTAL CARCINOGENESIS

1953 • 7 citations

Brief Communication: Intramitochondrial Bodies in a Human Cell Line Carrying Oncornavirus-Like Particles2

1975 • 6 citations

Altered DNA Repair in Fibroblasts from Aged Rats

1981 • 6 citations

Effect of thymic and pineal polypeptide factors on radiation carcinogenesis

1982 • 6 citations

Density-dependent mitosis in the Walker 256 carcinoma and the influence of host age on growth

1978 • 6 citations

Effect of the age-related immune depression induced by MTV on the in vivo growth of a mammary carcinoma

1981 • 5 citations

Chemical Geroprotectors and the Problem of Increasing the Life Span

1975 • 5 citations

BLASTOMOGENIC EFFECT OF IONIZING RADIATION.

1972 • 5 citations

Osteosarcoma induced by short-lived bone-seeking α emitters in mice: The role of age

1979 • 4 citations

Age-dependent leukemia produced in thymectomized akr mice by antiserum to leukemic cells

1978 • 4 citations

Resistance of aged cells to virus replication

1979 • 3 citations

Susceptibility of BALB/cGnDu Mice to Transplantable Tumors, in vitro Transformed Cells, BK and SV40 Viruses, and Chemical Carcinogens

1982 • 3 citations

Life span and causes of death of albino rats after prolonged intermittent feeding with ethylenediaminetetraacetate

1974 • 2 citations

Influence of Age at Exposure on Some Persistent and Late Effects of Irradiation with Fast Neutrons

1968 • 1 citations

[Malignant neoplasms in the USSR in 1978].

1981 • 1 citations