Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry

The scanning model for translation: an update.

1989 • 3,525 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Internal ribosome entry site within hepatitis C virus RNA

1992 • 914 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

1978 • 436 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

New initiation factor activity required for globin mRNA translation.

1983 • 416 citations

[27] Extension inhibition analysis of translation initiation complexes

1988 • 410 citations

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1994 • 384 citations

Initiation of mammalian protein synthesis

1977 • 341 citations

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes

1996 • 341 citations

Initiation of mammalian protein synthesis

1977 • 337 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

1993 • 327 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

1994 • 274 citations

Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation

1992 • 229 citations

Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA.

1995 • 218 citations

Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding.

1992 • 215 citations

The ATP-dependent interaction of eukaryotic initiation factors with mRNA.

1987 • 209 citations

The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.

1996 • 207 citations

Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism.

1990 • 205 citations

Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs

1989 • 197 citations

Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein

1991 • 155 citations

Regulation of Translation by Poliovirus

1987 • 152 citations

Role of ATP in binding and migration of 40S ribosomal subunits

1980 • 149 citations

Specific Interaction of Glyceraldehyde 3-Phosphate Dehydrogenase with the 5′-Nontranslated RNA of Hepatitis A Virus

1996 • 147 citations

Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

1976 • 138 citations

The involvement of a spliceosome component in internal initiation of human rhinovirus RNA translation

1993 • 134 citations

The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.

1993 • 130 citations

The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region

1994 • 129 citations

Translation of encephalomyocarditis virus RNA: parameters influencing the selection of the internal initiation site.

1994 • 126 citations

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

1990 • 125 citations

RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B.

1991 • 109 citations

Differential stimulation of capped mRNA translation in vitro by cap binding protein

1980 • 107 citations

Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation

1996 • 105 citations

Cap-Dependent and Cap-Independent Translation by Internal Initiation of mRNAs in Cell Extracts Prepared from Saccharomyces cerevisiae

1994 • 102 citations

[8] Purification of protein synthesis initiation factors from rabbit reticulocytes

1979 • 96 citations

Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition.

1992 • 96 citations

Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation

1991 • 91 citations

Features in the 5′ non-coding sequences of rabbit α and β-globin mRNAs that affect translational efficiency

1994 • 91 citations

Specificity in Initiation of Protein Synthesis in a Fractionated Mammalian Cell-free System

1973 • 90 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

A cellular 57 kDa protein binds to two regions of the internal translation initiation site of foot‐and‐mouth disease virus

1990 • 67 citations

Eukaryotic initiation factors-4E and -4F stimulate 5' cap-dependent as well as internal initiation of protein synthesis.

1992 • 66 citations

[44] Specific aminoacylation of the methionine-apecific tRNA's of eukaryotes

1974 • 64 citations

Translational control by messenger RNA competition for eukaryotic initiation factor 2.

1982 • 64 citations

Translation of Encephalomyocarditis Virus RNA by Internal Ribosomal Entry

1995 • 61 citations

The human insulin-like growth factor II leader 1 contains an internal ribosomal entry site

1995 • 60 citations

Pyrimidine tract binding protein strongly stimulates in vitro encephalomyocarditis virus RNA translation at the level of preinitiation complex formation

1994 • 59 citations

RNA-protein interactions within the internal translation initiation region of encephalomyocarditis virus RNA

1991 • 55 citations

A complex RNA sequence detemines the internal initiation of encephalomyocarditis virus RNA translation

1991 • 53 citations

Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells

1982 • 50 citations

A factor that specifically binds to the 5'‐untranslated region of encephalomyocarditis virus RNA

1990 • 47 citations

Mutational analysis of the J-K stem-loop region of the encephalomyocarditis virus IRES

1995 • 44 citations

Initiation activity of EMC virus RNA, binding to initiation factor eIF-4B and shut-off of host cell protein synthesis

1978 • 37 citations

The 5′ untranslated region of encephalomyocarditis virus contains a sequence for very efficient binding of eukaryotic initiation factor eIF-2/2B

1991 • 31 citations

New structure associated with stomatal complex of the fern Polypodium vulgare

1977 • 16 citations

Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI

1993 • 13 citations

Partial N‐terminal amino acid sequences of polypeptides p14 and p12 of encephalomyocarditis virus are identical and correspond to the N‐terminus of the viral polyprotein

1984 • 4 citations

Deleted Work

1955 • 0 citations