Inhibitors of the Biosynthesis and Processing of N-Linked Oligosaccharide

Biological Applications of Ionophores

1976 • 1,829 citations

Purification and Properties of an Endo-β-N-acetylglucosaminidase from Streptomyces griseus

1974 • 870 citations

Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes

1975 • 863 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Comparative Aspects of Glycoprotein Structure

1976 • 767 citations

Biological Activity of Some Oxygenated Sterols

1978 • 570 citations

TUNICAMYCIN, A NEW ANTIBIOTIC. I

1971 • 535 citations

Synchronised transmembrane insertion and glycosylation of a nascent membrane protein

1977 • 529 citations

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

1982 • 463 citations

The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein

1978 • 421 citations

A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens

1979 • 416 citations

Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase

1979 • 411 citations

Plasma cell immunoglobulin secretion. Arrest is accompanied by alterations the golgi complex

1977 • 404 citations

Role of carbohydrates in protein secretion and turnover: Effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts

1978 • 391 citations

Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides.

1979 • 390 citations

Evidence for the participation of saccharide-lipids in the synthesis of the oligosaccharide chain of ovalbumin.

1977 • 375 citations

Structure and synthesis of nojirimycin

1968 • 366 citations

Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe

1981 • 365 citations

Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens

1980 • 365 citations

The specific site of tunicamycin inhibition in the formation of dolichol‐bound N‐acetylglucosamine derivatives

1976 • 362 citations

Mechanism of Action of Bacitracin: Complexation with Metal Ion and C ₅₅ -Isoprenyl Pyrophosphate

1971 • 354 citations

Castanospermine, a tetrahydroxylated alkaloid that inhibits β-glucosidase and β-glucocerebrosidase

1983 • 290 citations

Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.

1982 • 285 citations

The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides

1978 • 282 citations

Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells.

1977 • 277 citations

The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures.

1979 • 255 citations

Suppression of glycoprotein formation of Semliki Forest, influenza, and avian sarcoma virus by tunicamycin

1976 • 254 citations

Swainsonine: an inhibitor of glycoprotein processing.

1981 • 252 citations

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin

1983 • 251 citations

The Function of Saccharide-Lipids in Synthesis of Glycoproteins

1980 • 247 citations

The primary glycosylation defect in class E Thy-1-negative mutant mouse lymphoma cells is an inability to synthesize dolichol-P-mannose.

1980 • 238 citations

Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.

1979 • 228 citations

The tunicamycins — useful tools for studies on glycoproteins

1981 • 227 citations

Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct.

1976 • 218 citations

Inhibition of Biosynthesis of Polyisoprenol Sugars in Chick Embryo Microsomes by Tunicamycin

1975 • 218 citations

Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus.

1977 • 217 citations

Oligosaccharide chains are trimmed during synthesis of the envelope glycoprotein of vesicular stomatitis virus.

1978 • 210 citations

Vesicular stomatitis virus and sindbis virus glycoprotein transport to the cell surface is inhibited by ionophores

1980 • 198 citations

Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin

1978 • 195 citations

Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein

1978 • 187 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

EFFECT OF TUNICAMYCIN ON THE SYNTHESIS OF MACROMOLECULES IN CULTURES OF CHICK EMBRYO FIBROBLASTS INFECTED WITH NEWCASTLE DISEASE VIRUS

1971 • 185 citations

The Role of Lipid-Linked Saccharides in the Biosynthesis of Complex Carbohydrates

1979 • 182 citations

Effect of Tunicamycin on IgM, IgA, and IgG Secretion by Mouse Plasmacytoma Cells

1978 • 180 citations

Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.

1977 • 178 citations

Immunocytochemical localization of procollagen and fibronectin in human fibroblasts: effects of the monovalent ionophore, monensin.

1980 • 171 citations

Control of glycoprotein synthesis. Lectin-resistant mutant containing only one of two distinct N-acetylglucosaminyltransferase activities present in wild type Chinese hamster ovary cells.

1977 • 161 citations

Glucosidase-Inhibitoren aus Bazillen

1979 • 159 citations

Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts

1979 • 159 citations

Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.

1980 • 153 citations

LYSOSOMAL STORAGE IN SWAINSONA SPP. TOXICOSIS: AN INDUCED MANNOSIDOSIS

1978 • 152 citations

Immediate glycosylation of Sindbis virus membrane proteins

1977 • 150 citations

Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis

1978 • 148 citations

Monensin and FCCP inhibit the intracellular transport of alphavirus membrane glycoproteins

1980 • 143 citations

Purification and characterization of glucosidase II, an endoplasmic reticulum hydrolase involved in glycoprotein biosynthesis.

1982 • 138 citations

Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity.

1980 • 138 citations

Synthesis of the N-linked oligosaccharides of glycoproteins. Assembly of the lipid-linked precursor oligosaccharide and its relation to protein synthesis in vivo.

1980 • 137 citations

The use of bacitracin as an inhibitor of the degradation of thyrotropin releasing factor and luteinizing hormone releasing factor

1976 • 136 citations

Lysosomal alpha-D-mannosidase of rat liver. Purification and comparison with the golgi and cytosolic alpha-D-mannosidases

1978 • 135 citations

Localization of the enzyme system for glycosylation of proteins via the lipid-linked pathway in rough endoplasmic reticulum.

1977 • 129 citations

Arrangement of glucose residues in the lipid-linked oligosaccharide precursor of asparaginyl oligosaccharides.

1979 • 127 citations

Increase in the lipid intermediate pathway of protein glycosylation during hen oviduct differentiation.

1977 • 127 citations

Swainsonine prevents the processing of the oligosaccharide chains of influenza virus hemagglutinin.

1982 • 124 citations

A role for oligosaccharides in glycoprotein biosynthesis

1980 • 117 citations

N-Acetylglucosamine-1-phosphate transferase from hen oviduct: solubilization, characterization, and inhibition by tunicamycin

1979 • 114 citations

An example of enzyme hysteresis. The slow and tight interaction of some fully competitive inhibitors with small intestinal sucrase.

1981 • 112 citations

Carbohydrates of Influenza Virus. I. Glycopeptides Derived from Viral Glycoproteins After Labeling with Radioactive Sugars

1977 • 112 citations

Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures.

1979 • 112 citations

A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.

1982 • 110 citations

Interference with glycosylation of glycoproteins. Inhibition of formation of lipid-linked oligosaccharides in vivo

1979 • 108 citations

Inhibition of polyisoprenoid and glycoprotein biosynthesis causes abnormal embryonic development.

1979 • 107 citations

Relationship of glycosylation to de novo thyroid-stimulating hormone biosynthesis and secretion by mouse pituitary tumor cells.

1980 • 106 citations

Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.

1980 • 106 citations

Effect of 2-deoxy-d-glucose on the multiplication of semliki forest virus and the reversal of the block by mannose

1973 • 106 citations

Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides

1980 • 106 citations

Impairment of dolichyl saccharide synthesis and dolichol-mediated glycoprotein assembly in the aortic smooth muscle cell in culture by inhibitors of cholesterol biosynthesis

1978 • 106 citations

Holomycin and an antibiotic(MM 19290) related to tunicamycin, metabolites of Streptomyces clavuligerus.

1979 • 104 citations

Formation of 2-Deoxyglucose-Containing Lipid-Linked Oligosaccharides. Interference with Glycosylation of Glycoproteins

1978 • 103 citations

Amphomycin inhibition of mannose and GlcNAc incorporation into lipid-linked saccharides.

1978 • 102 citations

Structure of the peptide antibiotic amphomycin

1973 • 99 citations

Glycosylation of interferons. Effects of tunicamycin on human immune interferon

1978 • 98 citations

Glycoprotein nature of yeast alkaline phosphatase. Formation of active enzyme in the presence of tunicamycin.

1979 • 96 citations

Sugar Residues on Protein

1981 • 95 citations

Mammalian Glycosyltransferases

1980 • 93 citations

Effect of exogenous dolichyl monophosphate on a developmental change in mannosylphosphoryldolichol biosynthesis

1977 • 92 citations

Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.

1981 • 87 citations

Dolichyldiphosphoryloligosaccharide—protein oligosaccharyltransferase: Solubilization, purification, and properties

1980 • 82 citations

TUNICAMYCIN, A NEW ANTIBIOTIC. II

1971 • 81 citations

Modification of oligosaccharide- lipid synthesis and protein glycosylation in glucose-deprived cells

1980 • 78 citations

Spatial orientation of glycoproteins in membranes of rat liver rough microsomes. I. Localization of lectin-binding sites in microsomal membranes.

1978 • 78 citations

Glycopeptide components of influenza viral glycoproteins

1978 • 77 citations

Enzymatic excision of glucosyl units linked to the oligosaccharide chains of glycoproteins

1978 • 72 citations

Nonglycosylated mouse L cell interferon produced by the action of tunicamycin.

1978 • 71 citations

The Biosynthetic Pathway of the Asparagine-Linked Oligosaccharides of Glycoproteins

1982 • 69 citations

Studies on the biosynthesis of dolichyl phosphate: Evidence for the in vitro formation of 2,3-dehydrodolichyl phosphate

1977 • 67 citations

Purification and characterization of a phospholipid-dependent alpha-mannosidase from rabbit liver.

1981 • 67 citations

Effect of energy depletion on the glycosylation of a viral glycoprotein.

1981 • 66 citations

Amphomycin: effect of the lipopeptide antibiotic on the glycosylation and extraction of dolichyl monophosphate in calf brain membranes

1981 • 66 citations

Increased hepatic dolichol and dolichyl phosphate-mediated glycosylation in rats fed cholesterol

1981 • 63 citations

Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides.

1979 • 62 citations

Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins

1976 • 61 citations

Action of glycosidases on the saccharide moiety of the glucose—containing dolichyl diphosphate oligosaccharide

1978 • 59 citations

Surface Carbohydrate Alterations of Mutant Mammalian Cells Selected for Resistance to Plant Lectins

1980 • 58 citations

Fluoroglucose-Inhibition of Protein Glycosylation in vivo. Inhibition of Mannose and Glucose Incorporation into Lipid-Linked Oligosaccharides

1980 • 56 citations

Glycoprotein biosynthesis in myeloma cells. Characterization on nonglycosylated immunoglobulin light chain secreted in presence of 2-deoxy-D-glucose.

1977 • 55 citations

Neue Enzyminhibitoren aus Mikroorganismen

1979 • 54 citations

Glucosamine Itself Mediates Reversible Inhibition of Protein Glycosylation

1979 • 54 citations

Effect of swainsonine, an inhibitor of glycoprotein processing, on cultured mammalian cells

1983 • 54 citations

Studies on the regulation of glycoprotein biosynthesis. An investigation of the rate-limiting steps of dolichyl phosphate biosynthesis.

1979 • 53 citations

Fluorosugars inhibit biological properties of different enveloped viruses

1976 • 52 citations

Untersuchungen zum Wirkungsmechanismus glykosidspaltender Enzyme, VII. Funktionelle Gruppen am aktiven Zentrum einer α-Glucosidase ausSaccharomyces cerevisiae

1973 • 51 citations

Inhibition of lipid-linked saccharide synthesis: Comparison of tunicamycin, streptovirudin, and antibiotic 24010

1979 • 48 citations

Tunicamycin inhibits glycosylation of precursor polyprotein encoded by env gene of Rauscher murine leukemia virus

1979 • 46 citations

Formation of Dolichol Monophosphate 2‐Deoxy‐<scp>d</scp>‐glucose and Its Interference with the Glycosylation of Mannoproteins in Yeast

1976 • 45 citations

A glucosylated oligosaccharide lipid intermediate in calf brain. Evidence for the transfer of the oligosaccharide into membrane glycoprotein and subsequent removal of glucosyl residues.

1979 • 44 citations

The biosynthesis of oligosaccharide-lipids. Partial purification and characterization of mannosyltransferase II.

1981 • 43 citations

The Structure of Tunicamycin

1977 • 43 citations

Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography

1980 • 42 citations

Regulation of dolichol and of cholesterol biosynthesis in cholesterol-fed rabbits

1981 • 41 citations

Annual review of biochemistry

1980 • 41 citations

Transfer of mannose from GDP-mannose to lipid-linked oligosaccharide by soluble mannosyl transferase.

1980 • 39 citations

Properties of a soluble polyprenyl phosphate. UDP-D-N-acetylglucosamine N-acetylglucosamine-1-phosphate transferase.

1980 • 39 citations

AN ANTIBIOTIC 24010

1971 • 38 citations

Streptovirudins, new antibiotics with antibacterial and antiviral activity. II. Isolation, chemical characterization and biological activity of streptovirudins A1, A2, B1, B2, C1, C2, D1 and D2.

1975 • 38 citations

Recent Chemical Studies on Peptide Antibiotics from the Genus Bacillus

1978 • 36 citations

Tunicamycin does not block ovalbumin secretion in the oviduct

1978 • 36 citations

Effects of Gibberellic Acid and of Tunicamycin on Glycosyl‐Transferase Activities and on α‐Amylase Secretion in Barley

1979 • 35 citations

Processing of placental peptide hormones synthesized in lysates containing membranes derived from tunicamycin-treated ascites tumor cells.

1978 • 34 citations

The formation of lipid-linked oligosaccharides in Madin-Darby canine kidney cells. Changes in oligosaccharide profiles induced by glucosamine.

1982 • 33 citations

Selective cytotoxicity of tunicamycin for transformed cells

1979 • 31 citations

Inhibition of Sterol Biosynthesis by Bacitracin

1972 • 30 citations

Bacitracin Inhibits the Synthesis of Lipid-linked Saccharides and Glycoproteins in Plants

1978 • 30 citations

Deoxyglucose inhibition of protein glycosylation: Effects of nucleotide deoxysugars on the formation of glucosylated lipid intermediates

1981 • 30 citations

Effect of monensin on Mason-Pfizer monkey virus glycoprotein synthesis

1982 • 30 citations

Effects of monensin on morphogenesis and infectivity of Friend murine leukemia virus

1982 • 29 citations

Synthesis of the glycoprotein hormone .alpha. subunit and placental alkaline phosphatase by HeLa cells: effect of tunicamycin, 2-deoxyglucose, and sodium butyrate

1981 • 28 citations

Effect of bacitracin on the biosynthesis of dolichol derivatives in calf pancreas microsomes

1977 • 28 citations

The effect of showdomycin on glycolipid formation. Inhibition of glucosyl-phosphoryl-dolichol in aorta and stimulation of glucosylceramide in yeast.

1979 • 26 citations

Glycosylation of endogenous protein(s) of the rough and smooth microsomes by a lipid sugar intermediate

1977 • 24 citations

Secretion of proteins from liver cells is suppressed by the proteinase inhibitor N‐α‐tosyl‐L‐lysyl chloromethane, but not by tunicamycin, an inhibitor of glycosylation

1979 • 24 citations

Inhibition of lipid-linked saccharide synthesis by bacitracin

1978 • 24 citations

Studies on bacterial cell wall inhibitors. X. Properties of phospho-N-acetylmuramoyl-pentapeptide-transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin.

1982 • 22 citations

Glycolipid formation in Volvox carteri f. nagariensis

1981 • 21 citations

Nojirimycin-A potent inhibitor of purified lysosomal alpha-glucosidase from human liver

1982 • 21 citations

Inhibitory Effects of Tunicamycin and 2-Deoxyglucose on Thyroglobulin Synthesis

2005 • 20 citations

The effect of bacitracin and Ca++ on the formation of polyprenylpyrophosphates and their incorporation into ubiquinone precursors in mammalian and bacterial systems

1972 • 19 citations

Inhibition of Lipid‐Linked Mannose and Mannoprotein Synthesis in Yeast by Diumycin in vitro

1980 • 17 citations

The effect of tsushimycin on the synthesis of lipid-linked saccharides in aorta

1981 • 17 citations

The effect of bacitracin on the formation of polyprenol derivatives in yeast membrane vesicles

1978 • 16 citations

THE DIUMYCINS

1969 • 16 citations

Streptovirudins of series I and II: chemical and biological properties

1981 • 16 citations

Glycosylation of endogenous proteins through dolichol derivatives in reticulocyte plasma membranes

1977 • 14 citations

Inhibition of Peptidoglycan Synthesis by the Antibiotic Diumycin A

1972 • 12 citations

The Structure of Tunicaminyl Uracil, a Degradation Product of Tunicamycin

1977 • 11 citations

INHIBITION OF CELL WALL SYNTHESIS BY THE ANTIBIOTICS DIUMYCIN AND JANIEMYCIN

1974 • 11 citations

Antibiotics affecting bacterial wall synthesis

1980 • 9 citations

Isolation and Structures of Components of Tunicamycin

1980 • 8 citations