Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients.

Presence of fetal DNA in maternal plasma and serum

1997 • 2,884 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Free DNA in the serum of cancer patients and the effect of therapy.

1977 • 1,708 citations

Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis

1998 • 1,629 citations

Nuclear Acids In Human Blood Plasma.

1948 • 1,106 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.

1966 • 825 citations

Large plasmid in Agrobacterium tumefaciens essential for crown gall-inducing ability

1974 • 736 citations

Neoplastic Characteristics of the DNA Found in the Plasma of Cancer Patients

1989 • 687 citations

Microsatellite alterations in plasma DNA of small cell lung cancer patients

1996 • 656 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients.

1999 • 507 citations

Soluble normal and mutated DNA sequences from single-copy genes in human blood.

1994 • 478 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

1983 • 398 citations

Point mutations of the N‐ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia

1994 • 392 citations

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone.

1990 • 367 citations

Cell-Free DNA in Human Blood Plasma

1998 • 366 citations

Isolation and characterization of DNA from the plasma of cancer patients

1987 • 352 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease

1996 • 290 citations

Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours

1995 • 258 citations

K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer

1997 • 250 citations

The Occurrence of Single-Stranded DNA in the Serum of Patients with Systemic Lupus Erythematosus and Other Diseases

1973 • 244 citations

Molecular detection of genetic alterations in the serum of colorectal cancer patients.

1998 • 240 citations

Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system.

1975 • 233 citations

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

1987 • 231 citations

RELEASE OF DNA IN CIRCULATING BLOOD AND INDUCTION OF ANTI-DNA ANTIBODIES AFTER INJECTION OF BACTERIAL LIPOPOLYSACCHARIDES

1974 • 182 citations

Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer

1997 • 172 citations

Free DNA in serum and plasma from normal adults.

1975 • 165 citations

Excretion of Deoxyribonucleic Acid by Lymphocytes Stimulated with Phytohemagglutinin or Antigen

1972 • 158 citations

Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma.

1998 • 136 citations

Detection of chromosome 3p alterations in serum DNA of non-small-cell lung cancer patients

1998 • 93 citations

Detection of tumour DNA in serum of colorectal cancer patients

1997 • 72 citations

Rearranged Ig Heavy Chain DNA Is Detectable in Cell-Free Blood Samples of Patients With B-Cell Neoplasia

1997 • 69 citations

Nucleic acids spontaneously released by living frog auricles

1972 • 66 citations

Radioimmunoassay for nanogram quantities of DNA

1975 • 64 citations

Plasma dna in systemic lupus erythematosus. Characterization of cloned base sequences

1989 • 59 citations

TP53 gene mutations in plasma DNA of cancer patients

1999 • 56 citations

[Plasma DNA level as a tumor marker in primary lung cancer].

1990 • 51 citations

Agrobacterium tumefaciens Ribonucleic Acid Synthesis in Tomato Cells and Crown Gall Induction

1971 • 51 citations

Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis

1992 • 43 citations

Bacterial Ribonucleic Acid in the Frog Brain after a Bacterial Peritoneal Infection

1972 • 41 citations

Natural Release of Nucleic Acids from Bacteria into Plant Cells

1970 • 38 citations

Identification of an intracellular precursor to DNA excreted by human lymphocytes.

1976 • 32 citations

Genetic markers: The key to early diagnosis and improved survival in pancreatic cancer?

1996 • 26 citations

Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma

1998 • 25 citations

Modifications transmitted to the offspring provoked by heterograft in Solanum melongena

1963 • 23 citations

Transcription of Spontaneously Released Bacterial Deoxyribonucleic Acid in Frog Auricles

1973 • 21 citations

Capping of DNA on phytohemagglutinin-stimulated human lymphoblasts.

1981 • 15 citations

Correlation between in vitro DNA Synthesis, DNA Strand Separation and in vivo Multiplication of Cancer Cells

1981 • 9 citations

Diagnosis and Therapeutic Relevance of Micrometastases

1998 • 5 citations