Microsatellite Instability Is a Predictive Marker for Survival Benefit from Adjuvant Chemotherapy in a Population-Based Series of Stage III Colorectal Carcinoma

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma

1990 • 2,226 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

2000 • 1,352 citations

Fluorouracil plus Levamisole as Effective Adjuvant Therapy after Resection of Stage III Colon Carcinoma: A Final Report

1995 • 907 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer

2000 • 556 citations

Morphology of sporadic colorectal cancer with DNA replication errors

1998 • 465 citations

Mismatch repair proficiency and in vitro response to 5-fluorouracil

1999 • 416 citations

Microsatellite Instability and 8p Allelic Imbalance in Stage B2 and C Colorectal Cancers

1999 • 375 citations

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

2000 • 352 citations

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1998 • 338 citations

Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.

1996 • 252 citations

Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites

1998 • 243 citations

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.

1998 • 213 citations

Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy.

2001 • 186 citations

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

1997 • 184 citations

Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor

1999 • 104 citations

Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis

1999 • 82 citations

Five-year Results of a Randomized Controlled Trial of Adjuvant Chemotherapy for Curatively Resected Colorectal Carcinoma

1995 • 40 citations

Rapid and nonisotopic SSCP-based analysis of the BAT-26 mononucleotide repeat for identification of the replication error phenotype in human cancers

1998 • 25 citations

Microsatellite instability in young patients with colorectal cancer

1998 • 22 citations