TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry

1996 • 484 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

1984 • 392 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Identification of a common T/natural killer cell progenitor in human fetal thymus.

1994 • 280 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Optimization of Fibronectin-Assisted Retroviral Gene Transfer into Human CD34⁺Hematopoietic Cells

1997 • 215 citations

Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects

1991 • 214 citations

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

1996 • 200 citations

Deletion of the human T-cell receptor δ-gene by a site-specific recombination

1988 • 179 citations

Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44⁺CD25⁺Pro-T thymocytes

1998 • 169 citations

Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development.

1993 • 165 citations

Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia

1993 • 136 citations

Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells.

1997 • 132 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate.

1993 • 120 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: recommendations for optimal results.

1993 • 106 citations

The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44.

1995 • 101 citations

Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.

1995 • 97 citations

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

1988 • 93 citations

The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation

1992 • 77 citations

Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture.

1994 • 74 citations

Production and Characterization of Functional Domains of Human Fibronectin Expressed in Escherichia coli

1991 • 73 citations

Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.

1996 • 72 citations

Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage.

1997 • 71 citations

Development of human T lymphocytes and their thymus-dependency.

1990 • 70 citations

Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset.

1991 • 65 citations

Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene.

1995 • 50 citations

Delimitation of the proliferative stages in the human thymus indicates that cell expansion occurs before the expression of CD3 (T cell receptor).

1993 • 43 citations

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis.

1992 • 42 citations

Identification of a Late Stage of Small Noncycling pTα− Pre-T Cells as Immediate Precursors of T Cell Receptor α/β+ Thymocytes

1998 • 40 citations

CD27 induction on thymocytes.

1990 • 35 citations

Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.

1995 • 35 citations

CD34‐positive early human thymocytes: T cell receptor and cytokine receptor gene expression

1995 • 28 citations

Limited combinatorial repertoire of gamma delta T-cell receptors expressed by T-cell acute lymphoblastic leukemias.

1991 • 16 citations

PJA-BP expression and TCR delta deletion during human T cell differentiation.

1998 • 10 citations