Gastric cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer

2006 • 5,651 citations

Helicobacter pyloriInfection and the Development of Gastric Cancer

2001 • 4,276 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Chemoradiotherapy after Surgery Compared with Surgery Alone for Adenocarcinoma of the Stomach or Gastroesophageal Junction

2001 • 3,402 citations

Gene Silencing in Cancer in Association with Promoter Hypermethylation

2003 • 3,332 citations

Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World

2006 • 3,314 citations

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

1992 • 3,047 citations

Surgeon Volume and Operative Mortality in the United States

2003 • 2,846 citations

Global cancer statistics in the year 2000

2001 • 2,471 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

Adjuvant Chemotherapy for Gastric Cancer with S-1, an Oral Fluoropyrimidine

2007 • 2,333 citations

Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer

2008 • 2,152 citations

Japanese Classification of Gastric Carcinoma – 2nd English Edition –

1998 • 2,118 citations

Epidemiology of gastric cancer

2006 • 2,069 citations

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

2003 • 2,056 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii

1991 • 1,769 citations

Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers

2000 • 1,749 citations

Is Volume Related to Outcome in Health Care? A Systematic Review and Methodologic Critique of the Literature

2002 • 1,659 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial

1999 • 1,361 citations

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial

2008 • 1,176 citations

Chemotherapy in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis Based on Aggregate Data

2006 • 1,146 citations

Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts

2001 • 1,019 citations

D2 Lymphadenectomy Alone or with Para-aortic Nodal Dissection for Gastric Cancer

2008 • 971 citations

Assembly of microarrays for genome-wide measurement of DNA copy number

2001 • 948 citations

Extended Lymph Node Dissection for Gastric Cancer: Who May Benefit? Final Results of the Randomized Dutch Gastric Cancer Group Trial

2004 • 881 citations

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

2008 • 847 citations

Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer

1997 • 843 citations

Genome instability: a mechanistic view of its causes and consequences

2008 • 742 citations

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

1995 • 668 citations

Endoscopic submucosal dissection of early gastric cancer

2006 • 652 citations

Nodal dissection for patients with gastric cancer: a randomised controlled trial

2006 • 616 citations

Hospital Volume and Late Survival After Cancer Surgery

2007 • 608 citations

Gastric cancer treatment guidelines in Japan

2002 • 561 citations

Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials.

1993 • 560 citations

Treatment of locally unresectable cancer of the stomach and pancreas: a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil--an Eastern Cooperative Oncology Group study.

1985 • 522 citations

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

1998 • 512 citations

Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy

2000 • 508 citations

Adenocarcinoma of the stomach: Areas of failure in a re-operation series (second or symptomatic look) clinicopathologic correlation and implications for adjuvant therapy

1982 • 492 citations

Diet and the risk of gastric cancer: review of epidemiological evidence

2007 • 476 citations

Smoking and gastric cancer: systematic review and meta-analysis of cohort studies

2008 • 475 citations

Subtotal Versus Total Gastrectomy for Gastric Cancer

1999 • 424 citations

Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: revisiting a meta-analysis of randomised trials

1999 • 416 citations

A multicenter retrospective study of endoscopic resection for early gastric cancer

2006 • 402 citations

Randomized comparison of R1 and R2 gastrectomy for gastric carcinoma

1988 • 397 citations

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

1999 • 369 citations

Phase II Trial of Preoperative Chemoradiation in Patients With Localized Gastric Adenocarcinoma (RTOG 9904): Quality of Combined Modality Therapy and Pathologic Response

2006 • 368 citations

A Prospective Randomized Trial Comparing R1 Subtotal Gastrectomy with R3 Total Gastrectomy for Antral Cancer

1994 • 366 citations

Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

2004 • 366 citations

Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: A meta-analysis of published randomised trials

2000 • 362 citations

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.

1996 • 347 citations

A Systematic Review and Meta-analysis of the Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Gastric Cancer

2007 • 345 citations

Multi-Institutional Trial of Preoperative Chemoradiotherapy in Patients With Potentially Resectable Gastric Carcinoma

2004 • 331 citations

Imaging in Local Staging of Gastric Cancer: A Systematic Review

2007 • 304 citations

The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up

1994 • 296 citations

An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach

2005 • 292 citations

Total Versus Subtotal Gastrectomy for Adenocarcinoma of the Gastric Antrum

1989 • 292 citations

E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer

1999 • 286 citations

Paclitaxel-Based Chemoradiotherapy in Localized Gastric Carcinoma: Degree of Pathologic Response and Not Clinical Parameters Dictated Patient Outcome

2005 • 276 citations

Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors

2008 • 269 citations

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

2006 • 267 citations

Final results of a randomized trial comparing preoperative 5-fluorouracil (F)/cisplatin (P) to surgery alone in adenocarcinoma of stomach and lower esophagus (ASLE): FNLCC ACCORD07-FFCD 9703 trial

2007 • 263 citations

Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (AGC) — report on 370 patients

1998 • 250 citations

A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors

2006 • 249 citations

Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer

2006 • 243 citations

Geographic Differences in Gastric Cancer Incidence Can be Explained by Differences between Helicobacter pylori Strains

2008 • 238 citations

Gastric Cancer Staging at Multi–Detector Row CT Gastrography: Comparison of Transverse and Volumetric CT Scanning

2005 • 237 citations

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

2001 • 224 citations

Evaluation of 18F‐2‐deoxy‐2‐fluoro‐<scp>d</scp>‐glucose Positron Emission Tomography for Gastric Cancer

2004 • 222 citations

Combined 5-fluorouracil and radiation therapy as a surgical adjuvant for poor prognosis gastric carcinoma.

1984 • 217 citations

BAC to the future! or oligonucleotides: a perspective for micro array comparative genomic hybridization (array CGH)

2006 • 215 citations

Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer

2008 • 211 citations

Surgical treatment variation in a prospective, randomized trial of chemoradiotherapy in gastric cancer: The effect of undertreatment

2002 • 209 citations

A comparison of combination chemotherapy and combined modality therapy for locally advanced gastric carcinoma

1982 • 206 citations

Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial

2004 • 183 citations

Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization

1999 • 180 citations

Prognostic Significance of CpG Island Methylator Phenotype and Microsatellite Instability in Gastric Carcinoma

2005 • 179 citations

Resectable gastric carcinoma. An evaluation of preoperative and postoperative chemotherapy

1991 • 170 citations

Chemotherapy for metastatic gastric cancer: past, present, and future

2008 • 170 citations

Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation

2002 • 167 citations

Rate of detection of lymph node metastasis is correlated with the depth of submucosal invasion in early stage gastric carcinoma

1999 • 166 citations

Patterns of genomic instability in gastric cancer: clinical implications and perspectives

2006 • 158 citations

Nutrition and gastric cancer risk: an update

2008 • 144 citations

Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers

2006 • 138 citations

Cohort study in South and West England of the influence of specialization on the management and outcome of patients with oesophageal and gastric cancers

2002 • 138 citations

Early Metabolic Response Evaluation by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Allows In vivo Testing of Chemosensitivity in Gastric Cancer: Long-term Results of a Prospective Study

2008 • 138 citations

Chemotherapy of advanced gastric cancer

2007 • 132 citations

Laparoscopic gastrectomy with lymph node dissection for gastric cancer

2006 • 131 citations

EMR for early gastric cancer in Korea: a multicenter retrospective study

2007 • 131 citations

Mechanisms and sequelae of E‐cadherin silencing in hereditary diffuse gastric cancer

2008 • 130 citations

Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study

2003 • 129 citations

CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC‐EURGAST study

2006 • 127 citations

Genomic profiling of gastric cancer predicts lymph node status and survival

2003 • 125 citations

Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer

2006 • 118 citations

Effect of microscopic resection line disease on gastric cancer survival

1999 • 118 citations

Computer analysis in making preoperative decisions: A rational approach to lymph node dissection in gastric cancer patients

1989 • 115 citations

The role of staging laparoscopy in oesophagogastric cancers

2007 • 113 citations

IMRT for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step-and-shoot and an arc therapy approach

2004 • 110 citations

Randomized Controlled Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: Japan Clinical Oncology Group Study JCOG 0110-MF

2002 • 108 citations

Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study

2007 • 106 citations

Optimal Locoregional Treatment in Gastric Cancer

2005 • 99 citations

Prognostic value of resection-line involvement in patients undergoing curative resections for gastric cancer

1996 • 97 citations

IMRT for adjuvant radiation in gastric cancer: A preferred plan?

2005 • 97 citations

Genetic alterations in 102 primary gastric cancers by comparative genomic hybridization: gain of 20q and loss of 18q are associated with tumor progression

2004 • 96 citations

Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer

2006 • 92 citations

Randomized trial of intraoperative radiotherapy in carcinoma of the stomach

1993 • 90 citations

Current status of minimal access surgery for gastric cancer

2007 • 88 citations

Ignoring small lymph nodes can be a major cause of staging error in gastric cancer

1998 • 86 citations

No survival benefit from combined pancreaticosplenectomy and total gastrectomy for gastric cancer

1999 • 86 citations

The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data

2007 • 83 citations

Hospital volume does not influence long-term survival of patients undergoing surgery for oesophageal or gastric cancer

2007 • 83 citations

Citrus fruit intake and stomach cancer risk: a quantitative systematic review

2008 • 83 citations

Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes

2000 • 82 citations

Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence.

2002 • 80 citations

Low Maruyama Index Surgery for Gastric Cancer: Blinded Reanalysis of the Dutch D1‐D2 Trial

2005 • 80 citations

Microsatellite Instability Is a Predictive Marker for Survival Benefit from Adjuvant Chemotherapy in a Population-Based Series of Stage III Colorectal Carcinoma

2001 • 80 citations

Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma.

2003 • 79 citations

Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker

2008 • 76 citations

Combined GADD45A and Thymidine Phosphorylase Expression Levels Predict Response and Survival of Neoadjuvant-Treated Gastric Cancer Patients

2005 • 73 citations

Lack of Benefit of Combined Pancreaticosplenectomy in D2 Resection for Proximal‐Third Gastric Carcinoma

1997 • 73 citations

Gastric cancers in young and elderly patients show different genomic profiles

2006 • 70 citations

Interim Results of Sentinel Node Biopsy during Laparoscopic Gastrectomy: Possible Role in Function‐Preserving Surgery for Early Cancer

2006 • 68 citations

Laparoscopy significantly improves the perceived preoperative stage of gastric cancer

2003 • 67 citations

Hospital volume and post-operative mortality after resection for gastric cancer

2002 • 66 citations

Adjuvant radiotherapy and chemotherapy in resectable gastric cancer. A randomized trial of the gastro-intestinal tract cancer cooperative group of the EORTC.

1989 • 65 citations

Epidermal growth factor receptor structural alterations in gastric cancer

2008 • 65 citations

Tumor Microsatellite Instability in Early Onset Gastric Cancer

2005 • 64 citations

Genetic Alterations of Gastric Cancer

2000 • 64 citations

Concentrated preoperative radiotherapy for resectable gastric cancer: 20‐years follow‐up of a randomized trial

2002 • 63 citations

The influence of surgical volume on hospital mortality and 5-year survival for carcinoma of the oesophagus and gastric cardia.

2005 • 56 citations

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma

2008 • 55 citations

Cancer Mortality among Chinese Migrants: A Review

1995 • 54 citations

Sentinel node biopsy for cT1 and cT2a gastric cancer

2005 • 52 citations

The influence of case load and the extent of resection on the quality of treatment outcome in gastric cancer

2005 • 52 citations

Adjuvant Therapy for Resected Gastric Cancer—Rapid, Yet Incomplete Adoption Following Results of Intergroup 0116 Trial

2007 • 51 citations

Review article: Helicobacter pylori eradication for the prevention of gastric cancer

2007 • 51 citations

MRE11 expression is impaired in gastric cancer with microsatellite instability

2004 • 51 citations

Validation of staging systems for gastric cancer

2008 • 49 citations

Procedure volume of gastric cancer resections versus 5-year survival

2007 • 47 citations

Sentinel node mapping during laparoscopic distal gastrectomy for gastric cancer

2007 • 46 citations

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas

2003 • 46 citations

The concept of locally advanced gastric cancer: Effect of treatment on outcome

1990 • 46 citations

The Survival Impact of the Intergroup 0116 Trial on Patients With Gastric Cancer

2008 • 45 citations

Adjuvant chemoradiation using 5-fluorouracil/folinic acid/cisplatin with or without paclitaxel and radiation in patients with completely resected high-risk gastric cancer: two cooperative phase II studies of the AIO/ARO/ACO

2005 • 44 citations

The tolerance and efficacy of preoperative chemoradiotherapy followed by gastrectomy in operable gastric cancer, a phase II study

2007 • 44 citations

Barrett's adenocarcinomas resemble adenocarcinomas of the gastric cardia in terms of chromosomal copy number changes, but relate to squamous cell carcinomas of the distal oesophagus with respect to the presence of high‐level amplifications

2002 • 41 citations

A Phase I–II Study of Postoperative Capecitabine-Based Chemoradiotherapy in Gastric Cancer

2007 • 40 citations

Extended versus limited lymph nodes dissection technique for adenocarcinoma of the stomach

2003 • 40 citations

Neoadjuvant radiochemotherapy for locally advanced gastric cancer: Long-term results of a phase I trial

2005 • 38 citations

Results of irradiation or chemoirradiation for primary unresectable, locally recurrent, or grossly incomplete resection of gastric adenocarcinoma

2000 • 38 citations

Helicobacter pylori-related and -non-related gastric cancers do not differ with respect to chromosomal aberrations

2000 • 37 citations

Morbidity and mortality of early postoperative intraperitoneal chemotherapy as adjuvant therapy for gastric cancer.

1998 • 36 citations

Improved regional control and survival with “low Maruyama Index” surgery in gastric cancer: autopsy findings from the Dutch D1-D2 Trial

2007 • 35 citations

Clinical value of multidetector row computed tomography in detecting lymph node metastasis of early gastric cancer

2005 • 33 citations

Endoscopic ultrasonography-detected low-volume ascites as a predictor of inoperability for oesophagogastric cancer

2008 • 32 citations

Presence of High-Level DNA Copy Number Gains in Gastric Carcinoma and Severely Dysplastic Adenomas but Not in Moderately Dysplastic Adenomas

1998 • 32 citations

Phase II Study of Chemoradiotherapy With S-1 and Low-Dose Cisplatin for Inoperable Advanced Gastric Cancer

2007 • 32 citations

A novel STK11 germline mutation in two siblings with Peutz–Jeghers syndrome complicated by primary gastric cancer

2004 • 31 citations

Loss of heterozygosity and microsatellite instability as predictive markers for neoadjuvant treatment in gastric carcinoma.

2000 • 31 citations

Value of computed tomography in addition to ultrasound for preoperative staging of gastric cancer

2002 • 30 citations

Postoperative chemoradiotherapy in gastric cancer – a phase I/II dose-finding study of radiotherapy with dose escalation of cisplatin and capecitabine chemotherapy

2007 • 28 citations

Long-Term Results After Intraoperative Radiation Therapy for Gastric Cancer

2008 • 21 citations

Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy

2008 • 20 citations

Chemoradiation Therapy for Potentially Resectable Gastric Cancer: Clinical Outcomes Among Patients Who Do Not Undergo Planned Surgery

2008 • 16 citations

Gastric cancer in Europe

2008 • 13 citations

A comparative study of pancreatectomy and pancreas-preserving gastrectomy in advanced gastric carcinomas.

2004 • 10 citations