Therapy of chronic myelogenous leukemia with bone marrow transplantation

Bone Marrow Transplant

2001 • 3,479 citations

Bone marrow transplant

1989 • 3,423 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

1986 • 1,453 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 989 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 919 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings

1985 • 844 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

Effect of HLA Compatibility on Engraftment of Bone Marrow Transplants in Patients with Leukemia or Lymphoma

1989 • 693 citations

Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon Alpha_Ain Chronic Myelogenous Leukemia

1986 • 675 citations

Marrow Transplantation for Acute Nonlymphoblastic Leukemia in First Remission

1979 • 655 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen

1987 • 540 citations

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

1984 • 436 citations

Bone Marrow Transplantation for Patients with Chronic Myeloid Leukemia

1986 • 422 citations

Bone marrow transplant.

1985 • 404 citations

Interstitial Pneumonitis After Bone Marrow Transplantation

1986 • 381 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BREASTFEEDING IN DEVELOPING COUNTRIES

1981 • 374 citations

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1986 • 344 citations

Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia

1983 • 337 citations

Long-Term Marrow Culture Reveals Chromosomally Normal Hematopoietic Progenitor Cells in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1983 • 335 citations

Clinical investigation of human alpha interferon in chronic myelogenous leukemia

1987 • 332 citations

Evidence for a multistep pathogenesis of chronic myelogenous leukemia

1981 • 331 citations

Allogenic bone marrow transplantation: current status and future directions

1983 • 309 citations

Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse.

1986 • 298 citations

Transplantation of Marrow from an Unrelated Donor to a Patient with Acute Leukemia

1980 • 284 citations

HOW DOES BONE-MARROW TRANSPLANTATION CURE LEUKAEMIA?

1984 • 277 citations

Treatment of Donor Bone Marrow with Monoclonal Anti-T-Cell Antibody and Complement for the Prevention of Graft-Versus-Host Disease

1986 • 275 citations

ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKAEMIA

1984 • 265 citations

Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987 Jun;69(6):1789]

1987 • 248 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 245 citations

New Inventions

1966 • 229 citations

Terminal Transferase as a Predictor of Initial Responsiveness to Vincristine and Prednisone in Blastic Chronic Myelogenous Leukemia

1978 • 229 citations

Lymphoid Blast Crises of Chronic Myelogenous Leukemia Represent Stages in the Development of B-Cell Precursors

1983 • 215 citations

Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival

1985 • 214 citations

INSENSITIVITY OF RESPIRATORY CENTRE TO CARBON DIOXIDE IN THE ENGA PEOPLE OF NEW GUINEA

1971 • 212 citations

L-tryptophan verses E.C.T.

1970 • 201 citations

Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft‐versus‐leukaemia effect

1988 • 201 citations

Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol)

1979 • 194 citations

Ph1-Positive Leukaemia, Including Chronic Myelogenous Leukaemia

1980 • 191 citations

T CELL DEPLETION WITH CAMPATH-1 IN ALLOGENEIC BONE MARROW TRANSPLANTATION

1988 • 189 citations

Reconstitution in Severe Combined Immunodeficiency by Transplantation of Marrow from an Unrelated Donor

1977 • 186 citations

Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

1988 • 184 citations

Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987 Jun;69(6):1789]

1987 • 176 citations

Disappearance of pH¹-Positive Cells in Four Patients with Chronic Granulocytic Leukemia after Chemotherapy, Irradiation and Marrow Transplantation from an Identical Twin

1979 • 161 citations

TREATMENT OF CHRONIC GRANULOCYTIC LEUKAEMIA IN CHRONIC PHASE BY ALLOGENEIC MARROW TRANSPLANTATION

1982 • 161 citations

Growth characteristics of leukemic and normal hematopoietic cells in Ph' + chronic myelogenous leukemia and effects of intensive treatment

1982 • 159 citations

Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia

1986 • 158 citations

Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia

1971 • 158 citations

Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity

1979 • 157 citations

Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol)

1979 • 156 citations

PROBABILITY OF FINDING HLA-MATCHED UNRELATED MARROW DONORS

1988 • 149 citations

Human Leukemic Cells: In vitro Growth of Colonies Containing the Philadelphia (Ph ¹ ) Chromosome

1971 • 148 citations

Characteristics of the Terminal Phase of Chronic Granulocytic Leukemia

1968 • 144 citations

Treatment of Chronic Granulocytic Leukemia with Chemoradiotherapy and Transplantation of Marrow from Identical Twins

1982 • 137 citations

MARROW TRANSPLANTATION FOR PATIENTS IN THE CHRONIC PHASE OF CHRONIC GRANULOCYTIC LEUKAEMIA

1982 • 134 citations

Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia.

1981 • 131 citations

Blast crisis of chronic granulocytic leukemia

1977 • 127 citations

Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation

1985 • 118 citations

Collection, manipulation and freezing of haemopoietic stem cells

1986 • 118 citations

Prognostic significance of additional cytogenetic abnormalities at diagnosis of Philadelphia chromosome-positive chronic granulocytic leukemia

1988 • 117 citations

Staging of Chronic Myeloid Leukaemia

1981 • 115 citations

Origin of Chronic Myelocytic Leukemia in a Precursor of Pre-B Lymphocytes

1979 • 113 citations

Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia.

1985 • 111 citations

Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction

1988 • 109 citations

RECONSTITUTION OF HAEMOPOIETIC SYSTEM WITH AUTOLOGOUS MARROW TAKEN DURING RELAPSE OF ACUTE MYELOBLASTIC LEUKAEMIA AND GROWN IN LONG-TERM CULTURE

1986 • 107 citations

Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase

1988 • 107 citations

Prognostic significance of additional cytogenetic abnormalities at diagnosis of Philadelphia chromosome-positive chronic granulocytic leukemia

1988 • 105 citations

Bone marrow transplantation: Current controversies

1988 • 104 citations

Collection, Cryopreservation and Subsequent Viability of Haemopoietic Stem Cells Intended for Treatment of Chronic Granulocytic Leukaemia in Blast‐Cell Transformation

1978 • 104 citations

The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]

1988 • 96 citations

Unfavorable Signs in Patients with Chronic Myelocytic Leukemia

1972 • 96 citations

Preliminary Observations on the Therapy of the Myeloid Blast Phase of Chronic Granulocytic Leukemia with Plicamycin and Hydroxyurea

1986 • 94 citations

METAMORPHOSIS OF CHRONIC GRANULOCYTIC LEUKAEMIA: DIAGNOSIS, CLASSIFICATION, AND MANAGEMENT

1979 • 92 citations

Therapy of chronic myelogenous leukemia with recombinant interferon- gamma

1987 • 91 citations

Chemotherapy and autografting for chronic granulocytic leukaemia in transformation: probable prolongation of survival for some patients

1984 • 87 citations

Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction

1988 • 86 citations

Recurrence of Ph′-Positive Leukemia in Donor Cells after Marrow Transplantation for Chronic Granulocytic Leukemia

1984 • 85 citations

Adverse effect of severe marrow fibrosis on hematologic recovery after chemoradiotherapy and allogeneic bone marrow transplantation

1986 • 83 citations

Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow.

1978 • 82 citations

Combination chemotherapy for terminal-phase chronic granulocytic leukemia: cancer and leukemia group B studies

1980 • 79 citations

HLA-identical marrow transplantation during accelerated-phase chronic myelogenous leukemia: analysis of survival and remission duration

1988 • 78 citations

Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors.

1982 • 75 citations

The use of unrelated bone marrow donors in the treatment of patients with chronic myelogenous leukemia: experience of four marrow transplant centers.

1989 • 73 citations

SUCCESSFUL ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR PATIENTS IN THE ACCELERATED PHASE OF CHRONIC GRANULOCYTIC LEUKAEMIA

1982 • 72 citations

Prognostic features at diagnosis of chronic myelocytic leukemia

1981 • 71 citations

Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia

1979 • 69 citations

Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase

1982 • 68 citations

Therapy of chronic myelogenous leukemia with allogeneic bone marrow transplantation.

1987 • 64 citations

Bone marrow transplantation for acute myelosclerosis

1981 • 64 citations

Unrelated donor bone marrow transplantation therapy for chronic myelogenous leukemia

1987 • 64 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 63 citations

Allogeneic bone marrow transplantation for chronic granulocytic leukemia.

1981 • 60 citations

Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation.

1978 • 59 citations

T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia.

1985 • 59 citations

The location of breakpoints within the breakpoint cluster region (bcr) of chromosome 22 in chronic myeloid leukemia.

1988 • 58 citations

Cytogenetic studies of early myeloid progenitor compartments in Ph¹‐positive chronic myeloid leukaemia (CML) I. PERSISTENCE OF Ph¹‐NEGATIVE COMMITTED PROGENITORS THAT ARE SUPPRESSED FROM DIFFERENTIATING IN VIVO

1984 • 58 citations

Buffy coat autografts for patients with chronic granulocytic leukaemia in transformation

1981 • 56 citations

Clinical and prognostic features of patients with philadelphia chromosome-positive chronic myelogenous leukemia and extramedullary disease

1987 • 56 citations

Graft-versus-leukemia in man and animal models

1981 • 56 citations

Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients.

1987 • 55 citations

Treatment of blastic transformation of chronic granulocytic leukemia by high dose cyclophosphamide, total body irradiation and infusion of cryopreserved autologous marrow.

1974 • 55 citations

Reversal of acute ("malignant") myelosclerosis by allogeneic bone marrow transplantation

1982 • 54 citations

BONE MARROW TRANSPLANTATION FOR SEVERE APLASTIC ANEMIA USING A PHENOTYPICALLY HLA-IDENTICAL, SBCOMPATIBLE UNRELATED DONOR

1983 • 53 citations

Allogeneic marrow grafting with partially mismatched, unrelated marrow donors

1988 • 53 citations

Bone marrow transplantation for chronic myeloid leukemia.

1984 • 48 citations

Leukaemic transformation of engrafted bone marrow cells

1985 • 48 citations

EFFECT OF SPLENECTOMY BEFORE BONE-MARROW TRANSPLANTATION ON SURVIVAL IN CHRONIC GRANULOCYTIC LEUKAEMIA

1985 • 47 citations

Prevention of graft-versus-host disease by ex vivo T cell depletion: reduction in graft failure with augmented total body irradiation.

1988 • 47 citations

The role of T-cells in preventing relapse in chronic myelogenous leukemia.

1987 • 47 citations

Effect of recombinant gamma interferon on chronic myelogenous leukemia bone marrow progenitors.

1987 • 46 citations

Technical modifications in hyperfractionated total body irradiation for T-lymphocyte deplete bone marrow transplant

1989 • 45 citations

Use of minisatellite DNA probes for recognition and characterization of relapse after allogeneic bone marrow transplantation

1988 • 45 citations

Molecular abnormalities of bcr and c-abl in chronic myelogenous leukemia associated with a long chronic phase

1988 • 42 citations

Suppression of clonal evolution in two chronic myelogenous leukaemia patients treated with leucocyte interferon

1985 • 41 citations

The effects of splenectomy on engraftment and platelet transfusion requirements in patients with chronic myelogenous leukemia undergoing marrow transplantation

1986 • 41 citations

Bone Marrow Transplantation

1987 • 41 citations

Reversal of marrow fibrosis in acute megakaryoblastic leukaemia after remission‐induction and consolidation chemotherapy followed by bone marrow transplantation

1983 • 41 citations

Competition between recipient and donor cells after bone marrow transplantation for chronic myeloid leukaemia

1988 • 40 citations

Allogeneic marrow transplantation for chronic granulocytic leukemia

1982 • 37 citations

Haematological reconstitution and severity of graft‐versus‐host disease after bone marrow transplantation for chronic granulocytic leukaemia: the influence of previous splenectomy

1984 • 33 citations

Prognostic significance of cytogenetic abnormalities in patients with chronic myelogenous leukemia.

1988 • 32 citations

Therapeutic and prognostic value of initial chromosomal findings at the blastic phase of Ph1-positive chronic myeloid leukemia

1983 • 32 citations

Cytogenetic conversion following allogeneic bone marrow transplantation for advanced chronic myelogenous leukemia

1981 • 31 citations

Competition between recipient and donor cells after bone marrow transplantation for chronic myeloid leukaemia

1988 • 30 citations

In vitro restoration of polyclonal hematopoiesis in a chronic myelogenous leukemia after in vitro treatment with 4- hydroperoxycyclophosphamide

1985 • 29 citations

Allogeneic bone marrow transplantation as treatment for accelerating chronic myelogenous leukemia

1984 • 29 citations

Relapse after allogeneic bone marrow transplantation for Philadelphia chromosome positive chronic myeloid leukemia: cytogenetic analysis of 24 patients.

1988 • 28 citations

Reversal of severe bone marrow fibrosis and osteosclerosis following allogeneic bone marrow transplantation for chronic granulocytic leukaemia

1982 • 27 citations

PREVENTION OF GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIA BY T-CELL DEPLETION INVITRO PRIOR TO TRANSPLANTATION

1985 • 27 citations

Haematological Reconstitution after Autografting for Chronic Granulocytic Leukaemia in Transformation: the Influence of Previous Splenectomy

1980 • 26 citations

Variables influencing the timing of marrow transplantation in patients with chronic myelogenous leukemia

1986 • 23 citations

CD4+ T cells appear capable of initiating graft-versus-host disease across non-major histocompatibility complex (MHC) barriers in man.

1987 • 23 citations

The reversal of myelofibrosis associated with chronic myelogenous leukemia after allogeneic bone marrow transplantation.

1983 • 22 citations

Current status of blastic transformation in chronic myelogenous leukemia

1978 • 20 citations

Prospective confirmation of a prognostic classification for Ph + chronic myeloid leukaemia

1988 • 20 citations

Ph1negative haematological chimaerism after marrow transplantation in Ph1positive chronic granulocytic leukaemia

1986 • 19 citations

Irradiated donor buffy coat following T cell-depleted bone marrow transplants.

1988 • 19 citations

Competitive survival/proliferation of normal and Ph¹‐positive haemopoietic cells

1986 • 15 citations

Prognostic assessment of various parameters in chronic myeloid leukemia

1986 • 15 citations

Molecular analysis of relapse in chronic myeloid leukemia after allogeneic bone marrow transplantation

1987 • 14 citations

Preliminary characterization of functional residual host-type T lymphocytes following conditioning for allogeneic HLA-matched bone marrow transplantation (BMT).

1988 • 12 citations

Loss of myeloid differentiation antigens precedes blastic transformation in chronic myelogenous leukemia

1987 • 12 citations

Marrow transplantation for stable-phase chronic granulocytic leukemia.

1984 • 11 citations

Use of the BCR probe to demonstrate extramedullary recurrence of CGL with a T cell lymphoid phenotype following bone marrow transplantation.

1988 • 10 citations

Immunoglobulin and T-cell receptor gene rearrangement in blast crisis of chronic myelocytic leukemia.

1988 • 9 citations

Autologous marrow transplantation for patients with chronic myeloid leukemia in accelerated or blastic phase: report of 14 cases.

1986 • 9 citations

Upper and lower time limits in the decision to recommend marrow transplantation for patients with chronic myelogenous leukaemia

1988 • 9 citations

Bone marrow transplantation for chronic myeloid leukaemia

1987 • 8 citations

TRIPLE CHIMAERISM AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION FOR PHILADELPHIA CHROMOSOME POSITIVE CHRONIC GRANULOCYTIC LEUKAEMIA

1987 • 5 citations

High-dose chemotherapy and autologous stem cell infusion in patients with chronic myelogenous leukaemia in early phase of the disease

1988 • 4 citations

Deleted Work

1955 • 0 citations